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Substance P and Calcitonin gene-related peptide expression in human periodontal ligament after root canal preparation with Reciproc Blue, WaveOne Gold, XP EndoShaper and hand files

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dc.creatorCaviedes-Bucheli J.spa
dc.creatorRios-Osorio N.spa
dc.creatorRey-Rojas M.spa
dc.creatorLaguna-Rivero F.spa
dc.creatorAzuero-Holguin M.M.spa
dc.creatorDiaz L.E.spa
dc.creatorCurtidor H.spa
dc.creatorCastaneda-Ramirez J.J.spa
dc.creatorMunoz H.R.spa
dc.date.accessioned2020-05-26T00:11:44Z
dc.date.available2020-05-26T00:11:44Z
dc.date.created2018spa
dc.description.abstractAim: To quantify Substance P (SP) and Calcitonin gene-related peptide (CGRP) expression in healthy human periodontal ligament from premolars after root canal preparation with Reciproc Blue, WaveOne Gold, XP EndoShaper and hand files. Methodology: A total of 50 human periodontal ligament samples were obtained from healthy mandibular premolars where extraction was indicated for orthodontic reasons. Prior to extraction, 40 of these premolars were equally divided into four groups, and root canals were prepared using four different systems: Reciproc Blue, WaveOne Gold, XP EndoShaper and a hand instrumentation technique. The remaining 10 healthy premolars were extracted without treatment and served as a negative control group. All periodontal ligament samples were processed, and SP and CGRP were measured by radioimmunoassay. The Kruskal–Wallis test was used to establish significant differences between groups and LSD post hoc comparisons were also performed. Results: Greater SP and CGRP values were found in the hand instrumentation group, followed by the XP EndoShaper, WaveOne Gold and the Reciproc groups. The lower SP and CGRP values were for the healthy periodontal ligament group. The Kruskal–Wallis test revealed significant differences between groups (P  less than  0.05). Post hoc Least Significant Difference (LSD) tests revealed significant differences (P  less than  0.05) in SP and CGRP expression between all the comparisons except for the Reciproc Blue and WaveOne Gold group (P > 0.05). Conclusion: All the root canal preparation techniques tested increased SP and CGRP expression in human periodontal ligament, with hand files and XP EndoShaper instruments being associated with greater neuropeptide release compared to Reciproc Blue and WaveOne Gold files. © 2018 International Endodontic Journal. Published by John Wiley and Sons Ltdeng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1111/iej.12952
dc.identifier.issn13652591
dc.identifier.issn01432885
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24328
dc.language.isoengspa
dc.publisherBlackwell Publishing Ltdspa
dc.relation.citationEndPage1366
dc.relation.citationIssueNo. 12
dc.relation.citationStartPage1358
dc.relation.citationTitleInternational Endodontic Journal
dc.relation.citationVolumeVol. 51
dc.relation.ispartofInternational Endodontic Journal, ISSN:13652591, 01432885, Vol.51, No.12 (2018); pp. 1358-1366spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85056124698&doi=10.1111%2fiej.12952&partnerID=40&md5=12e7cef674937eb78def5dd6655c3ed6spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCalcitonin gene related peptidespa
dc.subject.keywordSubstance pspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordBiosynthesisspa
dc.subject.keywordColombiaspa
dc.subject.keywordDental devicespa
dc.subject.keywordDevicesspa
dc.subject.keywordEquipment designspa
dc.subject.keywordHumanspa
dc.subject.keywordMandiblespa
dc.subject.keywordMaterials testingspa
dc.subject.keywordMetabolismspa
dc.subject.keywordPeriodontal ligamentspa
dc.subject.keywordPremolar toothspa
dc.subject.keywordProceduresspa
dc.subject.keywordRoot canal preparationspa
dc.subject.keywordTooth periapical diseasespa
dc.subject.keywordYoung adultspa
dc.subject.keywordAdolescentspa
dc.subject.keywordAdultspa
dc.subject.keywordBicuspidspa
dc.subject.keywordCalcitonin gene-related peptidespa
dc.subject.keywordColombiaspa
dc.subject.keywordDental instrumentsspa
dc.subject.keywordEquipment designspa
dc.subject.keywordHumansspa
dc.subject.keywordMandiblespa
dc.subject.keywordMaterials testingspa
dc.subject.keywordPeriapical periodontitisspa
dc.subject.keywordPeriodontal ligamentspa
dc.subject.keywordRoot canal preparationspa
dc.subject.keywordSubstance pspa
dc.subject.keywordYoung adultspa
dc.subject.keywordCalcitonin gene-related peptidespa
dc.subject.keywordHuman periodontal ligamentspa
dc.subject.keywordNeurogenic inflammationspa
dc.subject.keywordNeuropeptidesspa
dc.subject.keywordReciproc bluespa
dc.subject.keywordSubstance pspa
dc.subject.keywordSymptomatic apical periodontitisspa
dc.subject.keywordWaveone goldspa
dc.subject.keywordXp-endoshaperspa
dc.titleSubstance P and Calcitonin gene-related peptide expression in human periodontal ligament after root canal preparation with Reciproc Blue, WaveOne Gold, XP EndoShaper and hand filesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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