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Protective immunity provided by a new modified SERA protein peptide: Its immunogenetic characteristics and correlation with 3D structure

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dc.creatorBermudez, Adriana
dc.creatorMoreno-Vranich, Armandospa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-05-26T00:10:43Z
dc.date.available2020-05-26T00:10:43Z
dc.date.created2012spa
dc.description.abstractThe serine repeat antigen (SERA) protein is a leading candidate molecule for inclusion as a component in a multi-antigen, multi-stage, minimal subunit-based, chemically synthesised anti-malarial vaccine. Peptides having high red blood cell binding affinity (known as HABPs) have been identified in this protein. The 6733 HABP was located in the C-terminal portion of the 47-kDa fragment while HABP 6754 was located in the C-terminal region of the 56-kDa fragment. These conserved HABPs failed to induce an immune response. Critical red blood cell binding residues and/or their neighbours (assessed by glycine-analogue scanning) were replaced by others having the same mass, volume and surface but different polarity, rendering some of them highly immunogenic when assessed by antibody production against the parasite or its proteins and protection-inducers against experimental challenge with a highly infectious Aotus monkey-adapted Plasmodium falciparum strain. This manuscript presents some modified HABPs as vaccine candidate components for enriching our tailor-made anti-malarial vaccine repertoire, as well as their 3D structure obtained by 1H-NMR displaying a short-structured region, differently from the native ones having random structures. © 2011 Springer-Verlag.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1007/s00726-011-1061-5
dc.identifier.issn09394451
dc.identifier.issn14382199
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24252
dc.language.isoengspa
dc.relation.citationEndPage194
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage183
dc.relation.citationTitleAmino Acids
dc.relation.citationVolumeVol. 43
dc.relation.ispartofAmino Acids, ISSN:09394451, 14382199, Vol.43, No.1 (2012); pp. 183-194spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84862760079&doi=10.1007%2fs00726-011-1061-5&partnerID=40&md5=fa2e94b00796aed08f516b57bec9f69fspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordmoleculareng
dc.subject.keywordSerine repeat antigen protein derivativespa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAmino acid substitutionspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAntibody productionspa
dc.subject.keywordArticlespa
dc.subject.keywordBinding affinityspa
dc.subject.keywordCarboxy terminal sequencespa
dc.subject.keywordControlled studyspa
dc.subject.keywordErythrocytespa
dc.subject.keywordHaplorhinispa
dc.subject.keywordImmunityspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordMalaria falciparumspa
dc.subject.keywordMolecular modelspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein structurespa
dc.subject.keywordProton nuclear magnetic resonancespa
dc.subject.keywordThree dimensional imagingspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordAotidaespa
dc.subject.keywordErythrocytesspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMalariaeng
dc.subject.keywordModelseng
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordRepetitive sequenceseng
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordNmrspa
dc.subject.keywordSera 5spa
dc.subject.keywordStructurespa
dc.titleProtective immunity provided by a new modified SERA protein peptide: Its immunogenetic characteristics and correlation with 3D structurespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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