Conferencia y eventos externos
URI permanente para esta colección
Examinar
Examinando Conferencia y eventos externos por Autor "Amaya-Amaya, J."
Mostrando1 - 10 de 10
Resultados por página
Opciones de clasificación
- ÍtemSolo MetadatosAB0403 Cigarette smoking and coffee consumption independently influence the risk of developing cardiovascular disease in systemic lupus erythematosus(2013-06) Amaya-Amaya, J.; Pérez-Fernández, J. L.; Molano González, Nicolás; Mantilla, R. D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE), a 50-fold than general population. Traditional risk factors, such as, cigarette smoking and dyslipidemia, are known but they cannot fully account for the increased risk. Instead, non-traditional risk factors, related to disease are also contributing. Varied results have been reported on the association between coffee drinking and CVD in the general population, with controversial results. Coffee consumption has not been evaluated systematically in SLE patients with CVD.
- ÍtemSolo MetadatosAB0405 Factors associated with lupus nephritis in a highly admixed population(2013-06) Pérez-Fernández, J. L.; Amaya-Amaya, J.; Molano González, Nicolás; Mantilla, R.-D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematous (SLE). Multiple clinical and serological risk and protective factors for LN have been identified in Caucasians.
- ÍtemSolo MetadatosAB0421 Cutaneous involvement in systemic lupus erythematosus.a latenttraitanalysis(2013-06) Molano González, Nicolás; Pérez-Fernández, J. L.; Amaya-Amaya, J.; Mantilla, R. D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Cutaneous involvement is one of the most frequent manifestations of systemic lupus erythematosus (SLE); however ethnicity may influence its prevalence and clinical expression.
- ÍtemSolo MetadatosFRI0055 The influence of cigarette smoking on disease activity and joint erosions in rheumatoid arthritis: a systematic review and meta-analysis.(2013-06) La Hoz, J. Castellanos-De; Amaya-Amaya, J.; Molano González, Nicolás; Gutiérrez-Infante, F.; Anaya, Juan-Manuel; Rojas-Villarraga, A.There is a clear causal relationship between tobacco smoking and rheumatoid arthritis (RA), supported by observational studies and systematic reviews ; however, the effect of smoking on disease activity and the development of joint surface erosions has not been clearly established. Current data are conflicting, with some studies reporting an increased activity and progression of erosions and others showing an opposite relationship.
- ÍtemSolo MetadatosFRI0409 Smoking and SjÖGren's Syndrome Are Predictors of Autoimmune Thyroid Disease in Systemic Lupus Erythematosus(2014-06) Franco, J.-S.; Amaya-Amaya, J.; Molano González, Nicolás; Rodríguez Jiménez, Mónica María del Pilar; Acosta Ampudia, Yeny Yasbleidy; Mantilla, R.D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Autoimmune thyroid disease (AITD) has been described as the most prevalent autoimmune disease (AD) as well as being associated with other organ-specific and non-organ specific ADs.
