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A Maurer's cleft-associated Plasmodium falciparum membrane-associated histidine-rich protein peptide specifically interacts with the erythrocyte membrane

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dc.creatorGarcía, Jeisonspa
dc.creatorCurtidor, Hernandospa
dc.creatorGil, Olga L.spa
dc.creatorVanegas, Magnoliaspa
dc.creatorPatarroyo, Manuel E.spa
dc.date.accessioned2020-05-26T00:02:36Z
dc.date.available2020-05-26T00:02:36Z
dc.date.created2009spa
dc.description.abstractThe membrane-associated histidine-rich protein-1 (MAHRP-1) is a Maurer's cleft-resident molecule that has been recently described as an important protein for the trafficking of PfEMP-1 to infected erythrocyte membrane, a major virulence factor. We have studied the specific interactions between 20-mer-long synthetic peptides spanning the complete MAHRP-1 sequence and erythrocytes. A high-activity binding peptide (HABP) with saturable binding to a 46-kDa erythrocyte membrane protein was identified and its binding was affected by chymotrypsin treatment. Random coil and ?-helical features were found in the HABP's structure. Our results suggest that MAHRP-1 specifically interacts with erythrocyte membrane through a 20-mer-long amino acid region, raising questions about this region's potential as a therapeutic target against malaria. © 2009 Elsevier Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.bbrc.2009.01.050
dc.identifier.issn0006291X
dc.identifier.issn10902104
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23505
dc.language.isoengspa
dc.relation.citationEndPage126
dc.relation.citationIssueNo. 1
dc.relation.citationStartPage122
dc.relation.citationTitleBiochemical and Biophysical Research Communications
dc.relation.citationVolumeVol. 380
dc.relation.ispartofBiochemical and Biophysical Research Communications, ISSN:0006291X, 10902104, Vol.380, No.1 (2009); pp. 122-126spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-59849116166&doi=10.1016%2fj.bbrc.2009.01.050&partnerID=40&md5=e70102eeb4d87406c39ac31ca50e3e0dspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordCarrier proteins and binding proteinsspa
dc.subject.keywordChymotrypsinspa
dc.subject.keywordErythrocyte membrane protein 1spa
dc.subject.keywordProtein habpspa
dc.subject.keywordProtein mahrp 1spa
dc.subject.keywordProtozoal proteinspa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordErythrocyte membranespa
dc.subject.keywordNonhumanspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordProtein analysisspa
dc.subject.keywordProtein bindingspa
dc.subject.keywordProtein interactionspa
dc.subject.keywordProtein localizationspa
dc.subject.keywordProtein structurespa
dc.subject.keywordAmino acid sequencespa
dc.subject.keywordAnimalsspa
dc.subject.keywordCarrier proteinsspa
dc.subject.keywordErythrocyte membranespa
dc.subject.keywordMolecular sequence dataspa
dc.subject.keywordPeptidesspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordAntimalarial candidatespa
dc.subject.keywordHigh-activity binding peptidespa
dc.subject.keywordMahrp-1spa
dc.subject.keywordMalariaspa
dc.subject.keywordMaurer's cleftsspa
dc.subject.keywordPlasmodium falciparumspa
dc.titleA Maurer's cleft-associated Plasmodium falciparum membrane-associated histidine-rich protein peptide specifically interacts with the erythrocyte membranespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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