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Alterations in glucose metabolism on cognition: A possible link between diabetes and dementia

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dc.creatorGonzález Reyes, Rodrigo Estebanspa
dc.creatorAliev, Gjumrakchspa
dc.creatorAvila-Rodrigues, Marcospa
dc.creatorBarreto, George E.spa
dc.date.accessioned2020-08-19T14:40:01Z
dc.date.available2020-08-19T14:40:01Z
dc.date.created2016-02-01spa
dc.description.abstractThe use of the carbohydrate glucose as an energetic source is essential for an adequate function of the human body. The complex regulation of this molecule involves the coordinated action of various organs such as pancreas, liver and brain. Any disruption of this physiological balance may result in a dangerous compromise of general metabolic activities increasing the possibility of developing T1DM, T2DM and possibly AD. Astrocytes convert glucose into lactate and transfer it to neurons. This lactate is essential for neuronal metabolism and for various processes including the formation of synapses, dendrites and the expression of genes involved in memory. The brain is highly susceptible to variations in glucose blood levels, and both hypoglycemia and hyperglycemia can be dangerous. Pathological hyperglycemia induces changes in plasmatic osmotic pressure, mitochondrial production of free radicals, oxidative stress and activation of neuronal apoptosis, among others. Both AD and diabetes are chronic diseases having age as an important risk factor. As the brain ages, it seems to become much more susceptible to cellular damage induced by excess of circulating glucose and this could explain the appearance of cognitive changes observed in some patients with diabetes. Excessive circulation of pro-inflammatory agents has been observed in insulin resistance and is likely that some of these mediators may cross the bloodbrain barrier and induce abnormal neuroinflammation. GSK-3 is overexpressed in diabetes and also has been reported to regulate tau phosphorylation and production of A? peptides in the brain. Currently, diabetes (hyperglycemia) is considered as a risk factor for the development of AD. A novel therapeutic approach, using intranasal insulin and anti-diabetic medications in patients suffering from AD is being explored and is discussed in this review.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.2174/1381612822666151209152013
dc.identifier.issnISSN: 1381-6128
dc.identifier.issnEISSN: 1873-4286
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26673
dc.language.isoengspa
dc.publisherBentham Sciencespa
dc.relation.citationEndPage818
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage812
dc.relation.citationTitleCurrent Pharmaceutical Design
dc.relation.citationVolumeVol. 22
dc.relation.ispartofCurrent Pharmaceutical Design, ISSN:1381-6128;EISSN:1873-4286, Vol.22, No.7 (2016); pp. 812 - 818spa
dc.relation.urihttps://benthamscience.com/journals/current-pharmaceutical-design/volume/22/issue/7/page/812/spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceCurrent Pharmaceutical Designspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordDiabetesspa
dc.subject.keywordAlzheimer Diseasespa
dc.subject.keywordDementiaspa
dc.subject.keywordInsulin resistancespa
dc.subject.keywordAntidiabetic drugsspa
dc.titleAlterations in glucose metabolism on cognition: A possible link between diabetes and dementiaspa
dc.title.TranslatedTitleAlteraciones en el metabolismo de la glucosa en la cognición: un posible vínculo entre la diabetes y la demenciaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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