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Biofilm-Associated Candidiasis

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dc.creatorRosenau, Frankspa
dc.creatorFiracative Ropero, Sandra Carolinaspa
dc.creatorKissmann, Ann-Kathrinspa
dc.creatorAmann, Valeriespa
dc.date.accessioned2025-07-21T16:57:41Z
dc.date.available2025-07-21T16:57:41Z
dc.date.created2025-04-01spa
dc.date.issued2025-04-01spa
dc.description.abstractAbstract: The rising prevalence of fungal infections, especially those caused by Candida species, presents a major risk to global health. With approximately 1.5 million deaths annually, the urgency for effective treatment options has never been greater. Candida spp. are the leading cause of invasive infections, significantly impacting immunocompromised patients and those in healthcare settings. C. albicans, C. parapsilosis and the emerging species C. auris are categorized as highly dangerous species because of their pathogenic potential and increasing drug resistance. This review comparatively describes the formation of microbial biofilms of both bacterial and fungal origin, including major pathogens, thereby creating a novel focus. Biofilms can further complicate treatment, as these structures provide enhanced resistance to antifungal therapies. Traditional antifungal agents, including polyenes, azoles and echinocandins, have shown effectiveness, yet resistance development continues to rise, necessitating the exploration of novel therapeutic approaches. Antimicrobial peptides (AMPs) such as the anti-biofilm peptides Pom-1 and Cm-p5 originally isolated from snails represent promising candidates due to their unique mechanisms of action and neglectable cytotoxicity. This review article discusses the challenges posed by Candida infections, the characteristics of important species, the role of biofilms in virulence and the potential of new therapeutic options like AMPs.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.3390/ph18040460spa
dc.identifier.issn1424-8247spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46126
dc.language.isoengspa
dc.publisherMDPIspa
dc.relation.ispartofPharmaceuticals 2025, 18, 460spa
dc.relation.urihttps://www.mdpi.com/1424-8247/18/4/460spa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourcePharmaceuticalsspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordMedicina moleculareng
dc.subject.keywordCandidaeng
dc.subject.keywordCandidiasiseng
dc.subject.keywordC. albicanseng
dc.subject.keywordC. parapsilosiseng
dc.subject.keywordC. auriseng
dc.subject.keywordBiofilmeng
dc.subject.keywordResistanceeng
dc.subject.keywordFungicideseng
dc.subject.keywordAnti-biofilmeng
dc.subject.keywordAntimicrobial peptideseng
dc.titleBiofilm-Associated Candidiasisspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de revisiónspa
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