Conferencia y eventos externos

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    Acceso Abierto
    004 - A Novel Familial Case of Diffuse Leukodystrophy Related to NDUFV1 Compound Heterozygous Mutations
    (2013-07-30) Rivera-Nieto, C.; Mateus, H.; Ortega-Recalde, O.; Fonseca Mendoza, Dora Janeth; Patiño, L.; Restrepo Fernández, Carlos Martín; Van der Knaap, M.; Laissue, P.
    Introduction: Mitochondrial leukodystrophy due to complex I deficiency is an entity with high genetic heterogeneity, the mutations of the gene NDUFV1 being one of the causes of this disease. It is an autosomal recessive entity that causes a variable phenotype, from a fatal neonatal onset to neurodegenerative disorders in adulthood. Problem Studied: We report 2 siblings, 5 and 2 years of age, with nystagmus, ataxia, impaired consciousness, hemiparesis, hyporeflexia, and psychomotor regression. In brain magnetic resonance imaging, signal abnormalities in large regions of the cerebral white matter were observed, suggesting a demyelinating disease. Materials and Methods: Genomic DNA was obtained from whole blood. The complete coding region of NDUFV1 was amplified in patients and their parents. Each amplicon was purified. Direct sequencing was performed. Intron 6 and exon 7 amplicons from patient 1 were cloned. A skin biopsy was performed in the mother. RNA was isolated. The NDUFV1 complementary DNA (cDNA) was amplified and directly sequenced. In silico analysis was performed. Following diagnosis, treatment with ubiquinol and riboflavin was started. Results: Both patients have the missense mutation c.1156C> T and the 42-base pair deletion in the gene NDUFV1. Bioinformatics analysis indicates that this deletion leads to messenger RNA (mRNA) synthesis with a premature stop codon. Probably, mutant mRNAs were recognized and degraded by the nonsense-mediated mRNA machinery. Analysis of the maternal NDUFV1 cDNA supports this hypothesis. Conclusion: Our results add information on the molecular basis and the phenotypic features of mitochondrial disease caused by NDUFV1 mutations. We can affirm that the mutations are causative of the phenotype. The patients are having a good therapeutic response to the treatment.
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    344 Point of Care Ultrasonography Training in Bogotá Emergency Medicine Residencies: The Unmet Need
    (2012-10) Henwood, P.C.; Norwood, B.R.; Genthon, A.A.; Silva, D.; Martinez, Y.B.; Granada, J.; Torres, J.; Romero, M.G.; Arbelaez, C.
    Background: As ultrasonography equipment has evolved toward increased portability, higher quality and lower cost, the field of point-of-care ultrasonography has grown, with numerous applications for emergency medicine practitioners. Competence in goal-directed ultrasonography image acquisition and interpretation is now a mandatory part of emergency medicine residency training in the United States and the United Kingdom. Appropriate training is a key component to the safe and effective use of this technology. In Colombia, emergency medicine is a relatively new specialty and leaders in the field have expressed interest in further integrating pointof-care ultrasonography into emergency medicine practice and resident training. Study Objectives: The objective of this study was to conduct a needs assessment to better understand the current state of point-of-care ultrasonography practice among all emergency medicine residency programs in Bogotá, Colombia. Methods: An ultrasonography needs assessment survey tool was distributed to all available residents of the 3 emergency medicine residency programs in Bogotá. The emergency medicine program directors, other physicians staffing the emergency departments, and several medical students rotating in the emergency departments were also surveyed. The needs assessment survey tool assessed the population’s experience with point-of-care ultrasonography, formal ultrasonography education, and interest in educational initiatives. Focus group sessions with 50% of emergency medicine residents in Bogotá were subsequently conducted to further qualify their perspective on the current state of diagnostic ultrasonography at each residency training site as it relates to their clinical and procedural practice. Partners Health care institutional review board exemption was obtained for this research. Results: Fifty four total clinicians (43 emergency physicians, 5 non-emergency physicians and 6 medical students) completed the survey. Twenty-nine participants (54%) had previously used an ultrasonography machine. Of all emergency medicine respondents, 24 had used ultrasonography, and trauma was the most common application. However, 52% of those who had used ultrasonography had performed less than 10 independent scans. Thirty-nine participants (72%) had received no formal ultrasonography training. Of respondents, 94% total (100% of emergency physicians) reported a high level of interest in learning point-of-care ultrasonography, particularly trauma and vascular access applications. The major barriers identified by those surveyed were the absence of teachers (83%), the absence of ultrasonography equipment (65%), and time limitations (39%). Focus group discussions revealed that the scope of clinical practice, especially regarding procedures performed by emergency physicians, varied between emergency departments and residencies, but all reported they wanted more training in the use of point-of-care ultrasonography to improve their practice and patient care. Conclusion: Emergency ultrasonography training and use in clinical practice among emergency medicine residencies in Bogotá is currently limited by the lack of ultrasonography equipment and educators. However, there is significant interest in educational initiatives among all residents and program directors. Further research into how to best integrate point-of-care ultrasonography into emergency medicine practice and resident training in Colombia is needed.
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    A new proposal of quality indicators for clinical engineering: A New Beginning for Human Health: Proceedings of the 25th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    (2003-01-01) Miguel Cruz, Antonio; Rodriguez, E.; Sanchez, M.C.; Tolkmitt, F.; Pozo, E.
    As we know from Stiefels paper '...we want to do our work right the first time and better the next time. But we really don't know whether we have done it right, or are doing it better, unless we have a measurement system for quality.' Unfortunately, there is little agreement in the standardization of indicators used for evaluation of organizations related to medical equipment management. And those that do the first steps, always walk on thin ice. With this paper, we suggest a set of five quality indicators for the control and the evaluation of management for medical equipment maintenance. The indicators proposed allow the organization, that applies them, to easily correct and adjust their management programs, with a strive for improvement in results and quality and broadening their experiences. The selection of the indicators was executed according to those that are most used among leading health care organizations. Sometimes the indicators are labeled differently but the basic idea is the same, and therefore the results can be compared competitively and the potential of an organization can be displayed.
