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High hepatitis E virus seroprevalence in forestry workers and in wild boars in France

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Carpentier, Audrey
Chaussade, Hélène
Rigaud, Emma
Rodriguez, Josefa
Berthault, Camille
Boué, Franck
Tognon, Mauro
Touzé, Antoine
Garcia-Bonnet, Nathalie
Choutet, Patrick




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Hepatitis E virus (HEV) is a fecally and orally transmitted human pathogen of worldwide distribution. In industrial countries, HEV is observed in an increasing number of autochthonous cases and is considered to be an emerging pathogen. A growing body of evidence suggests that HEV is a zoonotic disease, and pig handlers and pig veterinarians have been reported to be high-risk groups for HEV infection. The aims of the present study were to establish the prevalence of anti-HEV in wild boars in France and to identify whether forestry workers are at a higher risk of HEV infection. Three different anti-HEV tests were used to compare their effectiveness in detecting anti-HEV in the general population. The most sensitive test was then used to investigate HEV seroprevalence in 593 forestry workers and 421 wild boars. Anti-HEV was detected in 31% of the forestry workers and 14% of the wild boars. Detection of anti-HEV in humans was correlated with age, geographical location, and occupational activity and in wild boars was correlated with geographical location. HEV infection is frequent in woodcutters in France, and it varies geographically. Further studies are needed to confirm these findings and to elucidate the transmission route and the exact virus reservoirs. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
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Capsid protein , Hepatitis e antibody , Immunoglobulin g , Protein orf2 , Protein orf3 , Unclassified drug , Virus rna , Adult , Age distribution , Article , Blood sampling , Child , Comparative effectiveness , Controlled study , Correlation analysis , Enzyme linked immunosorbent assay , Forest worker , France , Geographic distribution , Hepatitis e , Hepatitis e virus , Hepatitis e virus immunoglobulin g test , High risk population , Human , Human experiment , In house enzyme linked immunosorbent assay , Infection risk , Nonhuman , Normal human , Occupational exposure , Preschool child , Priority journal , Risk assessment , Sandwich enzyme linked immunosorbent assay , School child , Seroprevalence , Virus detection , Virus transmission , Wild boar , Adult , Age factors , Animals , Female , Forestry , France , Geography , Hepatitis antibodies , Hepatitis e , Hepatitis e virus , Humans , Male , Middle aged , Occupational exposure , Risk factors , Seroepidemiologic studies , Sus scrofa , Young adult
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