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Serotyping of toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South America

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dc.creatorMorisseta, Stéphanespa
dc.creatorPeyron, Françoisspa
dc.creatorLobry, Jean R.spa
dc.creatorGarweg, Justusspa
dc.creatorFerrandiz, Josettespa
dc.creatorMussethi, Karinespa
dc.creatorGomez-Marine, Jorge Enriquespa
dc.creatorde-la-Torre, Alejandraspa
dc.creatorDemar, Magalispa
dc.creatorCarme, Bernardspa
dc.creatorMercier, Corinnespa
dc.creatorGarin, Jean Françoisspa
dc.creatorCesbron-Delauw, Marie-Francespa
dc.date.accessioned2020-08-19T14:40:34Z
dc.date.available2020-08-19T14:40:34Z
dc.date.created2008-06spa
dc.description.abstractField isolates of Toxoplasma gondii in Europe and North America have been grouped into three clonal lineages that display different virulence in mice. Whether the genetic structure of the parasite is related to clinical expression in humans has not yet been demonstrated. We developed an enzyme-linked immunosorbent assay which uses lineage-specific, polymorphic polypeptides derived from the dense granule antigens, GRA5 and GRA6. Our goal was to compare serotypical patterns observed in asymptomatic versus symptomatic (ocular disease and severe infection in human immunodeficiency virus (HIV)-positive patients) infections among patients from Europe and South America. Independent of the clinical presentation of the disease, serotypes differed according to geographical origin, with a homogeneous distribution of serotype II in Europe and of serotypes I and III in South America. We conclude that GRA5–GRA6 serotyping is an interesting tool to study serotype prevalence in populations but it is not an accurate marker of pathogenicity of Toxoplasma infection in humans.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.micinf.2008.04.001
dc.identifier.issnISSN: 1286-4579
dc.identifier.issnEISSN: 1769-714X
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26937
dc.language.isoengspa
dc.publisherInstitut Pasteurspa
dc.publisherElsevierspa
dc.relation.citationEndPage747
dc.relation.citationIssueNo. 7
dc.relation.citationStartPage742
dc.relation.citationTitleMicrobes and Infection
dc.relation.citationVolumeVol. 10
dc.relation.ispartofMicrobes and Infection, ISSN: 1286-4579;EISSN: 1769-714X, Vol.10, No.7 (2008); pp. 742-747spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S1286457908000920?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceMicrobes and Infectionspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordToxoplasma gondii isolatesspa
dc.subject.keywordSerotypingspa
dc.subject.keywordType Ispa
dc.subject.keywordIIspa
dc.subject.keywordIIIspa
dc.subject.keywordGRA5spa
dc.subject.keywordGRA6spa
dc.titleSerotyping of toxoplasma gondii: striking homogeneous pattern between symptomatic and asymptomatic infections within Europe and South Americaspa
dc.title.TranslatedTitleSerotipificación de toxoplasma gondii: sorprendente patrón homogéneo entre infecciones sintomáticas y asintomáticas en Europa y América del Surspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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