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Novel taxa of thermally dimorphic systemic pathogens in the Ajellomycetaceae (Onygenales)
Título de la revista
Autores
Dukik, Karolina
Muñoz, Jose F.
Jiang, Yanping
Feng, Peiying
Sigler, Lynne
Stielow, J. Benjamin
Freeke, Joanna
Jamalian, Azadeh
van den Ende, Bert Gerrits
McEwen, Juan G.
Fecha
2017
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Blackwell Publishing Ltd
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Resumen
Abstract
Recent discoveries of novel systemic fungal pathogens with thermally dimorphic yeast-like phases have challenged the current taxonomy of the Ajellomycetaceae, a family currently comprising the genera Blastomyces, Emmonsia, Emmonsiellopsis, Helicocarpus, Histoplasma, Lacazia and Paracoccidioides. Our morphological, phylogenetic and phylogenomic analyses demonstrated species relationships and their specific phenotypes, clarified generic boundaries and provided the first annotated genome assemblies to support the description of two new species. A new genus, Emergomyces, accommodates Emmonsia pasteuriana as type species, and the new species Emergomyces africanus, the aetiological agent of case series of disseminated infections in South Africa. Both species produce small yeast cells that bud at a narrow base at 37°C and lack adiaspores, classically associated with the genus Emmonsia. Another novel dimorphic pathogen, producing broad-based budding cells at 37°C and occurring outside North America, proved to belong to the genus Blastomyces, and is described as Blastomyces percursus. © 2017 Blackwell Verlag GmbH
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Keywords
60S ribosomal protein , Fungal , Elongation factor 3 , Fungal DNA , Fungal protein , Genomic DNA , Unclassified drug , Ajellomyces dermatitidis , Ajellomycetaceae , Article , Blastomyces , Blastomyces gilchristii , Blastomyces percursus , Cell budding , Comparative study , Controlled study , DNA extraction , Emergomyces africanus , Emergomyces orientalis , Emergomyces pasteurianus , Emmonsia , Emmonsia crescens , Emmonsia parva , Emmonsia pasteuriana , Fungal genome , Fungal strain , Molecular genetics , Morphological trait , New species , Nonhuman , North America , Nucleotide sequence , Onygenales , Phylogenomics , Phylogeny , Priority journal , Sequence alignment , South Africa , Whole genome sequencing , Blastomyces , Chrysosporium , Classification , DNA sequence , Fungal genome , Fungus spore , Genetics , Histoplasma , Human , Microbiology , Microscopy , Mycelium , Mycoses , Onygenales , Pathogenicity , Phenotype , Ultrastructure , Blastomyces , Chrysosporium , Genome , Histoplasma , Humans , Microscopy , Mycelium , Mycoses , North America , Onygenales , Phenotype , Phylogeny , Sequence Analysis , South Africa , Spores , Ajellomycetaceae , Blastomyces , Emergomyces , Emmonsia , Genomics , Phylogeny