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    AB0354 Subcutaneous abatacept in patients with rheumatoid arthritis: A real-life experience
    (2016-06) Sarmiento-Monroy, J.C.; Villota-Eraso, C.; Mantilla-Ribero, M.J.; Molano González, Nicolás; Rodríguez Jiménez, Mónica María del Pilar; Rojas-Villarraga, A.; Mantilla, R.D.
    Background Therapeutic guidelines draw heavily on evidence from randomized controlled trials undertaken in well-characterized, highly-selective populations and managed in tightly-controlled settings. As such, the extent to which therapeutic efficacy in real-life populations and routine care settings is often unclear
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    AB0403 Cigarette smoking and coffee consumption independently influence the risk of developing cardiovascular disease in systemic lupus erythematosus
    (2013-06) Amaya-Amaya, J.; Pérez-Fernández, J. L.; Molano González, Nicolás; Mantilla, R. D.; Rojas-Villarraga, A.; Anaya, Juan-Manuel
    Background Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE), a 50-fold than general population. Traditional risk factors, such as, cigarette smoking and dyslipidemia, are known but they cannot fully account for the increased risk. Instead, non-traditional risk factors, related to disease are also contributing. Varied results have been reported on the association between coffee drinking and CVD in the general population, with controversial results. Coffee consumption has not been evaluated systematically in SLE patients with CVD.
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    AB0405 Factors associated with lupus nephritis in a highly admixed population
    (2013-06) Pérez-Fernández, J. L.; Amaya-Amaya, J.; Molano González, Nicolás; Mantilla, R.-D.; Rojas-Villarraga, A.; Anaya, Juan-Manuel
    Background Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematous (SLE). Multiple clinical and serological risk and protective factors for LN have been identified in Caucasians.
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    AB0421 Cutaneous involvement in systemic lupus erythematosus.a latenttraitanalysis
    (2013-06) Molano González, Nicolás; Pérez-Fernández, J. L.; Amaya-Amaya, J.; Mantilla, R. D.; Rojas-Villarraga, A.; Anaya, Juan-Manuel
    Background Cutaneous involvement is one of the most frequent manifestations of systemic lupus erythematosus (SLE); however ethnicity may influence its prevalence and clinical expression.
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    Acceso Abierto
    Acceso Abierto: Experiencia de la Universidad del Rosario
    (2019-10-29) Lisowska Navarro, Malgorzata; El Acceso Abierto como una oportunidad para la visibilidad científica y posicionamiento institucional
    Presentación realizada en el evento "El Acceso Abierto como una oportunidad para la visibilidad científica y posicionamiento institucional" realizada en la Universidad Eafit en Bogotá - Colombia, donde se da a conocer la experiencia de la Universidad del Rosario en el campo de la Ciencia Abierta.
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    Acceso Abierto
    Acceso Abierto: Mitos y realidades del Acceso Abierto
    (2019-10-29) Lisowska Navarro, Malgorzata; Uribe-Tirado, Alejandro; Gonzalez-Perez, Maria Alejandra; Leal Fonseca, Diego Ernesto; El Acceso Abierto como una oportunidad para la visibilidad científica y posicionamiento institucional
    Conversatorio acerca de los mitos y realidades del Acceso Abierto en la Universidad Eafit. Dentro del cual se abordan desde las practicas de publicación en acceso abierto de la Universidad del rosario y la Universidad de Antioquia, que desafíos enfrentan las instituciones y la divulgación y generación de ciencia abierta.
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    Agencia Moral y Construcción de Paz
    (2017-01-01) Ramírez Rueda, Luisa Fernanda; Gutiérrez Peláez, Miguel
    En dos intentos previos de negociación de paz, como ahora, los gobiernos de Belisario Betancurt (1982-1986) y de Andrés Pastrana Arango (1998-2002) se situaron como mediadores de las relaciones entre los actores del conflicto y la sociedad civil. Posteriormente en ambos casos, se evidenció un fortalecimiento de la extrema derecha dando lugar al Genocidio de la Unión Patriótica, y al fortalecimiento del paramilitarismo y a las mayores cifras de desplazamiento forzado en la historia de Colombia. En ambos casos, una posible explicación del fracaso tiene que ver con la incapacidad de estos gobiernos para alinear a toda la sociedad con sus objetivos. Tras el último proceso de negociación emprendido por el gobierno de Juan Manuel Santos (2012-2016) con la guerrilla de las FARC (Fuerzas Armadas Revolucionarias de Colombia), el gobierno y la sociedad colombiana se enfrentan una vez más con el reto de reunir el apoyo suficiente para lograr una implementación exitosa los acuerdos logrados. Los resultados recientes del Plebiscito por la paz (Octubre de 2016) y el aumento registrado desde el 2016 en los asesinatos de líderes de izquierda, ponen en evidencia que el reto sigue vigente. Un aspecto a considerar consiste en que el involucramiento de la población en el proceso de construcción de paz depende de que exista un proceso de reflexión moral. Cuando no es así, la desconexión moral contribuye al rechazo de la población a las políticas de reparación y a la emergencia de comportamientos destructivos que amenazan el proceso. Esta ponencia explora la existencia de indicadores de desconexión moral y algunos factores predictores de la misma, así como su relación con al apoyo a los acuerdos de paz entre el gobierno y las FARC
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    Antidepressants in painful diabetic neuropathy
    (2008-08) Gutierrez Alvarez, A.M.; Moreno, C.B.