- ÍtemSolo MetadatosFRI0513 Does non - erosive rheumatoid arthritis exist ?(2013-06) Amaya-Amaya, J.; Calvo-Páramo, E.; Calderon-Páez, A.; Torralvo-Morato, G.; Calixto, O. J.; Mantilla, R. D.; Anaya, Juan-Manuel; Rojas-Villarraga, A.Background Erosions are the hallmark of rheumatoid arthritis (RA). Although most of erosions may occur within 2 years of onset of the disease, their progression does not correlate with the duration of RA. Moreover, information about non-erosive RA is ambiguous. Objectives To evaluate the prevalence and characteristics of non-erosive RA. Methods Since no agreement about the time-lag interval for erosions appearance in RA exists, and there is no universally accepted definition about it, a zero score in hands and feet X-ray at 5 years of RA duration (by SvHD) was arbitrary considered as cut-off. Therefore, patients meeting these criteria were searched in a large cohort of RA patients (ACR, 1987). Metacarpophalangeal and metatarsophalangeal joints as well as wrist ultrasound (US) imaging (by OMERACT), and computed tomography (CT) were performed to confirm non-erosive RA. Spearman correlation coefficient, kappa analysis and Kendall´s W test were used to analyze data. Results Out of a total of 800 RA patients, 38 met inclusion criteria (4.75%). Most of them were women (76.3%). The median (IQR) of the age and duration of the disease were 52 (13) and 10 (8) years, respectively. Rheumatoid factor (RF) and anti-CCP antibodies were positive in 86.8% and 55.3%, respectively. Non-erosive RA was confirmed by the three methods in only 7 patients. There was no concordance between the three methods. For this sample, the sensitivity and specificity were 70% and 52% for US, and 58% and 57% for CT, respectively. Non-erosive RA was positively although weakly correlated with improved functional class according to the HAQ (r=0.32, p=0.045) and ANA positivity (r=0.43, p=0.030), and negatively correlated with activity of the disease (by RAPID3, r= -0.32, p=0.05), the use of biological therapy (r= -0.31, p=0.05) and RF (r= -0.36, p=0.042). Conclusions Non-erosive RA is rare (0.87%). A good functional class, ANA positivity, RAPID3 score, the use of biological therapy and RF influence the absence of erosions in long-standing RA (i.e., 5 years). Since there is a high variability and a lack of concordance exists among the imagining techniques, a consensus and unified definition about non-erosive RA are warranted.
- ÍtemSolo MetadatosSAT0463 Polyautoimmunity and clustering of autoimmune diseases(2013-06) Rojas-Villarraga, A.; Amaya-Amaya, J.; Lopez-Kleine, L.; Guarin-Parra, M.R.; Rodriguez-Rodriguez, A.; Mantilla, R.D.; Anaya, Juan-ManuelTo identify polyautoimmunity and to search for a grouping pattern of autoimmune diseases (ADs)
- ÍtemSolo MetadatosTHU0152 Polyautoimmunity and familial autoimmunity in rheumatoid arthritis(2015-06) Anaya, Juan-Manuel; Molano González, Nicolás; Rodríguez Jiménez, Mónica María del Pilar; Amaya-Amaya, J.; Acosta Ampudia, Yeny Yasbleidy; Reyes, B.; Mantilla, R.D.; Rojas-Villarraga, A.Background Polyautoimmunity (PolyA) is defined as the presence of more than one autoimmune disease (AD) in a single patient. When three or more ADs coexist, this extreme phenotype is called multiple autoimmune syndrome (MAS). The study of the same AD in nuclear families, also referred to as familial AD, has been extensively evaluated. However, the study of familial autoimmunity [(FAI) i.e., diverse ADs in a nuclear family] has been overlooked.
- ÍtemSolo MetadatosTHU0338 Does Age at Onset of SjöGren’s Syndrome Influence the Course and Severity of the Disease?(2013-06) Sarmiento-Monroy, J. C.; Amaya-Amaya, J.; Molano González, Nicolás; Mantilla, R.-D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Age at onset of disease (AOD) refers to the time period at which a patient experiences the first symptom(s). AOD varies among autoimmune diseases (ADs) and has been related to prognosis in some of them. Genetic, environmental and immunological factors may influence the AOD. Sjögren’s syndrome (SS) is considered an AD affecting mostly older women. However, information about how does AOD influence the course of SS is scarce.
- ÍtemSolo MetadatosTHU0480 Candidate gene discovery in autoimmunity by using extreme phenotypes and whole exome capture(2014-06) Arcos-Burgos, M.; Johar, A.; Amaya-Amaya, J.; Mantilla, R.D.; Andrews, D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground The multiple autoimmune syndrome (MAS) is defined as a condition characterized by the presence of three or more autoimmune diseases (ADs) in one patient. We demonstrated that MAS identifies extreme forms of ADs and is frequently clustered in families. MAS phenotypes present in families often displays Mendelian segregation ratios, representing crucial evidence for identifying major genes associated with autoimmunity.