Ítem
Acceso Abierto

Molecular mimicry and autoimmunity

Mostrar el registro sencillo de la publicación
dc.creatorRojas Quintana, Manuel Eduardospa
dc.creatorRestrepo-Jiménez, Paulaspa
dc.creatorMonsalve Carmona, Diana Marcelaspa
dc.creatorPacheco Nieva, Yovana
dc.creatorAcosta Ampudia, Yeny Yasbleidyspa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorLeung, Patrick S.C.spa
dc.creatorAnsari, Aftab A.spa
dc.creatorGershwin, M. Ericspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-05-25T23:55:55Z
dc.date.available2020-05-25T23:55:55Z
dc.date.created2018spa
dc.description.abstractMolecular mimicry is one of the leading mechanisms by which infectious or chemical agents may induce autoimmunity. It occurs when similarities between foreign and self-peptides favor an activation of autoreactive T or B cells by a foreign-derived antigen in a susceptible individual. However, molecular mimicry is unlikely to be the only underlying mechanism for autoimmune responses; other factors such as breach in central tolerance, non-specific bystander activation, or persistent antigenic stimuli (amongst others) may also contribute to the development of autoimmune diseases. Host genetics, exposure to microbiota and environmental chemicals are additional links to our understanding of molecular mimicry. Our current knowledge of the detailed mechanisms of molecular mimicry is limited by the issues of prolonged periods of latency before the appearance of disease, the lack of enough statistical power in epidemiological studies, the limitations of the potential role of genetics in human studies, the relevance of inbred murine models to the diverse human population and especially the limited technology to systematically dissect the human T-cell repertoire and B-cell responses. Nevertheless, studies on the role of autoreactive T-cells that are generated secondary to molecular mimicry, the diversity of the T-cell receptor repertoires of auto-reactive T-cells, the role of exposure to cryptic antigens, the generation of autoimmune B-cell responses, the interaction of microbiota and chemical adjuvants with the host immune systems all provide clues in advancing our understanding of the molecular mechanisms involved in the evolving concept of molecular mimicry and also may potentially aid in the prevention and treatment of autoimmune diseases. © 2018 The Authorseng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jaut.2018.10.012
dc.identifier.issn10959157
dc.identifier.issn08968411
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22261
dc.language.isoengspa
dc.publisherAcademic Pressspa
dc.relation.citationEndPage123
dc.relation.citationStartPage100
dc.relation.citationTitleJournal of Autoimmunity
dc.relation.citationVolumeVol. 95
dc.relation.ispartofJournal of Autoimmunity, ISSN:10959157, 08968411, Vol.95,(2018); pp. 100-123spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85059332875&doi=10.1016%2fj.jaut.2018.10.012&partnerID=40&md5=e8d56134df82078aa74f1a54eb59dbeaspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordVaccinespa
dc.subject.keywordviraleng
dc.subject.keywordbacterialeng
dc.subject.keywordantigeneng
dc.subject.keywordAutoantibodyspa
dc.subject.keywordt-celleng
dc.subject.keywordAutoantigenspa
dc.subject.keywordBacterial antigenspa
dc.subject.keywordLymphocyte antigen receptorspa
dc.subject.keywordVirus antigenspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordAutoimmune hepatitisspa
dc.subject.keywordAutoimmune liver diseasespa
dc.subject.keywordAutoimmune thyroiditisspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCross reactionspa
dc.subject.keywordGuillain barre syndromespa
dc.subject.keywordHumanspa
dc.subject.keywordInsulin dependent diabetes mellitusspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordMultiple sclerosisspa
dc.subject.keywordNonhumanspa
dc.subject.keywordPrimary biliary cirrhosisspa
dc.subject.keywordPriority journalspa
dc.subject.keywordReviewspa
dc.subject.keywordRheumatoid arthritisspa
dc.subject.keywordSjoegren syndromespa
dc.subject.keywordSystemic lupus erythematosusspa
dc.subject.keywordSystemic sclerosisspa
dc.subject.keywordAnimalspa
dc.subject.keywordAutoimmune diseasespa
dc.subject.keywordB lymphocytespa
dc.subject.keywordBiosynthesisspa
dc.subject.keywordGene expressionspa
dc.subject.keywordGeneticsspa
dc.subject.keywordImmunologyspa
dc.subject.keywordMicrobiologyspa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordMousespa
dc.subject.keywordT lymphocytespa
dc.subject.keywordVirologyspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordAntigenseng
dc.subject.keywordAutoantibodiesspa
dc.subject.keywordAutoantigensspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordB-lymphocytesspa
dc.subject.keywordCross reactionsspa
dc.subject.keywordGene expressionspa
dc.subject.keywordHumansspa
dc.subject.keywordMicespa
dc.subject.keywordMolecular mimicryspa
dc.subject.keywordReceptorseng
dc.subject.keywordT-lymphocytesspa
dc.subject.keywordAutoimmune diseasesspa
dc.subject.keywordAutoimmunityspa
dc.subject.keywordCross reactionsspa
dc.subject.keywordCross-reactivityspa
dc.subject.keywordMolecular mimicryspa
dc.titleMolecular mimicry and autoimmunityspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
Archivos
Bloque original
Mostrando1 - 1 de 1
Miniatura
Nombre:
1-s2-0-S0896841118305365-main.pdf
Tamaño:
2.13 MB
Formato:
Adobe Portable Document Format
Descripción:
Descargar
Colecciones
Artículos