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- ÍtemSolo MetadatosAB0403 Cigarette smoking and coffee consumption independently influence the risk of developing cardiovascular disease in systemic lupus erythematosus(2013-06) Amaya-Amaya, J.; Pérez-Fernández, J. L.; Molano González, Nicolás; Mantilla, R. D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Cardiovascular disease (CVD) is a major cause of morbidity and mortality in patients with systemic lupus erythematosus (SLE), a 50-fold than general population. Traditional risk factors, such as, cigarette smoking and dyslipidemia, are known but they cannot fully account for the increased risk. Instead, non-traditional risk factors, related to disease are also contributing. Varied results have been reported on the association between coffee drinking and CVD in the general population, with controversial results. Coffee consumption has not been evaluated systematically in SLE patients with CVD.
- ÍtemSolo MetadatosAB0405 Factors associated with lupus nephritis in a highly admixed population(2013-06) Pérez-Fernández, J. L.; Amaya-Amaya, J.; Molano González, Nicolás; Mantilla, R.-D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Lupus nephritis (LN) is one of the most serious complications of systemic lupus erythematous (SLE). Multiple clinical and serological risk and protective factors for LN have been identified in Caucasians.
- ÍtemSolo MetadatosAB0421 Cutaneous involvement in systemic lupus erythematosus.a latenttraitanalysis(2013-06) Molano González, Nicolás; Pérez-Fernández, J. L.; Amaya-Amaya, J.; Mantilla, R. D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Cutaneous involvement is one of the most frequent manifestations of systemic lupus erythematosus (SLE); however ethnicity may influence its prevalence and clinical expression.
- ÍtemSolo MetadatosAntinuclear autoantibodies: Discordance among four different assays(2020) Pacheco Nieva, Yovana; Monsalve Carmona, Diana Marcela; Acosta Ampudia, Yeny Yasbleidy; Rojas, Cilia; Anaya, Juan-Manuel; Ramírez Santana, Heily CarolinaDetection of antinuclear antibodies (ANAs) is of paramount importance for diagnosis and assessment of autoimmune diseases (ADs), but may vary depending on the method used. Therefore, we aimed to compare three different line immunoassays (LIAs) for ANAs testing in order to simultaneously evaluate their concordance with the results obtained by a well known and widely used ELISA. Sera from women with established systemic lupus erythematosus
- ÍtemSolo Metadatos¿Cómo influye la edad en el inicio en las enfermedades reumáticas autoinmunes?(2013-10) Amaya-Amaya,Jenny; Sarmiento-Monroy, Juan-Camilo; Molano González, Nicolás; Rodríguez Jiménez, Mónica María del Pilar; Anaya, Juan-ManuelLa edad al inicio de la enfermedad (AOD) se refiere al período de tiempo en el que un paciente experimenta el primer signo (s) y síntoma (s). La AOD varía entre las enfermedades autoinmunes (EA) y se ha relacionado con el pronóstico en algunas de ellas. Factores genéticos, epigenéticos y ambientales pueden influir en la AOD. El objetivo fue evaluar la influencia de la AOD en el curso clínico y el resultado en pacientes adultos (> 17 años) con enfermedades reumáticas autoinmunes, a saber, artritis reumatoide (AR), lupus eritematoso sistémico (LES) y síndrome de Sjögren (SS).
- ÍtemSolo MetadatosCutaneous involvement in systemic lupus erythematosus. A latent trait analysis(2013-03-05) Pérez Fernández, L; Amaya-Amaya J.; Molano González, Nicolás; Mantilla, RD; Rojas Villarraga, A; Anaya, Juan-ManuelCutaneous involvement is one of the most frequent manifestations of systemic lupus erythematosus (SLE); however ethnicity may influence its prevalence and clinical expression. We aimed to evaluate its prevalence and associated factors in a non-Caucasian population.
- ÍtemSolo MetadatosFactors associated with lupus nephritis in a highly admixed population(2013-03-05) Pérez Fernández, JL; Amaya-Amaya J.; Molano González, Nicolás; Mantilla, RD; Rojas Villarraga, A; Anaya, Juan-ManuelLupus nephritis (LN) is one of the most serious complications of systemic lupus erythematous (SLE). Multiple clinical and serological risk and protective factors for LN have been identified in Caucasians. The aim of this study was to examine associated factors for LN in a new cohort of Latin American patients.
