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Zinc and epilepsy: Is there a causal relation between them?

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dc.creatorMoreno C.B.spa
dc.creatorGutiérrez-Álvarez A.M.spa
dc.creatorGonzález Reyes, Rodrigo Estebanspa
dc.date.accessioned2020-05-25T23:59:55Z
dc.date.available2020-05-25T23:59:55Z
dc.date.created2006spa
dc.description.abstractIntroduction. Zinc is a fundamental trace element for an adequate nervous system function. It has been suggested that in the brain, a zinc homeostasis alteration may be associated with the genesis of epilepsy, although it is not yet determined if concentrations of zinc are a cause or a consequence of seizures. Another poorly studied aspect is the relationship between antiepileptic drugs and the neuronal zinc behaviour. Development. We perform a systematic review of the literature to evaluate the role that zinc plays in epilepsy as well as the antiepileptic effect of zinc concentrations. Databases such as MEDLINE, EMBASE, SCISEARCH and LILACS were consulted from January 1974 to July 2005. All articles published in English and Spanish were considered. A manual review of the references present in each article was done in order to identify the articles that the electronic search may have not found itself. The title and abstract of the potential articles were analyzed before asking for the complete article. However, articles that seemed ambiguous were completely analyzed later to establish their relevance. Conclusions. Clinical research in epilepsy presented contradictory results. In fact, the reviewed studies, both animal and human, did not give enough evidence to determine if organic zinc variations are directly related to epilepsy. Most of them gave not statistically significant results. © 2006, Revista de Neurología.eng
dc.format.mimetypeapplication/pdf
dc.identifier.issn2100010
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23130
dc.language.isoengspa
dc.relation.citationEndPage759
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage754
dc.relation.citationTitleRevista de Neurologia
dc.relation.citationVolumeVol. 42
dc.relation.ispartofRevista de Neurologia, ISSN:2100010, Vol.42, No.12 (2006); pp. 754-759spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33750126648&partnerID=40&md5=15ae8dbf2b5f6a19eaf587d6725ffd2dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keyword4 aminobutyric acidspa
dc.subject.keywordbibliographiceng
dc.subject.keywordValproic acidspa
dc.subject.keywordZincspa
dc.subject.keywordAnticonvulsive agentspa
dc.subject.keywordZincspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordHomeostasisspa
dc.subject.keywordHumanspa
dc.subject.keywordMedlinespa
dc.subject.keywordMonotherapyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordReviewspa
dc.subject.keywordScisearchspa
dc.subject.keywordSeizurespa
dc.subject.keywordSynaptic transmissionspa
dc.subject.keywordAnimalspa
dc.subject.keywordBibliographic databasespa
dc.subject.keywordLiteraturespa
dc.subject.keywordMetabolismspa
dc.subject.keywordPathophysiologyspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAnticonvulsantsspa
dc.subject.keywordDatabaseseng
dc.subject.keywordEpilepsyspa
dc.subject.keywordHomeostasisspa
dc.subject.keywordHumansspa
dc.subject.keywordReview literaturespa
dc.subject.keywordZincspa
dc.subject.keywordAcademic reviewspa
dc.subject.keywordAnticonvulsantsspa
dc.subject.keywordEpilepsyspa
dc.subject.keywordEvidence-based medicinespa
dc.subject.keywordTrace elementsspa
dc.subject.keywordZincspa
dc.titleZinc and epilepsy: Is there a causal relation between them?spa
dc.title.TranslatedTitleZinc y epilepsia: ¿Existe una relación causal?spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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