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The DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patients

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dc.creatorCalderón Ospina, Carlos Alberto
dc.creatorBustamante?Rojas, Carlosspa
dc.date.accessioned2020-05-25T23:55:36Z
dc.date.available2020-05-25T23:55:36Z
dc.date.created2010spa
dc.description.abstractObjective The aim was to determine the prevalence of adverse drug reactions (ADRs) in hospitalized patients in a university hospital. Methods ADRs were identified by two evaluators, who reviewed the clinical histories of all patients admitted between 24 April and 24 May 2006. Patients with suspected ADRs were contacted. Three different investigators evaluated causality, the degree of preventability, and the mechanism producing the ADR. Causality was assessed using the scale proposed by the World Health Organization (WHO), and preventability was assessed using the modified Schumock and Thornton criteria. Key findings There were 32 ADRs in 104 hospitalized patients. Effects on the autonomic nervous system were the most common (13%) and the drugs most frequently implicated were systemic antimicrobial drugs (19%). Fifty-four per cent of the ADRs were classified as possible. Using the Dose, Time and Susceptibility (DoTS) classification, 77% of the ADRs were classified as being of collateral dose-responsiveness (i.e. they occurred within the range of therapeutic doses), and 65% were classified as intermediate reactions. The susceptibility factors associated most frequently with ADRs were comorbidities (i.e. the presence of diseases that were considered as risk factors to developing an ADR; 36%), age (26%) and exogenous factors (i.e. the presence of drug interactions that were involved in the occurrence of ADRs; 17%). Fifty per cent of the ADRs could have been prevented. Conclusions ADRs are very frequent in hospitalized patients and a significant proportion of them is preventable. The DoTS classification allowed complete evaluation of the types of ADR encountered. We are currently carrying out a much larger prospective study. © 2010 Royal Pharmaceutical Society of Great Britain.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/j.2042-7174.2010.00039.x
dc.identifier.issn9617671
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22143
dc.language.isoengspa
dc.relation.citationEndPage235
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage230
dc.relation.citationTitleInternational Journal of Pharmacy Practice
dc.relation.citationVolumeVol. 18
dc.relation.ispartofInternational Journal of Pharmacy Practice, ISSN:9617671, Vol.18, No.4 (2010); pp. 230-235spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-77954709557&doi=10.1111%2fj.2042-7174.2010.00039.x&partnerID=40&md5=c7068666e9b7d36ac839df7e6ce28b33spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAntiinfective agentspa
dc.subject.keywordAdultspa
dc.subject.keywordAdverse drug reactionspa
dc.subject.keywordAgedspa
dc.subject.keywordArticlespa
dc.subject.keywordAutonomic neuropathyspa
dc.subject.keywordComorbidityspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDisease classificationspa
dc.subject.keywordDisease predispositionspa
dc.subject.keywordDose time susceptibility classificationspa
dc.subject.keywordFemalespa
dc.subject.keywordHospital patientspa
dc.subject.keywordHumanspa
dc.subject.keywordMajor clinical studyspa
dc.subject.keywordMalespa
dc.subject.keywordPrevalencespa
dc.subject.keywordPriority journalspa
dc.subject.keywordRisk factorspa
dc.subject.keywordUniversity hospitalspa
dc.subject.keywordWorld health organizationspa
dc.subject.keywordAdverse drug reaction reporting systemsspa
dc.subject.keywordAge factorsspa
dc.subject.keywordAgedspa
dc.subject.keywordColombiaspa
dc.subject.keywordComorbidityspa
dc.subject.keywordCross-sectional studiesspa
dc.subject.keywordDose-response relationshipeng
dc.subject.keywordDrug interactionsspa
dc.subject.keywordFemalespa
dc.subject.keywordHospitalseng
dc.subject.keywordHumansspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPharmaceutical preparationsspa
dc.subject.keywordRisk factorsspa
dc.subject.keywordTime factorsspa
dc.subject.keywordAdverse effectsspa
dc.subject.keywordDrug utilizationspa
dc.subject.keywordHospitalizationspa
dc.subject.keywordInternal medicinespa
dc.subject.keywordPharmacoepidemiologyspa
dc.subject.keywordPostmarketingspa
dc.subject.keywordProduct surveillancespa
dc.titleThe DoTS classification is a useful way to classify adverse drug reactions: A preliminary study in hospitalized patientsspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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