    Background: The incidence of diabetic neuropathy increases withthe duration of diabetes and the degree of hyperglycaemia. Pain isone of the most common and incapacitating symptoms of diabeticneuropathy and its pharmacological control is complex. The effec-tiveness of antidepressive agents has been described in differenttypes of neuropathic pain, but their effectiveness when used as anal-gesics in painful diabetic neuropathy still remains controversial.The objective was to review the possible role of antidepressiveagents for the treatment of pain in diabetic peripheral neuropathy.Thus, this work has consisted of meta-analysis for determiningwhich antidepressive agent had the best analgesic potential for man-aging pain in patients suffering from painful diabetic neuropathy.Methods: The search covered the Cochrane, MEDLINE,EMBASE and LILACS databases, between January 2000 andAugust 2007. The following information was obtained from eacharticle: criteria for diagnosing diabetic neuropathy, patients’ aver-age age, antidepressant drug received and dose, sample size, dura-tion of the disease and treatment follow-up, outcome measure-ment, evaluation of pain and rescue medication.Results: A combined RR: 1.67 (95% CI 1.38–2.02) was obtained;this result indicated that the antidepressive agents studied wereeffective for controlling pain in diabetic neuropathy. The corre-sponding NNT for Duloxetine was established, according to ourinterests; NNT = 6 (95% CI 5–8) for achieving greater than 50%analgesia in patients suffering from painful diabetic neuropathy.Conclusion: Antidepressive agents are frequently employed in thespecific case of diabetic neuropathy; the combined result of thismeta-analysis has demonstrated their analgesic benefit.
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    Antinuclear autoantibodies: Discordance among four different assays
    (2020) Pacheco Nieva, Yovana; Monsalve Carmona, Diana Marcela; Acosta Ampudia, Yeny Yasbleidy; Rojas, Cilia; Anaya, Juan-Manuel; Ramírez Santana, Heily Carolina
    Detection of antinuclear antibodies (ANAs) is of paramount importance for diagnosis and assessment of autoimmune diseases (ADs), but may vary depending on the method used. Therefore, we aimed to compare three different line immunoassays (LIAs) for ANAs testing in order to simultaneously evaluate their concordance with the results obtained by a well known and widely used ELISA. Sera from women with established systemic lupus erythematosus
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    Barriers to implementation of Evidence-Based Practice (EBP): a survey of Colombian and Spanish physiotherapists
    (2015-05-01) Girabent-Farrés, M.; Bagur-Calafat, C.; Serra-Llobet, P.; Sánchez-Puccini, M.B.; Domínguez-Sánchez, M.A.; Correa-Bautista, J.E.; Flórez-López, M.E.; Ramírez-Vélez, R.
    In countries such as Australia, Spain, United States, Colombia, and United Kingdom, the use, teaching and evaluation of ‘evidence-based physical therapy’ (EBPT) in clinical practice has been recently included in educational curriculum. As consequence, PT have support the EBPT, proposing a series of initiatives designed to generate, evaluate and disseminate research, and to implement these results in practice. Despite most research has focused on the use of evidence, including a critical review of studies and scientific literature in clinical practice, if it is desiderate that the use of EBP becomes a reality, it is important to examine the numerous perceived barriers to using research in clinical settings, despite the paucity of studies in this topic. This is especially true for professions such as physiotherapy that has a small research base and few resources compared with other professions. Typically, barriers are context-dependent; therefore, the implementation of strategies should be tailored according to the context and the specific barriers identified. The most commonly reported barrier among PT is the limited time, which constrains the identification and interpretation of research evidence, as well as the ability to apply research findings in clinical practice.
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    Budismo Nichiren: origen, esencia, práctica y su presencia en Sudamérica
    (2011) Puig Zhamaganov, Bair Eloyevich
    En el contexto del tema central del congreso –El nuevo Sur. Teorías y práctica de Asia, África y América Latina en el siglo XXI nos parece importante llamar la atención a las prácticas religiosasdelLejanoOrienteenparticularelbudismojaponésdellinaje Nichiren, que ha tenido un gran desarrollo en el mundo y en América Latina. El linaje delllamadobudismodeNichiren,monjebudistajaponésdelsigloXIII,tienesus orígenesideológicosenladoctrinadelaescuelabudistachinaTiantaiparalacualel Sutra del Loto representa la médula de la enseñanza de Buda.Nichiren es consideradoun erudito, hizo un estudio detallado de los sutras, retoma los planteamientos de la escuelaTendai y escribe más de 400 documentos donde expone su visióndelbudismo,queporsucarácterreformistalecuestalapersecuciónyel confinamiento.Sonsusdiscípuloslosquemantuvieronlatenteestanuevadoctrinay práctica.TerminadalaSegundaGuerraMundialseproduceunrenacimientodeesta práctica religiosa y su posterior difusión en Occidente.Esto es así precisamente, porque el budismo de Nichiren, al tener como eje principal el Sutra delLoto, crea en los adeptos laconcienciade queel hombre puedealcanzar sus metas y objetivos aún en las condiciones más adversas. Entre continuadores del legado de Nichiren, la organización que posee el mayor número de seguidores a nivel mundial es la SGI (Soka Gakai Internacional), que en la actualidad moviliza millones de adeptos con un considerable respaldo económico.Esta corriente llega a América Latina con las migraciones de japoneses y con emisarios especialmenteencargados de establecer grupos de practicantesycentros religiosos.La SGI cuenta con representación en la mayoría de los países de América del Sur.
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    Cambios en el periodismo, cambios en la audiencia.