- ÍtemSolo MetadatosFRI0055 The influence of cigarette smoking on disease activity and joint erosions in rheumatoid arthritis: a systematic review and meta-analysis.(2013-06) La Hoz, J. Castellanos-De; Amaya-Amaya, J.; Molano González, Nicolás; Gutiérrez-Infante, F.; Anaya, Juan-Manuel; Rojas-Villarraga, A.There is a clear causal relationship between tobacco smoking and rheumatoid arthritis (RA), supported by observational studies and systematic reviews ; however, the effect of smoking on disease activity and the development of joint surface erosions has not been clearly established. Current data are conflicting, with some studies reporting an increased activity and progression of erosions and others showing an opposite relationship.
- ÍtemSolo MetadatosFRI0409 Smoking and SjÖGren's Syndrome Are Predictors of Autoimmune Thyroid Disease in Systemic Lupus Erythematosus(2014-06) Franco, J.-S.; Amaya-Amaya, J.; Molano González, Nicolás; Rodríguez Jiménez, Mónica María del Pilar; Acosta Ampudia, Yeny Yasbleidy; Mantilla, R.D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Autoimmune thyroid disease (AITD) has been described as the most prevalent autoimmune disease (AD) as well as being associated with other organ-specific and non-organ specific ADs.
- ÍtemSolo MetadatosFRI0513 Does non - erosive rheumatoid arthritis exist ?(2013-06) Amaya-Amaya, J.; Calvo-Páramo, E.; Calderon-Páez, A.; Torralvo-Morato, G.; Calixto, O. J.; Mantilla, R. D.; Anaya, Juan-Manuel; Rojas-Villarraga, A.Background Erosions are the hallmark of rheumatoid arthritis (RA). Although most of erosions may occur within 2 years of onset of the disease, their progression does not correlate with the duration of RA. Moreover, information about non-erosive RA is ambiguous. Objectives To evaluate the prevalence and characteristics of non-erosive RA. Methods Since no agreement about the time-lag interval for erosions appearance in RA exists, and there is no universally accepted definition about it, a zero score in hands and feet X-ray at 5 years of RA duration (by SvHD) was arbitrary considered as cut-off. Therefore, patients meeting these criteria were searched in a large cohort of RA patients (ACR, 1987). Metacarpophalangeal and metatarsophalangeal joints as well as wrist ultrasound (US) imaging (by OMERACT), and computed tomography (CT) were performed to confirm non-erosive RA. Spearman correlation coefficient, kappa analysis and Kendall´s W test were used to analyze data. Results Out of a total of 800 RA patients, 38 met inclusion criteria (4.75%). Most of them were women (76.3%). The median (IQR) of the age and duration of the disease were 52 (13) and 10 (8) years, respectively. Rheumatoid factor (RF) and anti-CCP antibodies were positive in 86.8% and 55.3%, respectively. Non-erosive RA was confirmed by the three methods in only 7 patients. There was no concordance between the three methods. For this sample, the sensitivity and specificity were 70% and 52% for US, and 58% and 57% for CT, respectively. Non-erosive RA was positively although weakly correlated with improved functional class according to the HAQ (r=0.32, p=0.045) and ANA positivity (r=0.43, p=0.030), and negatively correlated with activity of the disease (by RAPID3, r= -0.32, p=0.05), the use of biological therapy (r= -0.31, p=0.05) and RF (r= -0.36, p=0.042). Conclusions Non-erosive RA is rare (0.87%). A good functional class, ANA positivity, RAPID3 score, the use of biological therapy and RF influence the absence of erosions in long-standing RA (i.e., 5 years). Since there is a high variability and a lack of concordance exists among the imagining techniques, a consensus and unified definition about non-erosive RA are warranted.
