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Frequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitude

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dc.creatorGiraldo, Juan Cspa
dc.creatorAcosta, Claudiaspa
dc.creatorGiraldo-Grueso, Manuelspa
dc.date.accessioned2020-05-25T23:56:57Z
dc.date.available2020-05-25T23:56:57Z
dc.date.created2018spa
dc.description.abstractThis study reported the frequency of anesthetic overdose measured with the bispectral index in a high altitude city (Bogotá-Colombia, 2600 meters above sea level). We assembled a prospective cohort of patients. Preoperative variables were described, and 10 minutes after the surgical incision, bispectral index, mean alveolar concentration, mean arterial pressure, and oxygen saturation were recorded. Bispectral index was classified as superficial (60), adequate (40-60), and deep (> 40). Mean alveolar concentration was classified as low ( less than 0.8), normal (0.8-1.2), and high (> 1.2). We included 50 patients. The mean age of the patients was 36.3 ± 13.5 years; 48% were male and 78% were categorized as ASA I. Mean values of mean alveolar concentration and bispectral index were 1.14 ± 0.18 and 38.66 ± 6.9, respectively. Frequency of anesthetic overdose measured with bispectral index was 54% and only 20% with mean alveolar concentration. In total, 78% of patients received normal mean alveolar concentration values, and among these patients, 49% had deep bispectral index levels and 51% were adequate. There was no correlation between mean alveolar concentration and bispectral index (Pearson r = 0.161, P = 0.246) or between bispectral index and mean arterial pressure (Pearson r = 0.367, P = 0.08). All patients older than 60 years exhibited deep bispectral index levels, and although we did not identify a correlation between age and bispectral index, a tendency was observed (Pearson r = -0.087, P = 0.538). Safe and effective anesthesia overdose could be a common phenomenon. Bispectral index-guided anesthesia could be a helpful and reliable tool in the assessment and prevention of anesthesia overdose at high altitude. The study was approved by the ethics committee of the Fundación Cardioinfantil-Instituto de cardiología, Bogota, Colombia (approved number: 312017). © 2019 Medical Gas Research Published by Wolters Kluwer - Medknow.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.4103/2045-9912.248265
dc.identifier.issn20459912
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22568
dc.language.isoengspa
dc.publisherWolters Kluwer Medknow Publicationsspa
dc.relation.citationEndPage153
dc.relation.citationIssueNo. 4
dc.relation.citationStartPage150
dc.relation.citationTitleMedical Gas Research
dc.relation.citationVolumeVol. 8
dc.relation.ispartofMedical Gas Research, ISSN:20459912, Vol.8, No.4 (2018); pp. 150-153spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059933024&doi=10.4103%2f2045-9912.248265&partnerID=40&md5=44d292ddf34b1fce263bb3b9af486fdcspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAnesthetic agentspa
dc.subject.keywordSevofluranespa
dc.subject.keywordAdultspa
dc.subject.keywordAgespa
dc.subject.keywordAltitudespa
dc.subject.keywordArticlespa
dc.subject.keywordBispectral indexspa
dc.subject.keywordClinical articlespa
dc.subject.keywordCohort analysisspa
dc.subject.keywordColombiaspa
dc.subject.keywordDrug intoxicationspa
dc.subject.keywordDrug overdosespa
dc.subject.keywordFemalespa
dc.subject.keywordGeneral anesthesiaspa
dc.subject.keywordHumanspa
dc.subject.keywordInhalation anesthesiaspa
dc.subject.keywordIntraoperative awarenessspa
dc.subject.keywordMalespa
dc.subject.keywordMean alveolar concentrationspa
dc.subject.keywordMean arterial pressurespa
dc.subject.keywordOxygen saturationspa
dc.subject.keywordPatient safetyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProspective studyspa
dc.subject.keywordRespiratory tract parametersspa
dc.subject.keywordGeneral anesthesiaspa
dc.subject.keywordDrug overdosespa
dc.subject.keywordBiespectral indexspa
dc.subject.keywordMean alveolar concentrationspa
dc.subject.keywordAltitudespa
dc.subject.keywordInhalationspa
dc.subject.keywordIntraoperative awarenessspa
dc.titleFrequency of anesthetic overdose with mean alveolar concentration-guided anesthesia at high altitudespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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