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dc.creatorPineda-Peña, Andrea-Clemencia 
dc.creatorTheys, Kristof 
dc.creatorStylianou, Dora C. 
dc.creatorDemetriades, Ioannis 
dc.creatorPuchhammer, Elisabeth 
dc.creatorVandamme, Anne-Mieke 
dc.creatorAleksiev, Ivailo 
dc.creatorZidovec Lepej, Snjezana 
dc.creatorLinka, Marek 
dc.creatorFonage, Jannik 
dc.creatorLiitsola, Kirsi 
dc.creatorKaiser, Rolf 
dc.creatorHamouda, Osamah 
dc.creatorParaskevis, Dimitrios 
dc.creatorCoughlan, Suzie 
dc.creatorGrossman, Zehava 
dc.creatorMor, Orna 
dc.creatorZazzi, Maurizio 
dc.creatorGriskevicius, Algirdas 
dc.creatorLipnickiene, Vilnele 
dc.creatorDevaux, Carole 
dc.creatorBoucher, Charles 
dc.creatorHofstra, Marije 
dc.creatorWensing, Annemarie 
dc.creatorBakken-Kran, Anne-Marte 
dc.creatorHorban, Andrzej 
dc.creatorCamacho, Ricardo 
dc.creatorParaschiv, Simona 
dc.creatorOtelea, Dan 
dc.creatorStanojevic, Maja 
dc.creatorStanekova, Danika 
dc.creatorPoljak, Mario 
dc.creatorGarcia, Federico 
dc.creatorParedes, Roger 
dc.creatorAlbert, Jan 
dc.creatorAbecasis, Ana 
dc.creatorKostrikis, Leondios G.
dc.descriptionSince HIV-1 treatment is increasingly considered an effective preventionstrategy, it is important to study local HIV-1 epidemics to formulate tailored preventionpolicies. The prevalence of HIV-1 in Cyprus was historically low until 2005. To investigatethe shift in epidemiological trends, we studied the transmission dynamics of HIV-1 in Cyprususing a densely sampled Cypriot HIV-1 transmission cohort that included 85 percent ofHIV-1-infected individuals linked to clinical care between 1986 and 2012 based on detailedclinical, epidemiological, behavioral and HIV-1 genetic information. Subtyping andtransmission cluster reconstruction were performed using maximum likelihood and Bayesianmethods, and the transmission chain network was linked to the clinical, epidemiological andbehavioral data. The results reveal that for the main HIV-1 subtype A1 and B sub-epidemics,young and drug-naïve HIV-1-infected individuals in Cyprus are driving the dynamics of thelocal HIV-1 epidemic. The results of this study provide a better understanding of thedynamics of the HIV-1 infection in Cyprus, which may impact the development of preventionstrategies. Furthermore, this methodology for analyzing densely sampled transmissiondynamics is applicable to other geographic regions to implement effective HIV-1 preventionstrategies in local settings. © 2018 The Author(s).
dc.relation.ispartofScientific Reports, ISSN:2045-2322, Vol. 8 (2018)
dc.subjectInfection Cyprus
dc.subjectOfhivinfected Individuals
dc.subject.lembSíndromes de inmunodeficiencia
dc.titleHIV-1 Infection in Cyprus, the Eastern Mediterranean European Frontier : A densely sampled transmission dynamics analysis from 1986 to 2012
dc.rights.accesoAbierto (Texto Completo)
dc.source.bibliographicCitation(2016) Joint United Nations Programme on HIV/AIDS, , United Nations Programme on HIV/AIDS-UNAIDS-. Fact Sheet 2017: Global Statistics 2016, Geneva, Switzerland
dc.creator.googlePineda-Peña, A.-C.
dc.creator.googleTheys, K.
dc.creator.googleStylianou, D.C.
dc.creator.googleDemetriades, I.
dc.creator.googlePuchhammer, E.
dc.creator.googleVandamme, A.-M.
dc.creator.googleAleksiev, I.
dc.creator.googleLepej, S.Z.
dc.creator.googleLinka, M.
dc.creator.googleFonager, J.
dc.creator.googleLiitsola, K.
dc.creator.googleKaiser, R.
dc.creator.googleHamouda, O.
dc.creator.googleParaskevis, D.
dc.creator.googleCoughlan, S.
dc.creator.googleGrossman, Z.
dc.creator.googleMor, O.
dc.creator.googleZazzi, M.
dc.creator.googleGriskevicius, A.
dc.creator.googleLipnickiene, V.
dc.creator.googleDevaux, C.
dc.creator.googleBoucher, C.
dc.creator.googleHofstra, M.
dc.creator.googleWensing, A.
dc.creator.googleBakken-Kran, A.-M.
dc.creator.googleHorban, A.
dc.creator.googleCamacho, R.
dc.creator.googleParaschiv, S.
dc.creator.googleOtelea, D.
dc.creator.googleStanojevic, M.
dc.creator.googleStanekova, D.
dc.creator.googlePoljak, M.
dc.creator.googleGarcia, F.
dc.creator.googleParedes, R.
dc.creator.googleAlbert, J.
dc.creator.googleAbecasis, A.B.
dc.creator.googleKostrikis, L.G.

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