- ÍtemSolo MetadatosOP0020 Identification of Multiple Sjögren’s Syndrome Susceptibility Loci(2013-06) Lessard, C. J.; Li, H.; Ice, J. A.; Adrianto, I.; Jonsson, R.; Illei, G. G.; Rischmueller, M.; Nordmark, G.; Mariette, X.; Miceli-Richard, C.; Herlenius, M. Wahren; Witte, T.; Brennan, M.; Omdal, R.; Gaffney, P. M.; Lessard, J. A.; Rönnblom, L.; Ng, W.-F.; Rhodus, N.; Segal, B.; Scofield, R. H.; James, J. A.; Anaya, Juan-Manuel; Montgomery, C. G.; Harley, J. B.; Sivils, K. MoserBackground Sjögren’s syndrome (SS) is a common, clinically heterogeneous autoimmune disease characterized by exocrine gland dysfunction that involves both innate and adaptive immune responses. A complex genetic architecture has been hypothesized; however, genetic studies to date have been limited to candidate gene approaches.
- ÍtemSolo MetadatosSAT0015 Novel and rare mutations linked to polyautoimmunity(2016-06) Johar, A.; Sarmiento-Monroy, J.C.; Rojas-Villarraga, A.; Silva-Lara, M.F.; Patel, H.R.; Mantilla, R.D.; Mastronardi, C.; Arcos-Burgos, M.; Anaya, Juan-ManuelBackground Polyautoimmunity (i.e., the presence of two or more autoimmune diseases in a single patient) and familial autoimmunity (i.e., diverse autoimmune diseases in a nuclear family) represent extreme phenotypes ideal for identifying major genomic variants contributing to autoimmunity (1–3). Whole Exome Sequencing (WES) and linkage analysis are well suited for this purpose due to its strong resolution upon familial segregation patterns of functional protein coding and splice variants
- ÍtemSolo MetadatosSAT0055 Exploration of risk factors for rheumatoid arthritis using advance recursive partitioning approach(2014-06) Molano González, Nicolás; Arcos-Burgos, M.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground A major challenge for rheumatoid arthritis (RA) research is the detection of subjects at risk. The tradeoff between complexity and interpretability is a key issue in the application of predictive models. Advance recursive partitioning (tree-based) approach (ARPA) is widely used in predictive analyses as it accounts for non-linear effects, offers fast solutions for hidden complex substructure and provides truly non-biased, statistically significant analyses of high dimensional, seemingly unrelated data.
- ÍtemSolo MetadatosSAT0306 How does cigarette smoking affect Sjögren's syndrome?(2016-06) Sarmiento-Monroy, J.C.; Molano González, Nicolás; Rodríguez Jiménez, Mónica María del Pilar; Mantilla, R.D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Cigarette smoking has been found to play a pathogenic role in several autoimmune diseases. However, data about its influence on Sjögren's syndrome (SS) is scarce
- ÍtemSolo MetadatosSAT0319 Severity in systemic lupus erythematosus patients: A latent trait analysis(2016-06) Molano González, Nicolás; Sarmiento-Monroy, J.C.; Rodríguez Jiménez, Mónica María del Pilar; Mantilla, R.D.; Rojas-Villarraga, A.; Anaya, Juan-ManuelBackground Systemic Lupus Erythematosus (SLE) is a complex disease which can potentially involve any organ and, therefore, has a wide range of clinical manifestations (i.e., subphenotypes)
- ÍtemSolo MetadatosSAT0463 Polyautoimmunity and clustering of autoimmune diseases(2013-06) Rojas-Villarraga, A.; Amaya-Amaya, J.; Lopez-Kleine, L.; Guarin-Parra, M.R.; Rodriguez-Rodriguez, A.; Mantilla, R.D.; Anaya, Juan-ManuelTo identify polyautoimmunity and to search for a grouping pattern of autoimmune diseases (ADs)
- ÍtemSolo MetadatosSP0089 Trends in the treatment of rheumatoid arthritis in Latin America(2014-06) Anaya, Juan-ManuelLatin America and the Caribbean (LAC) is a rapidly growing region with almost 600 million inhabitants composed of Mexico, Central and South America, and the islands of the Caribbean. The population of LAC is one of the most diverse in the world. There is an increased prevalence of chronic diseases in LAC which has been attributed to diverse causes, including ancestry, socioeconomic status, the ageing of the population, and lifestyle factors such as smoking, physical inactivity, and excessive alcohol intake
