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Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue
| dc.creator | Monguia, Alvaro | spa |
| dc.creator | Perez-Leal, Oscar | spa |
| dc.creator | Rojas-Caraballo, Jose | spa |
| dc.creator | Angel, Diana I. | spa |
| dc.creator | Cortes, Jimena | spa |
| dc.creator | Patarroyo, Manuel A. | spa |
| dc.date.accessioned | 2020-08-06T16:20:16Z | |
| dc.date.available | 2020-08-06T16:20:16Z | |
| dc.date.created | 2007-07-06 | spa |
| dc.description.abstract | Four Plasmodium species cause malaria in humans, Plasmodium falciparum being the most widely studied to date. All Plasmodium species have paired club-shaped organelles towards their apical extreme named rhoptries that contain many lipids and proteins which are released during target cell invasion. P. falciparum RhopH3 is a rhoptry protein triggering important immune responses in patients from endemic regions. It has also been shown that anti-RhopH3 antibodies inhibit in vitro invasion of erythrocytes. Recent immunisation studies in mice with the Plasmodium yoelii and Plasmodium berghei RhopH3 P. falciparum homologue proteins found that they are able to induce protection in murine models. This study described identifying and characterising RhopH3 protein in Plasmodium vivax; it is encoded by a seven exon gene and expressed during the parasite’s asexual stage. PvRhopH3 has similar processing to its homologue in P. falciparum and presents a cellular immunolocalisation pattern characteristic of rhoptry proteins. | eng |
| dc.format.mimetype | application/pdf | |
| dc.identifier.doi | https://doi.org/10.1016/j.bbrc.2007.05.015 | |
| dc.identifier.issn | ISSN: 0006-291X | |
| dc.identifier.issn | EISSN: 1090-2104 | |
| dc.identifier.uri | https://repository.urosario.edu.co/handle/10336/25942 | |
| dc.language.iso | eng | spa |
| dc.publisher | Elsevier | spa |
| dc.relation.citationEndPage | 866 | |
| dc.relation.citationIssue | No. 3 | |
| dc.relation.citationStartPage | 861 | |
| dc.relation.citationTitle | Biochemical and Biophysical Research Communications | |
| dc.relation.citationVolume | Vol. 358 | |
| dc.relation.ispartof | Biochemical and Biophysical Research Communications, ISSN: 0006-291X;EISSN: 1090-2104, Vol.358, No.3 (2007); pp.861-866 | spa |
| dc.relation.uri | https://www.sciencedirect.com/science/article/abs/pii/S0006291X07009576 | spa |
| dc.rights.accesRights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.acceso | Restringido (Acceso a grupos específicos) | spa |
| dc.source | Biochemical and Biophysical Research Communications | spa |
| dc.source.instname | instname:Universidad del Rosario | |
| dc.source.reponame | reponame:Repositorio Institucional EdocUR | |
| dc.subject.keyword | Malaria | spa |
| dc.subject.keyword | Plasmodium vivax | spa |
| dc.subject.keyword | Rhoptry | spa |
| dc.subject.keyword | RhopH3 | spa |
| dc.subject.keyword | Vaccine candidate | spa |
| dc.title | Identifying and characterising the Plasmodium falciparum RhopH3 Plasmodium vivax homologue | spa |
| dc.title.TranslatedTitle | Identificación y caracterización del homólogo de Plasmodium falciparum RhopH3 Plasmodium vivax | spa |
| dc.type | article | eng |
| dc.type.hasVersion | info:eu-repo/semantics/publishedVersion | |
| dc.type.spa | Artículo | spa |
