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Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis

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dc.audienceComunidad Rosaristaspa
dc.creatorBarragán Martínez, Carolina
dc.creatorSpeck Hernández, Cesar A.
dc.creatorMontoya-Ortiz, Gladis
dc.creatorMantilla, Rubén D.
dc.creatorAnaya, Juan-Manuel
dc.creatorRojas-Villarraga, Adriana
dc.creator.googleBarragán Martínez, Carolina
dc.creator.googleSpeck Hernández, Cesar A.
dc.creator.googleMontoya-Ortiz, Gladis
dc.creator.googleMantilla, Rubén D.
dc.creator.googleAnaya, Juan-Manuel
dc.creator.googleRojas-Villarraga, Adriana
dc.date.accessioned2014-08-13T16:19:59Z
dc.date.available2014-08-13T16:19:59Z
dc.date.created2012
dc.date.issued2012-12-19
dc.description.abstractBackground: Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs. Methods and Findings: The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value, 0.001). Conclusion: Exposure to OSs is a risk factor for developing ADs. As a corollary, individuals with non-modifiable risk factors (i.e., familial autoimmunity or carrying genetic factors) should avoid any exposure to OSs in order to avoid increasing their risk of ADs.eng
dc.format.mediumRecurso electrónicospa
dc.format.mimetypeapplication/pdf
dc.format.tipoDocumentospa
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0051506
dc.identifier.issn1932-6203
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/8830
dc.language.isoeng
dc.publisherUniversidad del Rosariospa
dc.relation.citationIssueNo. 12
dc.relation.citationTitlePLOS ONE
dc.relation.citationVolumeVol. 7
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 7 N. 12 Dic, 2012spa
dc.relation.urihttp://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjournal.pone.0051506&representation=PDF
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto completo)spa
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subjectCirrosis biliar primariaspa
dc.subjectAductos de proteína de aldehídospa
dc.subjectActivación de células Tspa
dc.subjectAutoinmunidad mediadaspa
dc.subjectTricloroetenospa
dc.subjectExposición al cloruro de vinilospa
dc.subjectEsclerosis múltiplespa
dc.subjectExposicion ocupacionalspa
dc.subjectLupus eritematosospa
dc.subjectFactores medioambientalesspa
dc.subjectEnfermeras anestesistasspa
dc.subject.ddcEvolución & genética
dc.subject.decsGenéticaspa
dc.subject.decsRepresión epigenéticaspa
dc.subject.decsEnfermedades autoinmunesspa
dc.subject.keywordPrimary biliary cirrhosiseng
dc.subject.keywordAldehyde-protein adductseng
dc.subject.keywordT-cell-activationeng
dc.subject.keywordTrichloroethene-mediated autoimmunityeng
dc.subject.keywordVinyl-chloride exposureeng
dc.subject.keywordMultiple-sclerosiseng
dc.subject.keywordOccupational-exposureeng
dc.subject.keywordLupus-erythematosuseng
dc.subject.keywordEnvironmental-factorseng
dc.subject.keywordNurse anesthetistseng
dc.titleOrganic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
dc.type.spaArtículospa
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