HIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier : A densely sampled transmission dynamics analysis from 1986 to 2012
Date
2018Author
Pineda-Peña, Andrea-ClemenciaTheys, Kristof
Stylianou, Dora C.
Demetriades, Ioannis
Puchhammer, Elisabeth
Vandamme, Anne-Mieke
Aleksiev, Ivailo
Zidovec Lepej, Snjezana
Linka, Marek
Fonage, Jannik
Liitsola, Kirsi
Kaiser, Rolf
Hamouda, Osamah
Paraskevis, Dimitrios
Coughlan, Suzie
Grossman, Zehava
Mor, Orna
Zazzi, Maurizio
Griskevicius, Algirdas
Lipnickiene, Vilnele
Devaux, Carole
Boucher, Charles
Hofstra, Marije
Wensing, Annemarie
Bakken-Kran, Anne-Marte
Horban, Andrzej
Camacho, Ricardo
Paraschiv, Simona
Otelea, Dan
Stanojevic, Maja
Stanekova, Danika
Poljak, Mario
Garcia, Federico
Paredes, Roger
Albert, Jan
Abecasis, Ana
Kostrikis, Leondios G.
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Summary
Since HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings. © 2018 The Author(s).
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