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Convalescent plasma in Covid-19: Possible mechanisms of action.

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dc.creatorRojas Quintana, Manuel Eduardospa
dc.creatorRodríguez Velandia, Yhojan Alexisspa
dc.creatorMonsalve Carmona, Diana Marcela
dc.creatorAcosta Ampudia, Yeny Yasbleidyspa
dc.creatorCamacho, Bernardospa
dc.creatorGallo, Juan Estebanspa
dc.creatorRojas-Villarraga, Adrianaspa
dc.creatorRamírez Santana, Heily Carolinaspa
dc.creatorDiaz-Coronado, Juan Cspa
dc.creatorManrique, Rubenspa
dc.creatorMantilla, Ruben Dspa
dc.creatorShoenfeld, Yehudaspa
dc.creatorAnaya, Juan-Manuelspa
dc.date.accessioned2020-06-11T13:20:49Z
dc.date.available2020-06-11T13:20:49Z
dc.date.created2020spa
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible of the coronavirus disease 2019 (COVID-19) pandemic. Therapeutic options including antimalarials, antivirals, and vaccines are under study. Meanwhile the current pandemic has called attention over old therapeutic tools to treat infectious diseases. Convalescent plasma (CP) constitutes the first option in the current situation, since it has been successfully used in other coronaviruses outbreaks. Herein, we discuss the possible mechanisms of action of CP and their repercussion in COVID-19 pathogenesis, including direct neutralization of the virus, control of an overactive immune system (i.e., cytokine storm, Th1/Th17 ratio, complement activation) and immunomodulation of a hypercoagulable state. All these benefits of CP are expected to be better achieved if used in non-critically hospitalized patients, in the hope of reducing morbidity and mortality.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.autrev.2020.102554
dc.identifier.issn1873-0183
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/24587
dc.language.isoeng
dc.publisherElsevier BVspa
dc.relation.citationEndPage102554
dc.relation.citationStartPage102554
dc.relation.citationTitleAutoimmunity reviews
dc.relation.ispartofAutoimmunity reviews, ISSN:1873-0183 (2020); pp. 102554-102554spa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordACE-2 receptorspa
dc.subject.keywordCOVID-19spa
dc.subject.keywordConvalescent plasmaspa
dc.subject.keywordCoronavirusspa
dc.subject.keywordCytokinesspa
dc.subject.keywordIntravenous immunoglobulinsspa
dc.subject.keywordNeutralizing antibodiesspa
dc.subject.keywordSARS-Cov-2spa
dc.titleConvalescent plasma in Covid-19: Possible mechanisms of action.spa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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