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Recombination rate variation shapes barriers to introgression across butterfly genomes

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dc.creatorMartin, Simon H.spa
dc.creatorDavey, John W.spa
dc.creatorSalazar, Camilospa
dc.creatorJiggins, Chris Dspa
dc.date.accessioned2020-05-25T23:58:11Z
dc.date.available2020-05-25T23:58:11Z
dc.date.created2019spa
dc.description.abstractHybridisation and introgression can dramatically alter the relationships among groups of species, leading to phylogenetic discordance across the genome and between populations. Introgression can also erode species differences over time, but selection against introgression at certain loci acts to maintain postmating species barriers. Theory predicts that species barriers made up of many loci throughout the genome should lead to a broad correlation between introgression and recombination rate, which determines the extent to which selection on deleterious foreign alleles will affect neutral alleles at physically linked loci. Here, we describe the variation in genealogical relationships across the genome among three species of Heliconius butterflies: H. melpomene (mel), H. cydno (cyd), and H. timareta (tim), using whole genomes of 92 individuals, and ask whether this variation can be explained by heterogeneous barriers to introgression. We find that species relationships vary predictably at the chromosomal scale. By quantifying recombination rate and admixture proportions, we then show that rates of introgression are predicted by variation in recombination rate. This implies that species barriers are highly polygenic, with selection acting against introgressed alleles across most of the genome. In addition, long chromosomes, which have lower recombination rates, produce stronger barriers on average than short chromosomes. Finally, we find a consistent difference between two species pairs on either side of the Andes, which suggests differences in the architecture of the species barriers. Our findings illustrate how the combined effects of hybridisation, recombination, and natural selection, acting at multitudes of loci over long periods, can dramatically sculpt the phylogenetic relationships among species. © 2019 Martin et al.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1371/journal.pbio.2006288
dc.identifier.issn15449173
dc.identifier.issn15457885
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22819
dc.language.isoengspa
dc.publisherPublic Library of Sciencespa
dc.relation.citationIssueNo. 2
dc.relation.citationTitlePLoS Biology
dc.relation.citationVolumeVol. 17
dc.relation.ispartofPLoS Biology, ISSN:15449173, 15457885, Vol.17, No.2 (2019)spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85061272706&doi=10.1371%2fjournal.pbio.2006288&partnerID=40&md5=1d1b61a6e1f40ebb4edb17af2595698cspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdulteng
dc.subject.keywordInsecteng
dc.subject.keywordAlleleeng
dc.subject.keywordPopulationeng
dc.subject.keywordGeneticeng
dc.subject.keywordChromosomeeng
dc.subject.keywordFemaleeng
dc.subject.keywordGenomeeng
dc.subject.keywordHumaneng
dc.subject.keywordHuman experimenteng
dc.subject.keywordIntrogressioneng
dc.subject.keywordMajor clinical studyeng
dc.subject.keywordMaleeng
dc.subject.keywordNatural selectioneng
dc.subject.keywordNonhumaneng
dc.subject.keywordAnimaleng
dc.subject.keywordButterflyeng
dc.subject.keywordGene floweng
dc.subject.keywordGenetic recombinationspa
dc.subject.keywordGenetic selectionspa
dc.subject.keywordGeneticseng
dc.subject.keywordInsect chromosomeeng
dc.subject.keywordInsect genomeeng
dc.subject.keywordPopulation geneticseng
dc.subject.keywordSpecies differenceeng
dc.subject.keywordButterflieseng
dc.subject.keywordGene floweng
dc.subject.keywordPhylogenyeng
dc.subject.keywordRecombinationeng
dc.subject.keywordSelectioneng
dc.subject.keywordSpecies specificityeng
dc.titleRecombination rate variation shapes barriers to introgression across butterfly genomesspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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