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Exposure to pesticide mixtures and DNA damage among rice field workers
Título de la revista
Autores
Varona Uribe, Marcela Eugenia
Torres-Rey, Carlos H
Díaz-Criollo, Sonia
Palma-Parra, Ruth Marien
Narváez, Diana María
Carmona, Sandra Patricia
Briceño Ayala, Leonardo
Idrovo, Alvaro J
Fecha
2016
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Taylor and Francis Inc.
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Abstract
This study describes the use of pesticides mixtures and their potential association with comet assay results in 223 rice field workers in Colombia. Thirty-one pesticides were quantified in blood, serum, and urine (15 organochlorines, 10 organophosphorus, 5 carbamates, and ethylenethiourea), and the comet assay was performed. Twenty-four (77.42%) pesticides were present in the workers. The use of the maximum-likelihood factor analysis identified 8 different mixtures. Afterwards, robust regressions were used to explore associations between the factors identified and the comet assay. Two groups of mixtures-?-benzene hexachloride (?-BHC), hexachlorobenzene (HCB), and ?-BHC (?: 1.21, 95% confidence interval [CI]: 0.33-2.10) and pirimiphos-methyl, malathion, bromophos-methyl, and bromophos-ethyl (?: 11.97, 95% CI: 2.34-21.60)-were associated with a higher percentage of DNA damage and comet tail length, respectively. The findings suggest that exposure to pesticides varies greatly among rice field workers. © 2016 Taylor and Francis.
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Keywords
2 imidazolidinethione , Carbamic acid derivative , chlorinated , Chlorinated hydrocarbon , Organophosphorus compound , Pesticide , Adolescent , Adult , Adverse effects , Aged , Agriculture , Analysis , Blood , Colombia , Comet assay , Cross-sectional study , Dna damage , Drug effects , Female , Human , Male , Middle aged , Occupational exposure , Oryza , Very elderly , Young adult , Adolescent , Adult , Aged , Aged, 80 and over , Agriculture , Carbamates , Colombia , Comet assay , Cross-sectional studies , Dna damage , Ethylenethiourea , Female , Humans , Hydrocarbons , Male , Middle aged , Occupational exposure , Organophosphorus compounds , Oryza , Pesticides , Young adult , Agriculture , Chemical mixtures , Colombia , Genotoxicity , Pesticides
