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Enhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early life

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dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorCastellote, Cristinaspa
dc.creatorCastella, Margaridaspa
dc.creatorMoltó-Puigmartí, Carolinaspa
dc.creatorRivero, Montserratspa
dc.creatorPérez-Cano, Francisco J.spa
dc.creatorFranch, Àngelsspa
dc.date.accessioned2020-08-19T14:43:08Z
dc.date.available2020-08-19T14:43:08Z
dc.date.created2011-05-01spa
dc.description.abstractPrevious studies have demonstrated that the intake of a 1% conjugated linoleic acid (CLA) diet in an 80:20 mixture of cis-9,trans-11 and trans-10,cis-12 exerts age-specific effects on the immune system: immunoglobulin enhancement and proliferative down-modulation in neonatal and adult rats, respectively. The present study evaluates the influence of the same diet on antibody synthesis of early infant Wistar rats during suckling and/or after weaning. Dietary supplementation was performed during suckling and early infancy (4 weeks), only during suckling (3 weeks), or only in early infancy (1 week). CLA content in plasma and serum immunoglobulin (Ig) G, IgM and IgA concentration were determined. Proliferation, cytokines and Ig production were evaluated on isolated splenocytes. Cis-9,trans-11- and trans-10,cis-12-CLA isomers were detected in the plasma of all CLA-supplemented animals, and the highest content was quantified in those rats supplemented over the longest period. These rats also exhibited higher concentrations of serum IgG, IgM and IgA. Moreover, splenocytes from CLA-supplemented rats showed the highest IgM and IgG synthesis and interleukin (IL)-6 production, whereas their proliferative ability was lower. In summary, in infant rats, we observed both the enhance antibody synthesis previously reported in neonates, and the reduced lymphoproliferation previously reported in adults.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jnutbio.2010.04.005
dc.identifier.issnISSN: 0955-2863
dc.identifier.issnEISSN: 1873-4847
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/27647
dc.language.isoengspa
dc.publisherElsevierspa
dc.relation.citationEndPage501
dc.relation.citationIssueNo. 5
dc.relation.citationStartPage495
dc.relation.citationTitleJournal of Nutritional Biochemistry
dc.relation.citationVolumeVol. 22
dc.relation.ispartofJournal of Nutritional Biochemistry, ISSN: 0955-2863;EISSN: 1873-4847, Vol.22, No.5 (2011); pp. 495-501spa
dc.relation.urihttps://www.sciencedirect.com/science/article/abs/pii/S0955286310001038?via%3Dihubspa
dc.rights.accesRightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.accesoRestringido (Acceso a grupos específicos)spa
dc.sourceJournal of Nutritional Biochemistryspa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.keywordConjugated linoleic acidspa
dc.subject.keywordEarly lifespa
dc.subject.keywordImmunoglobulin synthesisspa
dc.subject.keywordLymphocyte proliferationspa
dc.titleEnhancement of antibody synthesis in rats by feeding cis-9,trans-11 conjugated linoleic acid during early lifespa
dc.title.TranslatedTitleMejora de la síntesis de anticuerpos en ratas mediante la alimentación con ácido linoleico conjugado cis-9, trans-11 durante la vida tempranaspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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