    (2009-01-01) Zúñiga Reyes, Danghelly Giovanna
    La tecnología permite hoy a los ciudadanos participar más activamente en los medios de comunicación. Para examinar la transformación del ciudadano en periodista, veremos si los ciudadanos que participan por distintas vías en dos diarios digitales de Colombia (El Tiempo y El Espectador) definen y dan forma a las noticias o si los periodistas son los únicos árbitros de lo que es de interés periodístico, ciudadano y democrático. Las ventajas que brinda la red para el periodismo son evidentes: la velocidad, la eficiencia de la entrega, la selectividad personal, la disponibilidad en demanda, la posibilidad de tener casi un costolibre, la posibilidad para almacenar el contenido adicional y aceptar a usuarios adicionales (Steiger, 2006) además de la interactividad, la hipertextualidad, la multimedialidad y la asincronidad (Bardoel, 2002). Para analizar la relación usuario-periodista partimos del hecho de que las noticias se han transformado debido a la concentración de los medios informativos en grandes empresas. Para Cohen (2002) esta concentración es el primer plano de la transformación en la práctica del periodismo en línea. Cohen identifica tres aspectos que son relevantes para el periodismo digital y que a su vez permiten identificar las posibles formas de fractura de la muralla que establecen los grandes conglomerados.
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    Capacity Utilization in Electricity Market Behavior: An Experimental Analysis
    (2019) Castañeda, Jaime Andrés; Arango Aramburo, Santiago
    This paper describes a laboratory experiment of electricity markets to study the effect of variable capacity utilization over market dynamics. Previous experiments have left out a potential source of cyclical behavior by assuming full capacity utilization. We run 12 experimental markets of the power generation sector, involving two treatments: a first treatment with fixed (full) capacity utilization where subjects make investment decisions, and a second treatment where subjects make both investment and capacity utilization decisions. Visual inspections, basic statistics and simulation tests run with decision rules estimated from experimental data show that the markets run under full capacity utilization present a cyclical behavior in market development. Conversely, such tests show a noncyclical market development for the markets run under variable capacity utilization, suggesting that varying capacity utilization favors stability rather than a cyclical behavior.
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    Case studies in the application of an effective anticollision risk management standard
    (2010) Poedjono, Benny; Avila, Carlos; Phan Van, Chinh; Isevcan, Erhan; Walker, John; Gonzalez, Luis Felipe; McCulloch, Simon; Juárez, Fernando; Moreno, Victor Hugo
    Economic, regulatory, and technological changes have steadily increased the oil and gas industry's need for an effective approach to assessing and managing the risk of well collisions. We have developed such an approach, which has been used successfully in recent years in a number of major land and offshore drilling projects worldwide. This approach has been adopted as a standard by the major oilfield service company of which we are a part. In this paper, we describe four recent experiences in which this standard has been applied, and discuss the challenges of its implementation and the economic, environmental, and health and safety benefits it provides. Based on its proven success, we make a case for using this approach as a foundation for development and adoption of an industry-wide anticollision and risk management standard.
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    Child labor and health: exploratory study from a public market in Valencia, Venezuela
    (2010-07-17) Rojas Quintana, Manuel Eduardo; Vegas, Z.; Briceño Ayala, Leonardo; Rodriguez, L.
    This study was done to determine life conditions, work practices, health effects and associated occupational risks factors in working children from a public market, in Valencia, Venezuela. A questionnaire was administered including demographic and exposure variables with special emphasis on occupational risks. A descriptive analysis was done with the data. Forty four (44) children (37 boys and 7 girls) were selected, mean age 14.4 ± 2.3 years old. The average workday was 9.25 ± 3.2 h/day. The most frequent activity was provisions and fruits retail sale (43.2%).
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    Clinical Course of Asthma of Children Treatedwith Omalizumab: Multicenter Study Colombia
    (2016-04) Morales Munera,Olga Lucía; Pedraza,Angela María; Niño Serna,Laura Fernanda
    Objective: To describe the clinical characteristics of pediatric patients aged6 to 17 years diagnosed with moderate to severe allergic asthma undergoingtreatment with omalizumab (OMB) from January 2007 to February 2014 in6 cities in Colombia. Methods: This retrospective, longitudinal cohort studyincluded 63 children and adolescents. Evaluated outcomes includedsymptoms control, exacerbations frequency, decreased use of asthmacontrol drugs and presence of adverse events before starting treatment andafter 4 and 12 months of OMB use. Results: after 4 and 12 months oftreatment 89% and 96.6% of children under 12 years of age (p ¼ 0.0015) and78% and 91.6% of children over 12 years of age (p ¼ 0.0145) had goodsymptom control, respectively. Furthermore, after 12 months, the number ofexacerbations decreased to 2 (p ¼ 0.00), the frequency of beta2 rescueinhaler use decreased to 0.37 days (p ¼ 0.00), and the use of controller drugsdecreased in 73% of patients, including decreased use of inhaledcorticosteroids in 62%. Only one severe adverse event was reported inone patient. Conclusion: OMB is an effective drug for the clinical control ofmoderate and severe allergic asthma. It reduces asthma symptoms andexacerbations and exhibits good tolerance and few severe adverse event
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    ¿Cómo influye la edad en el inicio en las enfermedades reumáticas autoinmunes?
    (2013-10) Amaya-Amaya,Jenny; Sarmiento-Monroy, Juan-Camilo; Molano González, Nicolás; Rodríguez Jiménez, Mónica María del Pilar; Anaya, Juan-Manuel
    La edad al inicio de la enfermedad (AOD) se refiere al período de tiempo en el que un paciente experimenta el primer signo (s) y síntoma (s). La AOD varía entre las enfermedades autoinmunes (EA) y se ha relacionado con el pronóstico en algunas de ellas. Factores genéticos, epigenéticos y ambientales pueden influir en la AOD. El objetivo fue evaluar la influencia de la AOD en el curso clínico y el resultado en pacientes adultos (> 17 años) con enfermedades reumáticas autoinmunes, a saber, artritis reumatoide (AR), lupus eritematoso sistémico (LES) y síndrome de Sjögren (SS).
