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Defects in the synthesis of ζ chain in T lymphocytes, generating wrong intracellular signals, responsible for systemic lupus erythematosus

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dc.creatorM., Heber Siachoquespa
dc.creatorRondón, Federicospa
dc.creatorRestrepo, José Félixspa
dc.creatorPérez, Ruthspa
dc.creatorIglesias, Antoniospa
dc.date.accessioned2020-05-25T23:59:34Z
dc.date.available2020-05-25T23:59:34Z
dc.date.created2010spa
dc.description.abstractThe abnormal expression of key molecules in signaling and the malfunction of the T cell T have a significant activity in the pathogenesis of the autoimmune disease. The cells T exhibit numerous abnormalities in the signaling of the complex TCR1, these aberrations result in the alteration of the citoquines. While some of these abnormalities explain the increase of the activity of cells B for cells T with increment of the antibodies production, the decrease in the production of IL-2 induces an increase in the susceptibility to the infections, diminishing in the activation of the cells T, and expansion of the lifespan of the autorreactive cells2. © 2010 Asociación Colombiana de Reumatologíaspa
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/S0121-8123(10)70069-4
dc.identifier.issn01218123
dc.identifier.issn20279000
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23068
dc.language.isospaspa
dc.publisherAsociacion Colombiana de Reumatologíaspa
dc.relation.citationEndPage230
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage219
dc.relation.citationTitleRevista Colombiana de Reumatología
dc.relation.citationVolumeVol. 17
dc.relation.ispartofRevista Colombiana de Reumatología, ISSN:01218123, 20279000, Vol.17, No.4 (2010); pp. 219-230spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85009428044&doi=10.1016%2fS0121-8123%2810%2970069-4&partnerID=40&md5=3e0f69c2e8284066d617b46830464ec4spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordInterleukin 2spa
dc.subject.keywordT lymphocyte receptorspa
dc.subject.keywordT lymphocyte receptor zeta chainspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAntibody productionspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordCell expansionspa
dc.subject.keywordCytokine productionspa
dc.subject.keywordInfection sensitivityspa
dc.subject.keywordIntracellular signalingspa
dc.subject.keywordPathogenesisspa
dc.subject.keywordProtein synthesisspa
dc.subject.keywordReviewspa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordT lymphocytespa
dc.subject.keywordT lymphocyte activationspa
dc.subject.keywordCamkivspa
dc.subject.keywordCtla-4spa
dc.subject.keywordElf-1spa
dc.subject.keywordFcγspa
dc.subject.keywordItamspa
dc.subject.keywordLesspa
dc.subject.keywordLupusspa
dc.subject.keywordTcrζspa
dc.subject.keywordUtrspa
dc.titleDefects in the synthesis of ζ chain in T lymphocytes, generating wrong intracellular signals, responsible for systemic lupus erythematosusspa
dc.title.TranslatedTitleDefectos en la síntesis de cadena ζ en el linfocito T, generando señales intracelulares equivocadas, responsables de lupus eritematoso sistémicospa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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