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Epidemiological history and genomic characterization of non-D1 HBV strains identified in Iran

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dc.creatorPineda-Peña, Andrea-Clemenciaspa
dc.creatorFaria, Nuno Rodriguesspa
dc.creatorMina, Thomasspa
dc.creatorAmini-Bavil-Olyaee, Samadspa
dc.creatorAlavian, Seyed Moayedspa
dc.creatorLemey, Philippespa
dc.creatorMaes, Pietspa
dc.creatorVan Ranst, Marcspa
dc.creatorPourkarim, Mahmoud Rezaspa
dc.date.accessioned2020-05-25T23:56:04Z
dc.date.available2020-05-25T23:56:04Z
dc.date.created2015spa
dc.description.abstractBackground: Hepatitis B virus (HBV) has been classified into eight genotypes and forty subgenotypes. Genotype D of HBV is the most worldwide distributed genotype and HBV subgenotype D1 has been isolated from Iranian patients. Objective: To characterize for the first time complete genomes of recently emerged non-D1 strains in Iran. Study design: HBV complete genomes isolated from 9 Iranian HBV carriers were sequenced. Different diversities of the ORFs were mapped and evolutionary history relationships were investigated. Results: Phylogenetic analysis identified four D2 subgenotypes and five D3 subgenotypes of HBV in the studied patients. Of note, D2 strains clustered with strains from Lebanon and Syria. The time of the most recent common ancestor (TMRCA) of the first cluster of D2 was dated at 1953 (BCI. = 1926, 1976) while the second cluster was dated at 1947 (BCI. = 1911, 1978). All five Iranian D3 strains formed a monophyletic cluster with Indian strain and dated back to 1967 (BCI. = 1946, 1987). Surprisingly, two D3 strains had an adw2 subtype. Interestingly, more than 80% of the present strains showed precore mutations, while two isolates carried basal core promoter variation. Conclusion: Iranian D2 and D3 isolates were introduced on at least two and one occasion in Iran and diverged from west and south Asian HBV strains, respectively. Considering the impact of the different (sub) genotypes on clinical outcome, exploring the distinct mutational patterns of Iranian D1 and non-D1 strains is of clinical importance. © 2014 Elsevier B.V.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.jcv.2014.12.010
dc.identifier.issn13866532
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22312
dc.language.isoengspa
dc.publisherElsevier B.V.spa
dc.relation.citationEndPage41
dc.relation.citationStartPage38
dc.relation.citationTitleJournal of Clinical Virology
dc.relation.citationVolumeVol. 63
dc.relation.ispartofJournal of Clinical Virology, ISSN:13866532, Vol.63,(2015); pp. 38-41spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84921261794&doi=10.1016%2fj.jcv.2014.12.010&partnerID=40&md5=e42d2fc20092fe5af105f5a4754a3fddspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordAdultspa
dc.subject.keywordmoleculareng
dc.subject.keywordClinical articlespa
dc.subject.keywordEpidemicspa
dc.subject.keywordGene mappingspa
dc.subject.keywordGene sequencespa
dc.subject.keywordGenetic variabilityspa
dc.subject.keywordGenotypespa
dc.subject.keywordHepatitis b virusspa
dc.subject.keywordHumanspa
dc.subject.keywordIndianspa
dc.subject.keywordIranspa
dc.subject.keywordLebanonspa
dc.subject.keywordMalespa
dc.subject.keywordNucleotide sequencespa
dc.subject.keywordOpen reading framespa
dc.subject.keywordPhylogenyspa
dc.subject.keywordPriority journalspa
dc.subject.keywordPromoter regionspa
dc.subject.keywordSyrian arab republicspa
dc.subject.keywordVirus genomespa
dc.subject.keywordVirus isolationspa
dc.subject.keywordVirus mutationspa
dc.subject.keywordVirus strainspa
dc.subject.keywordChemistryspa
dc.subject.keywordClassificationspa
dc.subject.keywordCluster analysisspa
dc.subject.keywordDna sequencespa
dc.subject.keywordFemalespa
dc.subject.keywordGeneticsspa
dc.subject.keywordGenotypespa
dc.subject.keywordHepatitis bspa
dc.subject.keywordHepatitis b virusspa
dc.subject.keywordHeterozygotespa
dc.subject.keywordIsolation and purificationspa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordMolecular evolutionspa
dc.subject.keywordMolecular geneticsspa
dc.subject.keywordSequence homologyspa
dc.subject.keywordVirologyspa
dc.subject.keywordVirus dnaspa
dc.subject.keywordAdultspa
dc.subject.keywordCarrier statespa
dc.subject.keywordCluster analysisspa
dc.subject.keywordDnaeng
dc.subject.keywordEvolutioneng
dc.subject.keywordFemalespa
dc.subject.keywordGenetic variationspa
dc.subject.keywordGenomeeng
dc.subject.keywordGenotypespa
dc.subject.keywordHepatitis bspa
dc.subject.keywordHepatitis b virusspa
dc.subject.keywordHumansspa
dc.subject.keywordIranspa
dc.subject.keywordMalespa
dc.subject.keywordMiddle agedspa
dc.subject.keywordMolecular epidemiologyspa
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordPhylogenyspa
dc.subject.keywordSequence analysiseng
dc.subject.keywordSequence homologyspa
dc.subject.keywordAncestorspa
dc.subject.keywordD2spa
dc.subject.keywordD3spa
dc.subject.keywordEvolutionspa
dc.subject.keywordHepatitis b virusspa
dc.subject.keywordIranspa
dc.subject.keywordMutationspa
dc.titleEpidemiological history and genomic characterization of non-D1 HBV strains identified in Iranspa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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