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    Complex modular architecture around a simple toolkit of wing pattern genes.
    (2017) Van Belleghem, Steven M; Rastas, Pasi; Papanicolaou, Alexie; Martin, Simon H; Arias, Carlos Francisco; Supple, Megan A; Hanly, Joseph J; Mallet, James; Lewis, James J; Hines, Heather M; Ruiz, Mayte; Salazar, Camilo; Linares, Mauricio; Moreira, Gilson R P; Jiggins, Chris D; Counterman, Brian A; McMillan, W Owen; Papa, Riccardo
    Identifying the genomic changes that control morphological variation and understanding how they generate diversity is a major goal of evolutionary biology. In Heliconius butterflies, a small number of genes control the development of diverse wing colour patterns. Here, we used full-genome sequencing of individuals across the Heliconius erato radiation and closely related species to characterize genomic variation associated with wing pattern diversity. We show that variation around colour pattern genes is highly modular, with narrow genomic intervals associated with specific differences in colour and pattern. This modular architecture explains the diversity of colour patterns and provides a flexible mechanism for rapid morphological diversification.
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    Complex modular architecture around a simple toolkit of wing pattern genes.
    (2017) Van Belleghem, Steven M; Rastas, Pasi; Papanicolaou, Alexie; Martin, Simon H; Arias, Carlos Francisco; Supple, Megan A; Hanly, Joseph J; Mallet, James; Lewis, James J; Hines, Heather M; Ruiz, Mayte; Salazar, Camilo; Linares, Mauricio; Moreira, Gilson R P; Jiggins, Chris D; Counterman, Brian A; McMillan, W Owen; Papa, Riccardo
    Identifying the genomic changes that control morphological variation and understanding how they generate diversity is a major goal of evolutionary biology. In Heliconius butterflies, a small number of genes control the development of diverse wing color patterns. Here, we used full genome sequencing of individuals across the Heliconius erato radiation and closely related species to characterize genomic variation associated with wing pattern diversity. We show that variation around color pattern genes is highly modular, with narrow genomic intervals associated with specific differences in color and pattern. This modular architecture explains the diversity of color patterns and provides a flexible mechanism for rapid morphological diversification.
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    Computational Neuroeconomic Decision-Making Trajectories as Predictors of Clinical Outcomes for Opioid Use Disorde
    (2019-12) Lopez-Guzman,Silvia
    los enfoques neuroeconómicos ofrecen un marco prometedor para el modelado algorítmico de la toma de decisiones alterada en la adicción. Concluimos que la dinámica en el tratamiento de estos parámetros neuroeconómicos puede contribuir, junto con otros factores demográficos, de personalidad y de comorbilidad psiquiátrica, a la construcción de un fenotipo de recaída que podría ayudar en la selección de intervención dirigida para la atención individualizada.
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    Cuckoo + ML
    (2018-01-01) Díaz López, Daniel Orlando; Useche, David Esteban; Sepúlveda, Daniela
    Cuckoo Sandbox isan open source sandbox that automates the task of analyzing any malicious file.Cuckoo allows analysis of samples and urls. Itbrings scores and signatures that can be useful to suspect about the sample or url given. Sandboxing basically means having test environments. (Isolated environment)A Sandbox is useful in environments with one or more simultaneously operative systems.
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    Cutaneous involvement in systemic lupus erythematosus. A latent trait analysis
    (2013-03-05) Pérez Fernández, L; Amaya-Amaya J.; Molano González, Nicolás; Mantilla, RD; Rojas Villarraga, A; Anaya, Juan-Manuel
    Cutaneous involvement is one of the most frequent manifestations of systemic lupus erythematosus (SLE); however ethnicity may influence its prevalence and clinical expression. We aimed to evaluate its prevalence and associated factors in a non-Caucasian population.
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    Data Science Applied in Cybersecurity
    (2017-01-01) Díaz López, Daniel Orlando; Blanco Uribe,María Alejandra; Cerón Sánchez,Edwin Alexánder; Gómez Solano,Nicolás Gómez
    Entidades del estado deben cumplir con cierta normativa, OSSIM Permite Descubrir activos – NMAP, Evaluar vulnerabilidades (VA) – OpenVAS, Realizar detección de intrusos (NIDS/HIDS) – OSSEC y Suricata, Monitoreo de integridad de archivos (FIM) –OSSEC, SIEM – OSSIM, Open Source Security Information Management, Licencia GNU/GPL, Correlación de eventos, OPT – Open Threat Exchange.
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    Deepweb (TOR, honeypot)
    (2018-01-01) Díaz López, Daniel Orlando; Herrera Velásquez,Juan Camilo; Meneses Pineda,Carol Johana
    OSSEC y Suricata, Monitoreo de integridad de archivos (FIM) –OSSEC, SIEM – OSSIM, Open Source Security Information Management, Licencia GNU/GPL, Correlación de eventos, OPT – Open Threat Exchange.
