Show simple item record

dc.creatorShea, Stephanie 
dc.creatorMuñoz, Marina 
dc.creatorWard, Stephen C. 
dc.creatorBeasley, Mary B. 
dc.creatorGitman, Melissa R 
dc.creatorNowak, Michael D 
dc.creatorHouldsworth, Jane 
dc.creatorSordillo, Emilia Mia 
dc.creatorRamírez, Juan David 
dc.creatorMondolfi, Alberto E. Paniz 
dc.date.accessioned2020-05-26T00:02:21Z
dc.date.available2020-05-26T00:02:21Z
dc.date.created2020
dc.identifier.issn19994915
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/23476
dc.description.abstract"Background: Human papillomaviruses (HPVs) have been linked to a variety of human cancers. As the landscape of HPV-related neoplasia continues to expand, uncommon and rare HPV genotypes have also started to emerge. Host-virus interplay is recognized as a key driver in HPV carcinogenesis, with host immune status, virus genetic variants and coinfection highly influencing the dynamics of malignant transformation. Immunosuppression and tissue tropism are also known to influence HPV pathogenesis. Methods: Herein, we present a case of a patient who, in the setting of HIV positivity, developed anal squamous cell carcinoma associated with HPV69 and later developed squamous cell carcinoma in the lungs, clinically presumed to be metastatic disease, associated with HPV73. Consensus PCR screening for HPV was performed by real-time PCR amplification of the L1 gene region, amplification of the E6 regions with High-Resolution Melting Curve Analysis followed by Sanger sequencing confirmation and phylogenetic analysis. Results: Sanger sequencing of the consensus PCR amplification product determined that the anal tissue sample was positive for HPV 69, and the lung tissue sample was positive for HPV 73. Conclusions: This case underscores the importance of recognizing the emerging role of these rare ""possibly carcinogenic"" HPV types in human carcinogenesis. © 2020 by the authors. Licensee MDPI, Basel, Switzerland."
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofViruses, ISSN:19994915, Vol.12, No.3 (2020)
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85082515888&doi=10.3390%2fv12030349&partnerID=40&md5=5c61f73551dc58d30ff5be48051798ef
dc.sourceinstname:Universidad del Rosario
dc.sourcereponame:Repositorio Institucional EdocUR
dc.titleHuman papillomavirus (HPV69/HPV73) coinfection associated with simultaneous squamous cell carcinoma of the anus and presumed lung metastasis
dc.typearticle
dc.publisherMDPI AG
dc.subject.keywordCase report
dc.subject.keywordCarcinogenesis
dc.subject.keywordCoinfection
dc.subject.keywordHpv69
dc.subject.keywordHpv73
dc.subject.keywordHuman papillomaviruses
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.3390/v12030349
dc.relation.citationIssueNo. 3
dc.relation.citationTitleViruses
dc.relation.citationVolumeVol. 12


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record