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The dual role of senescence in Tumorigenesis

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dc.creatorChuaire-Noack, Lilian
dc.creatorSanchez-Corredor, Magda-Carolina
dc.creatorRamírez Clavijo, Sandra Rocío
dc.creator.googleChuaire-Noack, Lilianspa
dc.creator.googleSánchez-Corredor, Magda Carolinaspa
dc.creator.googleRamírez-Clavijo, Sandra Rociospa
dc.date.accessioned2020-05-07T17:51:25Z
dc.date.available2020-05-07T17:51:25Z
dc.date.created2010
dc.date.issued2010
dc.description.abstractSenescence was rendered a tumor suppressor mechanism based on the observation of its protective effect against cancer in young organisms under conditions of oncogene activation or inactivation of tumor suppressor genes. In addition to this beneficial effect, senescence has been deemed to have age-associated deleterious effects because, apparently, senescence not only recapitulates aging and therefore loss of function and tissue regeneration capacity, but can also induce preneoplastic changes in adjacent stromal cells, provoke degenerative diseases or induce the production of tumor cell growth promoting factors. For that reason, senescence has become an attractive therapeutic target against cancer. This paper reviews some of the latest findings on the role of senescence in the malignant progression and analyzes them in relation to the concept of antagonistic pleiotropism, as well as its possible use as a therapeutic target against cancer.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4067/S0717-95022010000100006
dc.identifier.issn0717-9367
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21898
dc.language.isoengspa
dc.relation.citationEndPage50
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage37
dc.relation.citationTitleInternational Journal of Morphology
dc.relation.citationVolumeVol. 28
dc.relation.ispartofInternational Journal of Morphology, ISSN: 0717-9367 Vol. 28, No. 1 (2010) pp. 37-50spa
dc.relation.urihttps://scielo.conicyt.cl/pdf/ijmorphol/v28n1/art06.pdfspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcEnfermedadesspa
dc.subject.keywordSenescencespa
dc.subject.keywordCancerspa
dc.subject.keywordAntagonistic pleiotropismspa
dc.titleThe dual role of senescence in Tumorigenesisspa
dc.title.TranslatedTitlePapel dual de la senescencia en la tumorigénesisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículo de revisión spa
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