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    Acceso Abierto
    Desafíos de la ciencia abierta
    (2018) Lisowska Navarro, Malgorzata; VIII Conferencia BIREDIAL – ISTEC
    Ciencia abierta, es un concepto dinámico y en constante evolución, se considera un medio y no un fin. La clave para hacer realidad la ciencia abierta será asegurar que el contrato social entre los científicos se fortalezca y no se debilite. Los gobiernos y las instituciones públicas de investigación deben garantizar que las políticas científicas abiertas, permitan a los científicos seguir compitiendo y sean reconocidos por sus contribuciones y el compartir el acceso a datos y resultados científicos. La ciencia abierta es más que el acceso abierto a publicaciones o datos; Incluye muchos aspectos y etapas de los procesos de investigación. Es un concepto más amplio que también incluye la interoperabilidad de la infraestructura científica y las metodologías de investigación abiertas y compartidas (como las aplicaciones abiertas y el código informático). y herramientas fáciles de usar que permiten, por ejemplo, minería de texto y datos. Necesita un esfuerzo mancomunado de todos los actores involucrados • Además de los requisitos obligatorios, las agencias de financiamiento pueden promover la ciencia abierta a través del apoyo financiero para cubrir los cargos o costos de publicación de acceso abierto asociados con la publicación de datos y otro material de investigación. Las políticas para promover datos abiertos son menos maduras que aquellas para promover el acceso abierto a publicaciones científicas. Los conjuntos de datos no se identifican y definen tan fácilmente como los artículos de investigación académica. La diversidad de datos científicos y las diferentes tradiciones y normas en su tratamiento también son cuestiones difíciles. Las políticas científicas abiertas deben basarse en principios pero adaptarse a las realidades locales y requieren una diversidad de enfoques. (patentes, comercialización, privacidad de datos). Los marcos legales que son amigables con la ciencia abierta, son un medio adicional para promover la ciencia abierta. (Alemania, Reino Unido)
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    Efecto de los tocotrienoles naturales de la dieta sobre el perfil lipídico y la capacidad oxidativa de las LDL en modelo animal y en adultos humanos
    (2019-07) Cortés L.Y.; Monterrey P.; Corredor C.
    Los tocotrienoles (T3E), además de ser antioxi- dantes presentan efecto hipocolesterolémico. En la década de los 80’ s Qureshi demostró que el efecto hipocolesterolémico de la cebada ocurría a nivel de la síntesis endógena de coleste- rol (1). Posteriormente, Goldstein y Correll, describieron el me- canismo por el que los T3E de la cebada cumplían este papel. La cadena lateral de los T3E induce la enzima prenil-fosfato- fosfatasa produciendo un incremento celular del farnesol, el cual a su vez regula la actividad de la enzima HMG CoA reduc- tasa (2-3). Posteriormente, Theriault y Col. demostraron que el T3E podía reducir los niveles de apoB en el plasma en un 24% aun cuando su síntesis se aumentaba en un 60%, concluyen- do que los T3E al producir una disminución en la disponibili- dad de colesterol, previenen la interacción colesterol-apoB na- ciente e inhiben la síntesis y translocación de la apoB a través del retículo endoplasmático (RE), lo que se traduciría en un aumento en su degradación intracelular y la inhabilidad para sintetizar VLDLc (4). Finalmente, Theriault en 2002, demostró que los T3E reducen la expresión de moléculas de adhesión en el endotelio (5).
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    Effect of a stretching program on the autonomic modulation in hemodialysis patients: pilot study
    (2009-05) Soler, Alejandro; Abaunza, Catalina; Zapata, Marcela; Povea, Camilo
    PURPOSE: To determine the effect of a stretching program over the autonomic modulation in chronic renal patients on hemodialysis. METHODS: An intradialysis exploratory descriptive pilot study was performed executing stretching exercises for one month every other day. The sample consisted of 3 men (53+/-13,2 yrs) and 4 women (26+/-5,7 yrs) who signed an informed consent. They were evaluated by means of a heart rate variability registry, a challenge of the autonomic nervous system, and stretching tests. The registry was divided into three phases with a 21 minute duration: an initial one in supine position, an orthostatic challenge, and a final one in supine position again. At the end of the month, the patients were re-evaluated. RESULTS: The standard deviation of the RR intervals showed the same tendency but in an opposite direction in women (29,9 +/-11,1 ms before vs 23,7 +/-12,6 ms after), with respect to men (15,3 +/-6,0 ms before vs 22,5 +/-5,0 ms after). The same result occurred with the total spectral power in women (2764,8 +/-1108,5 ms2/Hz before vs 1574,2 +/-1123,8 ms2/Hz after) with respect to men (1162 +/-437,4 ms2/Hz before vs 1646 +/-220,2 ms2/Hz after). The 30:15 index, which was abnormal in all at the beginning of the intervention (0,9+/-0,03), showed an increment in all patients and was normalized in one young female (1,05). The net differences of the high frequency index (-5,9+/-7,9 ms2/Hz before vs 3,9+/-8,9 ms2/Hz after) in the entire sample could indicate some degree of neurovegetative modification. CONCLUSION: This study concludes the existence of an autonomic dysfunction in chronic renal patients confirmed by the differences in the 30:15 index, and the tendency towards a modification in parasympathetic reactivity by means of a stretching program.
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    Effects of health professional supervised multimodal exercise interventions on cancer-related fatigue: systematic review and meta-analysis of randomized controlled trials
    (2015-05-01) Meneses-Echávez, J.; González-Jiménez; Ramírez-Vélez, R.; Correa-Bautista, J.E.
    Cancer-related fatigue (CRF) is the most common and distressing symptom in breast cancer survivors. Approximately 40% to 80% of cancer patients undergoing active treatment suffer from CRF. Exercise improves overall quality of life and CRF; however, the specific effects of the training modalities are not well understood. Purpose: This study aimed to determine the effects of health professional supervised multimodal exercise interventions on cancer-related fatigue through a systematic review and meta-analysis.
