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Epstein-Barr virus and cytomegalovirus in autoimmune diseases are they truly notorious? A preliminary report

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dc.creatorAnaya, Juan-Manuelspa
dc.creatorRam, M.spa
dc.creatorSherer, Y.spa
dc.creatorShoenfeld, Y.spa
dc.date.accessioned2020-08-19T14:43:13Z
dc.date.available2020-08-19T14:43:13Z
dc.date.created2007spa
dc.description.abstractTo date, it is believed that the origin of autoimmune diseases is one of a multifactorial background. A genetic predisposition, an immune system malfunction or even backfire, hormonal regulation, and environmental factors all play important roles in the pathogenesis of autoimmune diseases. Among these environmental factors, the role of infection is known to be a major one. Epstein–Barr virus (EBV) and cytomegalovirus (CMV) are considered to be notorious as they are consistently associated with multiple autoimmune diseases. A cohort of 1595 serum samples, of 23 different autoimmune disease groups, was screened for evidence of prior infection with EBV and CMV. All samples were screened for antibodies against EBV nuclear antigen?1 (IgG), EBV viral capsid antigen (IgG and IgM), EBV early antigen (IgG), EBV heterophile antibody, and CMV (IgG and IgM) antibodies using Bio?Rad's BioPlex 2200. A new association is proposed between EBV and polymyositis, as results show a significant increase in titers of various EBV target analytes when compared with healthy controls. Our results also support prior information suggesting the association between EBV and multiple autoimmune diseases, including SLE, antiphospholipid syndrome, rheumatoid arthritis, multiple sclerosis, pemphigus vulgaris, giant cell arthritis, Wegener's granulomatosis, and polyarteritis nodosa (PAN). Elevated CMV IgG titers were observed in sera of SLE patients. Our data support the theory that EBV is notoriously associated with many autoimmune diseases. CMV appears to be associated to autoimmune diseases as well, yet establishing this theory requires further investigation.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1196/annals.1422.059
dc.identifier.issnISSN: 0077-8923
dc.identifier.issnEISSN: 1749-6632
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27663
dc.language.isoengspa
dc.publisherThe New York Academy of Sciencesspa
dc.relation.citationEndPage577
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage567
dc.relation.citationTitleAnnals of the New York Academy of Sciences
dc.relation.citationVolumeVol. 1108
dc.relation.ispartofAnnals of the New York Academy of Sciences, ISSN: 0077-8923 ;EISSN: 1749-6632 , Vol.1108 , No.1 ( June 2007); pp. 567-577spa
dc.relation.urihttps://nyaspubs.onlinelibrary.wiley.com/doi/epdf/10.1196/annals.1422.059spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceAnnals of the New York Academy of Sciencesspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordGenetic predispositionspa
dc.subject.keywordPathogenesisspa
dc.titleEpstein-Barr virus and cytomegalovirus in autoimmune diseases are they truly notorious? A preliminary reportspa
dc.title.TranslatedTitleEl virus de Epstein-Barr y el citomegalovirus en las enfermedades autoinmunes, ¿son realmente notorios? Un informe preliminarspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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