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Characterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34)

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dc.creatorMongui, Alvarospa
dc.creatorAngel, Diana I.spa
dc.creatorGallego, Ginaspa
dc.creatorReyes, Claudiaspa
dc.creatorMartinez, Paolaspa
dc.creatorGuhl, Felipespa
dc.creatorPatarroyo, Manuel A.spa
dc.date.accessioned2020-05-26T00:02:11Z
dc.date.available2020-05-26T00:02:11Z
dc.date.created2009spa
dc.description.abstractThis study describes the identification of the Plasmodium vivax rhoptry antigen Pv34 whose sequence was obtained based on homology comparison with the Plasmodium falciparum Pf34. The pv34 gene product was characterized by molecular biology and immunological techniques. Additionally, association of Pv34 to detergent-resistant microdomains (DRMs), expression in late blood-stage parasites and recognition of recombinant Pv34 (rPv34) by sera from P. vivax-infected Aotus monkeys and patients was assessed. Lymphoproliferation and cytokine secretion was also evaluated in individuals living in malaria endemic areas. Altogether, the data support carrying out further studies to assess the immunogenicity and protection-inducing ability of rPv34 as component of a multi-antigenic, multi-stage vaccine against vivax malaria. © 2009 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2009.10.034
dc.identifier.issn0264410X
dc.identifier.issn13588745
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23457
dc.language.isoengspa
dc.relation.citationEndPage421
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage415
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 28
dc.relation.ispartofVaccine, ISSN:0264410X, 13588745, Vol.28, No.2 (2009); pp. 415-421spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-70649093849&doi=10.1016%2fj.vaccine.2009.10.034&partnerID=40&md5=a74ebb3c1ffe22e37c9bd7bf88dba4c0spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordChloroquinespa
dc.subject.keywordindirecteng
dc.subject.keywordInterleukin 10spa
dc.subject.keywordInterleukin 2spa
dc.subject.keywordInterleukin 4spa
dc.subject.keywordInterleukin 5spa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordPrimaquinespa
dc.subject.keywordRecombinant plasmodium vivax 34 antigenspa
dc.subject.keywordRecombinant proteinspa
dc.subject.keywordTumor necrosis factor alphaspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordArticlespa
dc.subject.keywordBlood samplingspa
dc.subject.keywordCytokine releasespa
dc.subject.keywordDrug antigenicityspa
dc.subject.keywordHumanspa
dc.subject.keywordHumoral immunityspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordLymphocyte proliferationspa
dc.subject.keywordMolecular biologyspa
dc.subject.keywordMonkeyspa
dc.subject.keywordNonhumanspa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordPeripheral blood mononuclear cellspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPlasmodium vivax malariaspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein blood levelspa
dc.subject.keywordRabbitspa
dc.subject.keywordAdultspa
dc.subject.keywordAgedspa
dc.subject.keywordAnimalsspa
dc.subject.keywordBlottingeng
dc.subject.keywordCytokinesspa
dc.subject.keywordElectrophoresiseng
dc.subject.keywordFluorescent antibody techniqueeng
dc.subject.keywordHaplorhinispa
dc.subject.keywordHumansspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordRabbitsspa
dc.subject.keywordPf34 homologuespa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordVaccine candidatespa
dc.titleCharacterization and antigenicity of the promising vaccine candidate Plasmodium vivax 34 kDa rhoptry antigen (Pv34)spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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