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    Establishing normative reference values for the 20-meter shuttle-run test among schoolchildren in bogota, Colombia: the fuprecol study 2765 Board #288 June 3, 930 AM - 1100 AM
    (2016-05) Palacios-López, Adalberto; González-Ruíz, Katherine; Benavides Rodríguez, Lorena; Camelo-Prieto, Diana Lorena; Correa Bautista, Jorge Enrique; Ramírez-Vélez, Robinson
    PURPOSE: There is increasing evidence that cardiorespiratory fitness (CRF) is an important health marker in youth. CRF values for children and adolescents from different countries have been published, but there is a scarcity of reference values for Latin American children and adolescents using recommended CRF estimation field tests such as the 20-m shuttle-run test as evidence of CRF in Colombian schoolchildren. In addition to presenting normative reference values, we also aim to establish the proportion of subjects whose aerobic capacity is indicative of future cardiovascular risk. METHODS: A total of 7244 children and adolescents (55.7% girls, with a sample age range of 9-17.9 years) completed the 20 m shuttle-run test (median age, in years = 12.8 (SD 2.3); 25th-75th percentile: 11.0-15.0. We expressed performance as the number of shuttle-runs completed and the estimated peak oxygen consumption (VO2peak). Smoothed percentile curves and tables for the 3rd, 10th, 25th, 50th, 75th, 90th and 97th percentiles were calculated using Cole’s LMS method. In addition, we calculated the number of participants who fell below proposed cut-offs for low CRF based on either completed shuttle-runs or by VO2peak. RESULTS: In general CRF levels increased with age. Among boys CRF, where higher between the ages of 14 and 17 and in girls between the ages of 12 and 14, but this increase was more modest. Shuttles and VO2peak were higher in boys than in girls in all age-specific groups. The proportion of subjects with a CRF indicative of future cardiovascular risk was 11.5%. By sex, 9.65% of boys and 13.1% of girls (X2 p < .001) displayed an unhealthy aerobic capacity in this study. CONCLUSIONS: Our results provide reference standards for sex- and age-specific twenty- meter shuttle-run test scores and VO2peak values in Colombian schoolchildren aged 9-17.9 years for the first time. These values are particularly important in public health and educational settings, and future research should establish a cut-off value for test performance that can predict present or future ill health.
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    ¿Estamos preparados para trabajar en red? Interoperabilidad: desafíos para la región latinoamericana
    (2014) Lisowska Navarro, Malgorzata; Garrido Arenas, Humbert Alexander; XX Asamblea General de ISTEC
    La presentación remarca la importancia de unificar, en la medida de lo posible, los estándares, directrices y protocolos de los repositorios para que la interoperabilidad sea un hecho.
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    Factors associated with lupus nephritis in a highly admixed population
    (2013-03-05) Pérez Fernández, JL; Amaya-Amaya J.; Molano González, Nicolás; Mantilla, RD; Rojas Villarraga, A; Anaya, Juan-Manuel
    Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematous (SLE). Multiple clinical and serological risk and protective factors for LN have been identified in Caucasians. The aim of this study was to examine associated factors for LN in a new cohort of Latin American patients.
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    FRI0055 The influence of cigarette smoking on disease activity and joint erosions in rheumatoid arthritis: a systematic review and meta-analysis.
    (2013-06) La Hoz, J. Castellanos-De; Amaya-Amaya, J.; Molano González, Nicolás; Gutiérrez-Infante, F.; Anaya, Juan-Manuel; Rojas-Villarraga, A.
    There is a clear causal relationship between tobacco smoking and rheumatoid arthritis (RA), supported by observational studies and systematic reviews ; however, the effect of smoking on disease activity and the development of joint surface erosions has not been clearly established. Current data are conflicting, with some studies reporting an increased activity and progression of erosions and others showing an opposite relationship.
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    FRI0409 Smoking and SjÖGren's Syndrome Are Predictors of Autoimmune Thyroid Disease in Systemic Lupus Erythematosus
    (2014-06) Franco, J.-S.; Amaya-Amaya, J.; Molano González, Nicolás; Rodríguez Jiménez, Mónica María del Pilar; Acosta Ampudia, Yeny Yasbleidy; Mantilla, R.D.; Rojas-Villarraga, A.; Anaya, Juan-Manuel
    Background Autoimmune thyroid disease (AITD) has been described as the most prevalent autoimmune disease (AD) as well as being associated with other organ-specific and non-organ specific ADs.
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    FRI0513 Does non - erosive rheumatoid arthritis exist ?
    (2013-06) Amaya-Amaya, J.; Calvo-Páramo, E.; Calderon-Páez, A.; Torralvo-Morato, G.; Calixto, O. J.; Mantilla, R. D.; Anaya, Juan-Manuel; Rojas-Villarraga, A.
    Background Erosions are the hallmark of rheumatoid arthritis (RA). Although most of erosions may occur within 2 years of onset of the disease, their progression does not correlate with the duration of RA. Moreover, information about non-erosive RA is ambiguous. Objectives To evaluate the prevalence and characteristics of non-erosive RA. Methods Since no agreement about the time-lag interval for erosions appearance in RA exists, and there is no universally accepted definition about it, a zero score in hands and feet X-ray at 5 years of RA duration (by SvHD) was arbitrary considered as cut-off. Therefore, patients meeting these criteria were searched in a large cohort of RA patients (ACR, 1987). Metacarpophalangeal and metatarsophalangeal joints as well as wrist ultrasound (US) imaging (by OMERACT), and computed tomography (CT) were performed to confirm non-erosive RA. Spearman correlation coefficient, kappa analysis and Kendall´s W test were used to analyze data. Results Out of a total of 800 RA patients, 38 met inclusion criteria (4.75%). Most of them were women (76.3%). The median (IQR) of the age and duration of the disease were 52 (13) and 10 (8) years, respectively. Rheumatoid factor (RF) and anti-CCP antibodies were positive in 86.8% and 55.3%, respectively. Non-erosive RA was confirmed by the three methods in only 7 patients. There was no concordance between the three methods. For this sample, the sensitivity and specificity were 70% and 52% for US, and 58% and 57% for CT, respectively. Non-erosive RA was positively although weakly correlated with improved functional class according to the HAQ (r=0.32, p=0.045) and ANA positivity (r=0.43, p=0.030), and negatively correlated with activity of the disease (by RAPID3, r= -0.32, p=0.05), the use of biological therapy (r= -0.31, p=0.05) and RF (r= -0.36, p=0.042). Conclusions Non-erosive RA is rare (0.87%). A good functional class, ANA positivity, RAPID3 score, the use of biological therapy and RF influence the absence of erosions in long-standing RA (i.e., 5 years). Since there is a high variability and a lack of concordance exists among the imagining techniques, a consensus and unified definition about non-erosive RA are warranted.
