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Immunological profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an infected Plasmodium berghei mouse model

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dc.creatorYandar, Nubiaspa
dc.creatorPastorin, Giorgiaspa
dc.creatorPrato, Mauriziospa
dc.creatorBianco, Albertospa
dc.creatorPatarroyo, Manuel Elkinspa
dc.creatorLozano, José Manuelspa
dc.date.accessioned2020-05-26T00:02:05Z
dc.date.available2020-05-26T00:02:05Z
dc.date.created2008spa
dc.description.abstractWe have covalently conjugated an N-terminus Plasmodium vivax apical membrane antigen-1 (AMA-1) peptide to functionalized carbon nanotubes (f-CNT). Immunological characterization of this molecular conjugate revealed that the immunogen-AMA-1 peptide was appropriately presented after being conjugated to CNTs as well as being recognized by BALB/c polyclonal antibodies. Subsequent experiments lead us to assess the AMA-1 peptide alone, as well as the CNT-peptide conjugate regarding rodent malarial infection. Remarkably, the peptide effectively controlled and delayed Plasmodium berghei-challenged animals' parasitaemia. The peptide-CNT conjugate displayed similar immunological properties to the peptide alone by protecting or delaying malarial infection. The peptide presentation by f-CNT to the immune system thus constitutes a promising approach for synthetic malarial vaccine formulation since the immunogen peptide conformation is well preserved. © 2008 Elsevier Ltd. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.vaccine.2008.08.014
dc.identifier.issn0264410X
dc.identifier.issn13588745
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23447
dc.language.isoengspa
dc.relation.citationEndPage5873
dc.relation.citationIssueNo. 46
dc.relation.citationStartPage5864
dc.relation.citationTitleVaccine
dc.relation.citationVolumeVol. 26
dc.relation.ispartofVaccine, ISSN:0264410X, 13588745, Vol.26, No.46 (2008); pp. 5864-5873spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-53449093079&doi=10.1016%2fj.vaccine.2008.08.014&partnerID=40&md5=f24cf4ad2c3fdb0f0fb8cc9ebd87a1a3spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordApical membrane antigen 1spa
dc.subject.keywordprotozoaneng
dc.subject.keywordDrug carrierspa
dc.subject.keywordPolyclonal antibodyspa
dc.subject.keywordAmino terminal sequencespa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordArticlespa
dc.subject.keywordBagg albino mousespa
dc.subject.keywordConjugationspa
dc.subject.keywordControlled studyspa
dc.subject.keywordDrug delivery systemspa
dc.subject.keywordDrug structurespa
dc.subject.keywordFemalespa
dc.subject.keywordImmune systemspa
dc.subject.keywordImmunogenicityspa
dc.subject.keywordMalariaspa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordPlasmodium bergheispa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordPriority journalspa
dc.subject.keywordAllelesspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntigenseng
dc.subject.keywordBlottingeng
dc.subject.keywordCytokinesspa
dc.subject.keywordDrug delivery systemsspa
dc.subject.keywordEnzyme-linked immunosorbent assayspa
dc.subject.keywordFemalespa
dc.subject.keywordFluorescent antibody techniquespa
dc.subject.keywordGeneseng
dc.subject.keywordHla-dr antigensspa
dc.subject.keywordMalariaspa
dc.subject.keywordMalaria vaccinesspa
dc.subject.keywordMembrane proteinsspa
dc.subject.keywordMicespa
dc.subject.keywordMiceeng
dc.subject.keywordMicroscopyeng
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordNanotubesspa
dc.subject.keywordPlasmodium bergheispa
dc.subject.keywordPlasmodium vivaxspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordVaccineseng
dc.subject.keywordApical membrane antigen 1 (ama-1)spa
dc.subject.keywordFunctionalized carbon nanotubes (f-cnt)spa
dc.subject.keywordSynthetic vaccine delivery systemspa
dc.titleImmunological profile of a Plasmodium vivax AMA-1 N-terminus peptide-carbon nanotube conjugate in an infected Plasmodium berghei mouse modelspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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