Ítem
Solo Metadatos
HPV antibody levels and clinical efficacy following administration of a prophylactic quadrivalent HPV vaccine
Título de la revista
Autores
Joura, Elmar A.
Kjaer, Susanne K.
Wheeler, Cosette M.
Sigurdsson, Kristján
Iversen, Ole-Erik
Hernandez-Avila, Mauricio
Perez, Gonzalo
Brown, Darron R.
Koutsky, Laura A.
Tay, Eng Hseon
Resumen
Abstract
The efficacy of the quadrivalent Human Papillomavirus (HPV) vaccine is thought to be mediated by humoral immunity. We evaluated the correlation between quadrivalent HPV vaccine-induced serum anti-HPV responses and efficacy. 17,622 women were vaccinated at day 1, and months 2 and 6. At day 1 and at 6-12 months intervals for up to 48 months, subjects underwent Papanicolaou and genital HPV testing. No immune correlate of protection could be found due to low number of cases. Although 40% of vaccine subjects were anti-HPV 18 seronegative at end-of-study, efficacy against HPV 18-related disease remained high (98.4%; 95% CI: 90.5-100.0) despite high attack rates in the placebo group. These results suggest vaccine-induced protection via immune memory, or lower than detectable HPV 18 antibody titers. © 2008 Elsevier Ltd. All rights reserved.
Palabras clave
Keywords
Placebo , Silgard , Unclassified drug , Virus antibody , Wart virus vaccine , Adolescent , Adult , Antibody production , Antibody response , Article , Cancer immunization , Cancer prevention , Clinical trial , Controlled clinical trial , Controlled study , Double blind procedure , Drug efficacy , Female , Human , Infection prevention , Major clinical study , Phase 3 clinical trial , Priority journal , Randomized controlled trial , Uterine cervix carcinoma in situ , Wart virus , Adolescent , Antibodies , Condylomata acuminata , Female , Follow-up studies , Human papillomavirus 11 , Human papillomavirus 16 , Human papillomavirus 18 , Human papillomavirus 6 , Humans , Immunization schedule , Papillomavirus infections , Papillomavirus vaccines , Reverse transcriptase polymerase chain reaction , Vagina , Vaginal smears , Vulva , Young adult , Human papillomavirus , Humoral immunity , Immune memory
