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Meta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritis

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dc.creatorDelgado-Vega, Angélica M.spa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-26T00:01:13Z
dc.date.available2020-05-26T00:01:13Z
dc.date.created2007spa
dc.description.abstractObjectives: To estimate the common effect size of HLA-DRB1 alleles on rheumatoid arthritis (RA) susceptibility across Latin America populations through a meta-analysis combining the results of published data. Methods: Case-control studies on HLA-DRB1 association with RA in Latin America were searched up to October 2006. Genotype frequencies were extracted according to both shared epitope (SE) and HLA-DR4 positive or negative alleles. The effect summary odds ratio (OR) and 95% confidence intervals was obtained. Heterogeneity and publication bias were assessed. Results: Eight studies containing 684 cases and 1015 controls were included. Under the random effects model, the common OR was 3.28 (1.93, 5.60) (p and lt; 0.0001) and 3.54 (2.47, 5.05) (p = 4.22 × 10- 12) for HLA-DR4 and SE, respectively. There was no evidence of publication bias according to Funnel plot and Egger's regression test (p = 0,445 for DR4 and p = 0,464 for SE meta-analysis). Significant heterogeneity was observed for HLA-DR4 (I2 = 81.06%, Q = 36.96, p = 0.000005) but not for the SE meta-analysis. Conclusions: HLA-DR4 and SE positive HLA-DRB1 alleles (mainly HLA-DRB1*0404) are associated with RA in Latin Americans. Heterogeneity is expected owing to the diverse degree of admixture between the examined populations. Our findings support the HLA as a major susceptibility locus for RA and validate the SE hypothesis in Latin America. © 2007 Elsevier B.V. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2006.11.004
dc.identifier.issn15689972
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23333
dc.language.isoengspa
dc.relation.citationEndPage408
dc.relation.citationIssueNo. 6
dc.relation.citationStartPage402
dc.relation.citationTitleAutoimmunity Reviews
dc.relation.citationVolumeVol. 6
dc.relation.ispartofAutoimmunity Reviews, ISSN:15689972, Vol.6, No.6 (2007); pp. 402-408spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-34249300159&doi=10.1016%2fj.autrev.2006.11.004&partnerID=40&md5=cd68e82b6518d9ac64ff9252665fd0adspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordEpitopespa
dc.subject.keywordmhc class iieng
dc.subject.keywordrheumatoideng
dc.subject.keywordHla dr4 antigenspa
dc.subject.keywordgeneticeng
dc.subject.keywordAllelespa
dc.subject.keywordConfidence intervalspa
dc.subject.keywordEpitope mappingspa
dc.subject.keywordGenetic heterogeneityspa
dc.subject.keywordGenetic polymorphismspa
dc.subject.keywordGenotypespa
dc.subject.keywordHla systemspa
dc.subject.keywordHumanspa
dc.subject.keywordInformation processingspa
dc.subject.keywordMolecular phylogenyspa
dc.subject.keywordRegression analysisspa
dc.subject.keywordReviewspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSouth and central americaspa
dc.subject.keywordStatistical analysisspa
dc.subject.keywordAllelesspa
dc.subject.keywordArthritiseng
dc.subject.keywordCase-control studiesspa
dc.subject.keywordGeneseng
dc.subject.keywordGenetic predisposition to diseasespa
dc.subject.keywordGenotypespa
dc.subject.keywordHla-dr antigensspa
dc.subject.keywordHumansspa
dc.subject.keywordLatin americaspa
dc.subject.keywordPolymorphismeng
dc.subject.keywordRegression analysisspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordHla antigensspa
dc.subject.keywordLatin americaspa
dc.subject.keywordMajor histocompatibility complexspa
dc.subject.keywordMeta-analysisspa
dc.subject.keywordRheumatoid arthritisspa
dc.titleMeta-analysis of HLA-DRB1 polymorphism in Latin American patients with rheumatoid arthritisspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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