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Integrating metagenomics and metabolomics to study the gut microbiome and host relationships in sports across different energy systems

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dc.creatorRamirez Gonzalez, Juan Davidspa
dc.creatorCala, Mónica P.spa
dc.creatorVega, Laura Camilaspa
dc.creatorPardo-Rodriguez, Danielspa
dc.creatorAya, Vivianaspa
dc.date.accessioned2025-07-21T16:48:24Z
dc.date.available2025-07-21T16:48:24Z
dc.date.created2025-12-01spa
dc.date.issued2025-12-01spa
dc.description.abstractThe gut microbiome plays a critical role in modulating host metabolism, influencing energy production, nutrient utilization, and overall physiological adaptation. In athletes, these microbial functions may be further specialized to meet the unique metabolic demands of different sports disciplines. This study explored the role of the gut microbiome in modulating host metabolism among Colombian athletes by comparing elite weightlifters (n?=?16) and cyclists (n?=?13) through integrative omics analysis. Fecal and plasma samples collected one month before an international event underwent metagenomic, metabolomic, and lipidomic profiling. Metagenomic analysis revealed significant microbial pathways, including L-arginine biosynthesis III and fatty acid biosynthesis initiation. Key metabolic pathways, such as phenylalanine, tyrosine, and tryptophan biosynthesis; arginine biosynthesis; and folate biosynthesis, were enriched in both athlete groups. Plasma metabolomics and lipidomics revealed distinct metabolic profiles and a separation between athlete types through multivariate models, with lipid-related pathways such as lipid droplet formation and glycolipid synthesis driving the differences. Notably, elevated carnitine, amino acid, and glycerolipid levels in weightlifters suggest energy system-specific metabolic adaptations. These findings underscore the complex relationship between the gut microbiota composition and metabolic responses tailored to athletic demands, laying the groundwork for personalized strategies to optimize performance. This research highlights the potential for targeted modulation of the gut microbiota as a basis for tailored interventions to support specific energy demands in athletic disciplines.eng
dc.format.mimetypeapplication/pdfspa
dc.identifier.doihttps://doi.org/10.1038/s41598-025-98973-2spa
dc.identifier.issn2045-2322spa
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/46084
dc.language.isoengspa
dc.publisherNature Waterspa
dc.relation.ispartofScientific Reports volume 15, Article number: 15356 (2025)spa
dc.relation.urihttps://www.nature.com/articles/s41598-025-98973-2spa
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internationalspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccessspa
dc.rights.accesoAbierto (Texto Completo)spa
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/spa
dc.sourceScientific Reportsspa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordGut microbiomeeng
dc.subject.keywordAthleteseng
dc.subject.keywordMetabolomicseng
dc.subject.keywordMetagenomicseng
dc.subject.keywordLipidomicseng
dc.subject.keywordSportseng
dc.titleIntegrating metagenomics and metabolomics to study the gut microbiome and host relationships in sports across different energy systemsspa
dc.typearticlespa
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersionspa
dc.type.spaArtículo de Investigaciónspa
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