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Leptin : Role over central nervous system in epilepsy

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dc.creatorMora‑Muñoz, Laura
dc.creatorGuerrero‑Naranjo, Alejandro
dc.creatorRodríguez‑Jimenez, Elisa Angélica
dc.creatorMastronardi, Claudio
dc.creatorVélez van Meerbeke, Alberto Francisco
dc.creator.googleMora‑Muñoz, Lauraspa
dc.creator.googleGuerrero‑Naranjo, Alejandrospa
dc.creator.googleRodríguez‑Jimenez, Elisa Angélicaspa
dc.creator.googleMastronardi, Claudio Albertospa
dc.creator.googleVelez- van-Meerbeke, Albertospa
dc.date.accessioned2019-02-12T20:14:25Z
dc.date.available2019-02-12T20:14:25Z
dc.date.created2018
dc.date.issued2018
dc.description.abstractAdipose tissue is a dynamic organ with different effects on the body. Many of these effects are mediated by leptin, a hormone strongly involved in regulation of feeding and energy metabolism. It has an important role as a mediator of neuronal excitatory activity and higher brain functions. The aim of this study was to review the association between leptin and cerebral neuronal function, in particular its anticonvulsant or convulsant effects and the possible therapeutic role for treating epilepsy. For this purpose, the databases Pubmed, Science Direct, Elsevier, ResearchGate and Scielo were searched to identify experimental studies, reviews and systematic review articles, published in English, Spanish or Portuguese. Experimental studies and the presence of leptin receptors in nervous system sites other than the hypothalamus suggest an influence on higher brain functions. Indeed several animal studies have demonstrated a role of these channels in epileptiform activity as both anticonvulsive and convulsive effects have been found. The reason for these discrepancies is unclear but provides clear evidence of a potential role of leptin and leptin therapy in epileptiform activity. The association between leptin and brain function demonstrates the importance of peripheral metabolic hormones on central nervous system and opens a new way for the development of novel therapeutic interventions in diseases like epilepsy. Nevertheless further investigations are important to clarify the dynamics and diverse actions of leptin on excitatory regulation in the brain. © 2018 The Author(s).eng
dc.format.mimetypeapplication/pdf
dc.identifier.doi10.1186/s12868-018-0453-9
dc.identifier.issn1471-2202
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/19051
dc.language.isoengspa
dc.relation.citationTitleBMC Neuroscience
dc.relation.citationVolumeVol. 19
dc.relation.ispartofBMC Neuroscience, ISSN:1471-2202, Vol. 19 (2018)spa
dc.relation.urihttps://bmcneurosci.biomedcentral.com/track/pdf/10.1186/s12868-018-0453-9spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.bibliographicCitationDoherty, G.H., Obesity and the ageing brain: could leptin play a role in neurodegeneration? (2011) Curr Gerontol Geriatr Res, 2011, p. 8spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subjectLeptinspa
dc.subjectLeptin Receptorspa
dc.subjectAnticonvulsant Activityspa
dc.subjectBrain Functionspa
dc.subjectCentral Nervous Systemspa
dc.subjectData Basespa
dc.subjectDisease Associationspa
dc.subjectDrug Effectspa
dc.subjectDrug Efficacyspa
dc.subjectDrug Mechanismspa
dc.subjectDrug Responsespa
dc.subjectEpilepsyspa
dc.subjectHumanspa
dc.subjectHypothalamusspa
dc.subjectNonhumanspa
dc.subjectProtein Expressionspa
dc.subjectReviewspa
dc.subjectSignal Transductionspa
dc.subjectTreatment Outcomespa
dc.subject.ddcAnatomía humana, citología, histologíaspa
dc.subject.lembLeptinaspa
dc.subject.lembReceptor de leptinaspa
dc.subject.lembActividad anticonvulsivaspa
dc.subject.lembFunción del cerebrospa
dc.subject.lembCircuito neuronalspa
dc.titleLeptin : Role over central nervous system in epilepsyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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