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Genome diversity, recombination, and virulence across the major lineages of Paracoccidioides

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dc.creatorMuñoz, José F.
dc.creatorFarrer, Rhys
dc.creatorDesjardins, Christopher
dc.creatorGallo, Juan E.
dc.creatorSykes, Sean
dc.creatorSakthikumar, Sharadha
dc.creatorMisas, Elizabeth
dc.creatorWhiston, Emily A.
dc.creatorBagagli, Eduardo
dc.creatorSoares, Celia M. A.
dc.creatorTeixeira, Marcus de Melo
dc.creatorTaylor, John W.
dc.creatorClay, Oliver K.
dc.creatorMcEwen, Juan Guillermo
dc.creatorCuomo, Christina
dc.creator.googleMuñoz, J.F.spa
dc.creator.googleFarrer, Rhys A.spa
dc.creator.googleDesjardins, Christopher A.spa
dc.creator.googleGallo, Juan E.spa
dc.creator.googleSykes, Seanspa
dc.creator.googleSakthikumar, Sharadhaspa
dc.creator.googleMisas, Elizabethspa
dc.creator.googleWhiston, Emily Aspa
dc.creator.googleBagagli, Eduardospa
dc.creator.googleSoares, Celia M. Aspa
dc.creator.googleTeixeira, Marcus de M.spa
dc.creator.googleTaylor, John W.spa
dc.creator.googleClay, Oliver K.spa
dc.creator.googleMcEwen, Juan G.spa
dc.creator.googleCuomo, Christina A.spa
dc.date.accessioned2020-05-11T23:21:04Z
dc.date.available2020-05-11T23:21:04Z
dc.date.created2016
dc.date.issued2016
dc.description.abstractThe Paracoccidioides genus includes two species of thermally dimorphic fungi that cause paracoccidioidomycosis, a neglected health-threatening human systemic mycosis endemic to Latin America. To examine the genome evolution and the diversity of Paracoccidioides spp., we conducted whole-genome sequencing of 31 isolates representing the phylogenetic, geographic, and ecological breadth of the genus. These samples included clinical, environmental and laboratory reference strains of the S1, PS2, PS3, and PS4 lineages of P. brasiliensis and also isolates of Paracoccidioides lutzii species. We completed the first annotated genome assemblies for the PS3 and PS4 lineages and found that gene order was highly conserved across the major lineages, with only a few chromosomal rearrangements. Comparing whole-genome assemblies of the major lineages with single-nucleotide polymorphisms (SNPs) predicted from the remaining 26 isolates, we identified a deep split of the S1 lineage into two clades we named S1a and S1b. We found evidence for greater genetic exchange between the S1b lineage and all other lineages; this may reflect the broad geographic range of S1b, which is often sympatric with the remaining, largely geographically isolated lineages. In addition, we found evidence of positive selection for the GP43 and PGA1 antigen genes and genes coding for other secreted proteins and proteases and lineage-specific loss-of-function mutations in cell wall and protease genes; these together may contribute to virulence and host immune response variation among natural isolates of Paracoccidioides spp. These insights into the recent evolutionary events highlight important differences between the lineages that could impact the distribution, pathogenicity, and ecology of Paracoccidioides. © 2016 Muñoz et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1128/mSphere.00213-16
dc.identifier.issn2379-5042
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/21961
dc.language.isoengspa
dc.relation.citationIssueNo. 5
dc.relation.citationTitlemSphere
dc.relation.citationVolumeVol. 1
dc.relation.ispartofmSphere, ISSN: 2379-5042 Vol. 1, No. 5 (Septiembre 2016); 18 ppspa
dc.relation.urihttps://msphere.asm.org/content/1/5/e00213-16spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosario
dc.source.reponamereponame:Repositorio Institucional EdocUR
dc.subject.ddcIncidencia & prevención de la enfermedadspa
dc.subject.keywordParacoccidioidesspa
dc.subject.keywordEvolutionspa
dc.subject.keywordGenetic recombinationspa
dc.subject.keywordGenome analysisspa
dc.subject.keywordMycologyspa
dc.subject.keywordPopulation geneticsspa
dc.titleGenome diversity, recombination, and virulence across the major lineages of Paracoccidioidesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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