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Evidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosus

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dc.creatorSánchez E.spa
dc.creatorGómez L.M.spa
dc.creatorLopez-Nevot M.A.spa
dc.creatorGonzález-Gay M.A.spa
dc.creatorSabio J.M.spa
dc.creatorOrtego-Centeno N.spa
dc.creatorde Ramón E.spa
dc.creatorAnaya, Juan-Manuelspa
dc.creatorGonzález-Escribano M.F.spa
dc.creatorKoeleman B.P.spa
dc.creatorMartín J.spa
dc.date.accessioned2020-05-26T00:09:07Z
dc.date.available2020-05-26T00:09:07Z
dc.date.created2006spa
dc.description.abstractThe aim of this study was to evaluate the potential association of functional polymorphisms of macrophage migration inhibitory factor with systemic lupus erythematosus. Our study includes 711 systemic lupus erythematosus (SLE) patients and 755 healthy controls. We genotyped the migration inhibitory factor (MIF) -173G/C using a polymerase chain reaction (PCR) system with predeveloped TaqMan allelic discrimination assay and the MIF -794 CATTn microsatellite polymorphism using a PCR-fluorescent method. A statistically significant difference in the distribution of the MIF -173*C allele between SLE patients and controls (P=0.004, OR=1.34, 95% CI=1.05-1.27) was observed. In addition, the frequency of the MIF -173* C/C genotype was higher in SLE patient (P=0.002, OR 2.58, 95% CI 1.32-5.10). No differences in the distribution of CATTn were found. However, the haplotypes analyses showed that only the CATT7-MIF -173* C haplotype was associated with a higher susceptibility to SLE (P=0.001, OR 1.84, 95% CI 1.35-2.79). No association with clinical features was detected in any case. These results suggest that both, MIF -173*C allele and CATT7-MIF -173*C haplotype, confer susceptibility to SLE in our population. © 2006 Nature Publishing Group. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1038/sj.gene.6364310
dc.identifier.issn14664879
dc.identifier.issn14765470
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24139
dc.language.isoengspa
dc.relation.citationEndPage436
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage433
dc.relation.citationTitleGenes and Immunity
dc.relation.citationVolumeVol. 7
dc.relation.ispartofGenes and Immunity, ISSN:14664879, 14765470, Vol.7, No.5 (2006); pp. 433-436spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33746350755&doi=10.1038%2fsj.gene.6364310&partnerID=40&md5=7dee25f208ddc56039c6d023768175edspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMacrophage migration inhibition factorspa
dc.subject.keywordhumaneng
dc.subject.keywordgeneticeng
dc.subject.keywordsingle nucleotideeng
dc.subject.keywordsystemiceng
dc.subject.keywordAdultspa
dc.subject.keywordpair 22eng
dc.subject.keywordAllelespa
dc.subject.keywordArticlespa
dc.subject.keywordClinical featurespa
dc.subject.keywordControlled studyspa
dc.subject.keywordGenetic associationspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenetic susceptibilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHaplotypespa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordPolymerase chain reactionspa
dc.subject.keywordPriority journalspa
dc.subject.keywordStatistical significancespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordAdultspa
dc.subject.keywordAllelesspa
dc.subject.keywordCase-control studiesspa
dc.subject.keywordChromosome mappingspa
dc.subject.keywordChromosomeseng
dc.subject.keywordConfidence intervalsspa
dc.subject.keywordEuropean continental ancestry groupspa
dc.subject.keywordFemalespa
dc.subject.keywordGene frequencyspa
dc.subject.keywordHaplotypesspa
dc.subject.keywordHumansspa
dc.subject.keywordLupus erythematosuseng
dc.subject.keywordMacrophage migration-inhibitory factorsspa
dc.subject.keywordMalespa
dc.subject.keywordMicrosatellite repeatsspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordOdds ratiospa
dc.subject.keywordPolymorphismeng
dc.subject.keywordPolymorphismeng
dc.subject.keywordPromoter regions (genetics)spa
dc.titleEvidence of association of macrophage migration inhibitory factor gene polymorphisms with systemic lupus erythematosusspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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