The nature and nurture of common autoimmunity
Autoimmune diseases are a heterogeneous group of disorders where multiple alterations in the immune system result in a spectrum of syndromes that either target specific organs or affect the body systematically. Although their heterogeneity is due to a collection of diverse conditions based on epidemiology, pathology, or diagnostic criteria, the underlying immunogenetic mechanism might be similar. Herein the nature and nurture of autoimmune diseases considered as a trait are reviewed, and a discussion is given on their multifactorial characteristics. © 2007 New York Academy of Sciences.
Autoimmune disease ; immunological ; Autoimmunity ; Conference paper ; Genetic linkage ; Heredity ; Human ; Immune system ; Immunogenetics ; Immunopathogenesis ; Phenotype ; Animal ; Article ; Autoimmune disease ; Autoimmunity ; Biological model ; Disease predisposition ; Genetics ; Immunology ; Pathology ; Animals ; Autoimmune diseases ; Autoimmunity ; Disease susceptibility ; Humans ; Models ; Aggregation ; Autoimmune disease ; Inheritance patterns ; Linkage ; Segregation ;
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