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dc.contributorAnaya, Juan Manuel
dc.contributorMonsalve, Diana M.
dc.contributorPacheco, Yovana
dc.contributorRamirez-Santana, Carolina
dc.contributorRodríguez-Jimenez, Monica
dc.contributorRodríguez, Yhojan
dc.contributorMantilla, Ruben Dario
dc.contributor.advisorAcosta-Ampudia, Yeny 
dc.contributor.advisorMolano-González, Nicolas 
dc.creatorRojas Quintana, Manuel Eduardo 
dc.date.accessioned2019-06-12T13:35:10Z
dc.date.available2019-06-12T13:35:10Z
dc.date.created2019-05-30
dc.date.issued2019
dc.identifier.urihttp://repository.urosario.edu.co/handle/10336/19850
dc.description.abstractBACKGROUND: Resilience is considered the capability to positively respond to adverse events. Since this capacity in considered a “continuum” process, long-term stressors and psychosocial factors are thought to be crucial for resilience development, especially in those patients with chronic inflammatory systemic diseases. However, the role of clinical, biological and socioeconomic characteristics in autoimmune rheumatic diseases (ARDs) is still unknown. OBJECTIVE To evaluate the association between resilience and socioeconomic, biological and clinical factors in four autoimmune rheumatic diseases (ARDs) namely: systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), Sjögren’s syndrome (SS) and systemic sclerosis (SSc). METHODS: A cross-sectional study in 188 women with SLE (n= 70), RA (n= 51), SS (n= 32), and SSc (n= 35) was done. Resilience was evaluated by the “Brief Resilience Scale”, whereas independent factors including age, age at onset, duration of disease, socioeconomic status, excersice, severity of symptoms and polyautoimmunity (PolyA) were evaluated by surveys and chart reviews. A panel of 15 serum cytokines and 14 autoantibodies were evaluated simultaneously. Bivariate, classification and regression trees (CART), and multiple linear regressions were used to analyze data. RESULTS: CART analysis showed that patients younger than 48 years with SLE, RA, and SSc who had low socioeconomic status showed the lowest resilience scores, whereas those patients between 48 and 66 years exhibited the highest resilience levels despite socioeconomic status. Interestingly, regular physical activity was associated with highest resilience in SSc. In addition, Interleukin-6 (IL-6) was associated low resilience scores (β= -0.581120, p=0.02) and with severity of symptoms (β=1.8395, p=0.04) in SSc. Neither PolyA nor severity of symptoms influenced resilience in the four ARDs studied. Cytokine levels did not significantly differ between groups based on regular physical activity. CONCLUSIONS: Resilience is a continuum trait associated to socioeconomic status and age. In addition, IL-6 and exercise are key factors for resilience in SSc. These results highlight the relevance of biological and socioeconomic factors in the development of resilience in autoimmunity.
dc.description.sponsorshipCentro de Estudio de Enfermedades Autoinmunes (CREA)
dc.description.sponsorshipUniversidad del Rosario (ABN011)
dc.description.sponsorshipColciencias (Grant No 122254531722/Grant No0425-2013)
dc.format.mimetypeapplication/pdf
dc.language.isospa
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.subjectResilience
dc.subjectRheumatoid arthritis
dc.subjectSystemic lupus erythematosus
dc.subjectSystemic sclerosis
dc.subjectSjögren’s síndrome
dc.subject.ddcEnfermedades 
dc.subject.lembArtritis reumatoide
dc.subject.lembLupus eritematoso sistémico
dc.subject.lembEsclerodermia Sistémica
dc.subject.lembSíndrome de Sjögren
dc.titleThe role of clinical, biological, and socioeconomic factors on the development of resilience in women with autorimmune rheumatic diseases : a cross-sectional study
dc.typemasterThesis
dc.publisherUniversidad del Rosario
dc.creator.degreeMagíster en epidemiología
dc.publisher.programMaestría en Epidemiología
dc.publisher.departmentMaestría en Actividad Física y Salud
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaTesis de maestría
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/acceptedVersion
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