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    Functional magnetic resonance in medicine students with and without partial sleep restriction
    (2013-09) Bermudez S.; Hernandez J.T.; Perez I.; Morillo A.J.; Bernal B.; Santiago G.; Torres S.; Ocampo A.; Ibáñez Pinilla, Milcíades; Rascovsky S.; Sanz, A.; Reyes, P.
    OBJECTIVE To describe the effects of partial sleep restriction (PSR) in the brain regions involved in cognitive inhibition processes, motor function and phonological fluency using functional Magnetic Resonance Imaging (fMRI). METHOD A sample of 12 graduate medicine students were subject to a follow-up of the number of hours of habitual sleep and underwent fMRI studies evaluating 4 paradigms before and after the PSR : Stroop (in standard and modified versions), right hand movement and verbal fluency. The PSR was equivalent to one night-shift, with at least 45 % sleep restriction with respect to the habitual sleep pattern during the previous week. The d2 attention test was done before and after the PSR to evaluate attention. RESULTS The d2 attention test did not show any significant differences between the habitual sleep condition and the PSR. Significant differences were found in BOLD activity for the motor function (P<0.05). Changes in BOLD activity were not observed for the Stroop nor verbal fluency paradigms.
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    Genetic and epigenetic effects in a population of underground miners with coal workers Pneumoconiosis
    (2019-09-19) Narváez, DM; Varona Uribe, Marcela Eugenia; Palma, RM; Briceño Ayala, Leonardo; Hernández-Vargas, H; Groot, H
    Coal Workers Pneumoconiosis (CWP) is a respiratory occupational disease caused by chronic exposure to breathable mine dust which is characterized by an inflammatory reaction and a subsequent progressive massive fibrosis. The disease is irreversible and incurable; therefore, early diagnosis or prediction may become useful to control CWP. Oxidative stress is known to play an important rolein pathogenesis.Oxidative DNA damageis repaired by the Base Excision Repair (BER) pathway; therefore,genetic variations in BER pathway enzymes may confer differential risk in CWP. On the other hand, as has been shown for other environmental pollutants DNA methylation may represent an interface between exposure and disease. Biomarkers of exposure, effect and susceptibility were assessed in order to evaluate oxidative stress and methylation changes associated with the disease and the influence ofOGG1and XRCC1polymorphisms in CWP development. A group of 474 underground coal miners were selected to participate in this cross-sectional study. This population was subdivided into two groups of healthy and CWP miners. We show that underground miners who develop pneumoconiosis have a higher level of the oxidative stress marker 8-OHdG in white blood cells, and that this oxidative DNA damage was associated withXRCC1194Trp allele. In addition, leukocytes from CWP cases are differentially methylated at two immune-related loci when compared with control miners, as assessed by bisulfite pyrosequencing. Information regarding genetic, epigenetic and exposure conditions will contribute to the better understanding of disease aetiology in a population.
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    Genetic-molecular study of the egfr/ pi3k/akt pathway in high and low grade gliomas
    (2010-11) Erira, Alveiro; Penagos, Jose; Zubieta, Camilo; Velandia Hurtado, Fernando Alfredo; Arboleda, Humberto; Arboleda Gonzalo
    Gliomas account for 70% of all central nervous system (CNS) tumors and are classified according to the WHO in low (I and II) or high (III and IV or glioblastoma multiforme, GBM) grade malignancies. The survival of patients with a high grade is less than 2 years. The EGFR/PI3K/AKT pathway promotes cellular survival, inhibits apoptosis and differentiation. This pathway is regulated by phosphatase homologous of tensin (PTEN). In gliomas, amplification of EGFR and PI3K has been reported, as well as mutations in PI3KCA and PTEN, which are associated with permanent activation of this signaling pathway and with decreased expression of pro-apoptotic genes such as Bax and increased expression of anti-apoptotic genes such as Bcl2. We obtained 30 samples of gliomas with high and low grade. Amplification was assessed by real-time PCR with TaqMan probes for the EGFR, PI3K and AKT genes. Mutations in PI3KCA (9 and 20 exons) and PTEN (5 and 6 exons) were determined by direct sequencing from DNA using specific primers for each exon. The results of each sample were analyzed in 50 e30 and 30 e50 orientations using the program FINCH TV. Subsequent alignment was performed for each sample with the human reference sequence (obtained from Gene Bank) using the GENE RUNNER program. To assess the expression levels of the PI3K, AKT, Bax, and Bcl2 genes, cDNA obtained by reverse transcription was amplified by real-time PCR with SYBR Green using specific primers for each gene. The results were analyzed by calculating the CT. We did not find any high level EGFR amplifications. Only one grade IV sample showed an increase in gene dosage (2.8 times). PI3K was found amplified in 50% of grade I and II (0.4 times) and in 45% of grade III and IV (between 0.5 and 0.9 times). However, in 18% of the grade IV samples, the increase was greater than 1. AKT was not found amplified in the samples analyzed. Also, no mutations were found in PI3K and PTEN. In low-grade gliomas we found an increase (O1 time) in PI3K (62%), AKT (12.5%), Bcl2 (50%), and Bax (25%) gene expression. In highgrade tumors over-expression of PI3K (50%), AKT, Bcl2, and Bax (all 32%) was found.