- ÍtemSolo MetadatosSP0228 Polyautoimmunity. diagnosis and significance(2015-06) Anaya, Juan-ManuelAutoimmune diseases (ADs) are chronic and heterogeneous conditions that affect specific target organs or multiple organ systems. They are caused by the interactions over time between hereditary and environmental factors leading to a breakdown in immune tolerance and the ensuing tissue damage. The fact that these disorders share several clinical signs and symptoms (i.e., subphenotypes such as arthritis, alopecia, fatigue, photosensitivity, Raynaud's phenomenon as well as non-specific autoantibodies, e.g., antinuclear antibodies, rheumatoid factor, anti-Ro antibodies), physiopathological mechanisms (e.g., type I interferon activation, reduced B and T cell regulatory function), and genetic factors at both the MHC and non-MHC loci, has been called the autoimmune tautology and indicates that they have several common mechanisms [1]. One of the strongest arguments supporting the autoimmune tautology is polyautoimmunity, defined as the presence of more than one AD in a single patient [2,3]. When three or more ADs coexist, this extreme phenotype is called multiple autoimmune syndrome (MAS) [4]. Polyautoimmunity has been described in most of the ADs including systemic lupus erythematosus (41%), type 1 diabetes mellitus (35%), Sjögren's syndrome (33%), primary biliary cirrhosis (32%), antiphospholipid syndrome (28%), vitiligo (27%), systemic sclerosis (26%), autoimmune thyroid diseases (15%), multiple sclerosis (15%), rheumatoid arthritis (15%), myasthenia gravis (13%), and alopecia areata (10%). The main factors associated with polyautoimmunity are familial autoimmunity (i.e., the presence of diverse ADs in a nuclear family) and Amerindian ancestry. Based on polyautoimmunity and depending on severity, ADs may be categorized as major and minor diseases. In this sense, how polyautoimmunity affects major ADs has not fully evaluated.
- ÍtemSolo MetadatosTHU0152 Polyautoimmunity and familial autoimmunity in rheumatoid arthritis(2015-06) Anaya, Juan-Manuel; Molano González, Nicolás; Rodríguez Jiménez, Mónica María del Pilar; Amaya-Amaya, J.; Acosta Ampudia, Yeny Yasbleidy; Reyes, B.; Mantilla, R.D.; Rojas-Villarraga, A.Background Polyautoimmunity (PolyA) is defined as the presence of more than one autoimmune disease (AD) in a single patient. When three or more ADs coexist, this extreme phenotype is called multiple autoimmune syndrome (MAS). The study of the same AD in nuclear families, also referred to as familial AD, has been extensively evaluated. However, the study of familial autoimmunity [(FAI) i.e., diverse ADs in a nuclear family] has been overlooked.
- ÍtemSolo MetadatosTHU0292 Comparison of the aecg Sjogren’s syndrome classification Cciteria to the newly proposed ACR criteria in a large, carefully characterized sicca cohort.(2013-06) Rasmussen, A.; Ice, J.; Li, H.; Grundahl, K.; Kelly, J.; Radfar, L.; Stone, D.; Hefner, K.; Anaya, Juan-Manuel; Rohrer, M.; Houston, G.; Lewis, D.; Chodosh, J.; Harley, J.; Maier-Moore, J.; Montgomery, C.; Rhodus, N.; Farris, D.; Segal, B.; Lessard, C.; Scofield, R. H.; Sivils, K.Background Sjögren’s syndrome (SS) is a complex disorder that is classically defined by autoimmune processes that result in exocrine gland dysfunction. There is no single clinical diagnostic test for SS, and for research purposes, multiple classification criteria have been proposed over the past decades; efforts to resolve discrepancies and weaknesses between the systems are ongoing. The most widely used criteria are the 2002 American-European Consensus Group (AECG) criteria; recently (2012), a new classification system has been proposed with provisional endorsement of the American College of Rheumatology (ACR).