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Multiple sclerosis: Association to HLA DQ? in a tropical population

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dc.creatorArcos-Burgos, M.spa
dc.creatorPalacio, Gspa
dc.creatorSánchez, J.Lspa
dc.creatorLondoño, A.C.spa
dc.creatorUribe, C.S.spa
dc.date.accessioned2020-08-19T14:39:54Z
dc.date.available2020-08-19T14:39:54Z
dc.date.created1999-06spa
dc.description.abstractStudies performed in subtropical populations have found significant association between the phenotype multiple sclerosis (MS) and the major histocompatibility complex (MHC). We present the results of a case-control study conducted on a tropical population (Antioquia, Colombia) in order to detect a possible association between MS and HLA DQ? (HLA DQA1*) alleles. Forty chromosomes belonging to MS patients were compared to two sets of controls (40 and 910 chromosomes, respectively). The HLA DQA1*0101 and DQA1*0102 alleles were found in a significantly higher proportion among the cases than among the controls, whereas the HLA DQA1*0103 allele was found in a significantly lower proportion of the cases. These results suggest that the association of HLA DQA1*0101, DQA1*0102 and DQA1*0103 to the MS phenotype found in Caucasian subtropical populations remains in individuals with MS inhabiting the tropics. This finding could mean that the major genetic component associated to the MHC in subtropical populations is the same in the tropics.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1159/000019105
dc.identifier.issnISSN: 0254-9670
dc.identifier.issnEISSN: 1421-9948
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26619
dc.language.isoengspa
dc.publisherKarger AGspa
dc.relation.citationEndPage138
dc.relation.citationIssueNo. 3
dc.relation.citationStartPage131
dc.relation.citationTitleExperimental and Clinical Immunogenetics
dc.relation.citationVolumeVol. 16
dc.relation.ispartofExperimental and Clinical Immunogenetics, ISSN: 0254-9670;EISSN: 1421-9948, Vol.16, No.3 (1999); pp. 131-138spa
dc.relation.urihttps://www.karger.com/Article/Abstract/19105spa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceExperimental and Clinical Immunogeneticsspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordMultiple sclerosis ethnologyspa
dc.subject.keywordLinkage disequilibriumspa
dc.subject.keywordHLA-DQ Antigens geneticspa
dc.titleMultiple sclerosis: Association to HLA DQ? in a tropical populationspa
dc.title.TranslatedTitleEsclerosis múltiple: asociación con HLA DQ? en una población tropicalspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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