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Tracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiology

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dc.creatorVasylyeva, Tetyana Ispa
dc.creatordu Plessis, Louisspa
dc.creatorPineda-Peña, Andrea Cspa
dc.creatorKühnert, Denisespa
dc.creatorLemey, Philippespa
dc.creatorVandamme, Anne-Miekespa
dc.creatorGomes, Perpétuaspa
dc.creatorCamacho, Ricardo Jspa
dc.creatorPybus, Oliver Gspa
dc.creatorAbecasis, Ana Bspa
dc.creatorFaria, Nuno Rspa
dc.date.accessioned2020-05-25T23:56:16Z
dc.date.available2020-05-25T23:56:16Z
dc.date.created2019spa
dc.description.abstractBackground: Estimation of temporal changes in human immunodeficiency virus (HIV) transmission patterns can help to elucidate the impact of preventive strategies and public health policies. Methods: Portuguese HIV-1 subtype B and G pol genetic sequences were appended to global reference data sets to identify country-specific transmission clades. Bayesian birth-death models were used to estimate subtype-specific effective reproductive numbers (Re). Discrete trait analysis (DTA) was used to quantify mixing among transmission groups. Results: We identified 5 subtype B Portuguese clades (26-79 sequences) and a large monophyletic subtype G Portuguese clade (236 sequences). We estimated that major shifts in HIV-1 transmission occurred around 1999 (95% Bayesian credible interval [BCI], 1998-2000) and 2000 (95% BCI, 1998-2001) for subtypes B and G, respectively. For subtype B, Re dropped from 1.91 (95% BCI, 1.73-2.09) to 0.62 (95% BCI,.52-.72). For subtype G, Re decreased from 1.49 (95% BCI, 1.39-1.59) to 0.72 (95% BCI,. 63-.8). The DTA suggests that people who inject drugs (PWID) and heterosexuals were the source of most ( and gt;80%) virus lineage transitions for subtypes G and B, respectively. Conclusions: The estimated declines in Re coincide with the introduction of highly active antiretroviral therapy and the scale-up of harm reduction for PWID. Inferred transmission events across transmission groups emphasize the importance of prevention efforts for bridging populations. © 2019 The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1093/infdis/jiz085
dc.identifier.issn00221899
dc.identifier.issn15376613
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22379
dc.language.isoengspa
dc.publisherOxford University Pressspa
dc.relation.citationEndPage243
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage233
dc.relation.citationTitleJournal of Infectious Diseases
dc.relation.citationVolumeVol. 220
dc.relation.ispartofJournal of Infectious Diseases, ISSN:00221899, 15376613, Vol.220, No.2 (2019); pp. 233-243spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85068468380&doi=10.1093%2finfdis%2fjiz085&partnerID=40&md5=ad9936e0a644fcdc6b6b91652ea9aed5spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordPol proteinspa
dc.subject.keywordBayes theoremspa
dc.subject.keywordGeneticsspa
dc.subject.keywordHumanspa
dc.subject.keywordHuman immunodeficiency virus 1spa
dc.subject.keywordHuman immunodeficiency virus infectionspa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPortugalspa
dc.subject.keywordPublic healthspa
dc.subject.keywordVirologyspa
dc.subject.keywordBayes Theoremspa
dc.subject.keywordHIV Infectionsspa
dc.subject.keywordHIV-1spa
dc.subject.keywordHumansspa
dc.subject.keywordMolecular Epidemiologyspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPol Gene Productseng
dc.subject.keywordPortugalspa
dc.subject.keywordPublic Healthspa
dc.subject.keywordEpidemiologyspa
dc.subject.keywordHarm reductionspa
dc.subject.keywordHIVspa
dc.subject.keywordPhylodynamicsspa
dc.subject.keywordPortugalspa
dc.subject.keywordReproductive numberspa
dc.subject.keywordTransmission groupsspa
dc.titleTracing the Impact of Public Health Interventions on HIV-1 Transmission in Portugal Using Molecular Epidemiologyspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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