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Functional, biochemical and 3D studies of Mycobacterium tuberculosis protein peptides for an effective anti-tuberculosis vaccine

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dc.creatorOcampo, Marisol
dc.creatorPatarroyo, Manuel A.spa
dc.creatorVanegas, Magnoliaspa
dc.creatorAlba, Martha P.spa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-05-26T00:05:21Z
dc.date.available2020-05-26T00:05:21Z
dc.date.created2014spa
dc.description.abstractTuberculosis (TB) is an air-born, transmissible disease, having an estimated 9.4 million new TB cases worldwide in 2009. Eventual control of this disease by developing a safe and efficient new vaccine able to detain its spread will have an enormous impact on public health policy. Selecting potential antigens to be included in a multi-epitope, minimal subunit-based, chemically-synthesized vaccine containing the minimum sequences needed for blocking mycobacterial interaction with host cells is a complex task due to the multiple mechanisms involved in M. tuberculosis infection and the mycobacterium's immune evasion mechanisms. Our methodology, described here takes into account a highly robust, specific, sensitive and functional approach to the search for potential epitopes to be included in an anti-TB vaccine; it has been based on identifying short mycobacterial protein fragments using synthetic peptides having high affinity interaction with alveolar epithelial cells (A549) and monocyte-derived macrophages (U937) which are able to block the microorganism's entry to target cells in in vitro assays. This manuscript presents a review of the results obtained with some of the MTB H37Rv proteins studied to date, aimed at using these high activity binding peptides (HABPs) as platforms to be included in a minimal subunit-based, multiepitope, chemically-synthesized, antituberculosis vaccine. © 2014 Informa Healthcare USA, Inc. All rights reserved: reproduction in whole or part not permitted.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.3109/1040841X.2013.763221
dc.identifier.issn15497828
dc.identifier.issn1040841X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23782
dc.language.isoengspa
dc.relation.citationEndPage145
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage117
dc.relation.citationTitleCritical Reviews in Microbiology
dc.relation.citationVolumeVol. 40
dc.relation.ispartofCritical Reviews in Microbiology, ISSN:15497828, 1040841X, Vol.40, No.2 (2014); pp. 117-145spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84891085960&doi=10.3109%2f1040841X.2013.763221&partnerID=40&md5=ed6960a662a4b4df4c6560ddc2487e93spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordBacterial antigenspa
dc.subject.keywordBacterial proteinspa
dc.subject.keywordBcg vaccinespa
dc.subject.keywordRv 0180 c proteinspa
dc.subject.keywordRv 0227 c proteinspa
dc.subject.keywordRv 0679 c proteinspa
dc.subject.keywordRv 1490 proteinspa
dc.subject.keywordRv 1510 c proteinspa
dc.subject.keywordRv 1980 c proteinspa
dc.subject.keywordRv 2004 c proteinspa
dc.subject.keywordRv 2301 proteinspa
dc.subject.keywordRv 2536 proteinspa
dc.subject.keywordRv 2560 proteinspa
dc.subject.keywordRv 2707 proteinspa
dc.subject.keywordRv 2969c proteinspa
dc.subject.keywordRv 3166 c proteinspa
dc.subject.keywordRv 3481 c proteinspa
dc.subject.keywordRv 3629 c proteinspa
dc.subject.keywordRv 3630 proteinspa
dc.subject.keywordRv 3804 c proteinspa
dc.subject.keywordRv 3910 proteinspa
dc.subject.keywordSynthetic peptidespa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordBioinformaticsspa
dc.subject.keywordImmune responsespa
dc.subject.keywordMolecular biologyspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein analysisspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtein functionspa
dc.subject.keywordProteomicsspa
dc.subject.keywordReviewspa
dc.subject.keywordThree dimensional imagingspa
dc.subject.keywordAntigenseng
dc.subject.keywordBacterial adhesionspa
dc.subject.keywordBacterial proteinsspa
dc.subject.keywordCell linespa
dc.subject.keywordEpithelial cellsspa
dc.subject.keywordHumansspa
dc.subject.keywordMacrophagesspa
dc.subject.keywordMycobacterium tuberculosisspa
dc.subject.keywordTuberculosis vaccinesspa
dc.subject.keywordMycobacterium tuberculosis surface proteinspa
dc.subject.keywordReceptor-ligand interactionspa
dc.subject.keywordSubunit-vaccinespa
dc.subject.keywordSynthetic-peptidesspa
dc.titleFunctional, biochemical and 3D studies of Mycobacterium tuberculosis protein peptides for an effective anti-tuberculosis vaccinespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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