Validation of an enzyme-linked immunosorbent assay that detects Histoplasma capsulatum antigenuria in colombian patients with AIDS for diagnosis and follow-up during therapy
Abstract
"We validated an antigen capture enzyme-linked immunosorbent assay (ELISA) in Colombian persons with AIDS and proven histoplasmosis and evaluated the correlation between antigenuria and clinical improvement during follow-up. The sensitivity of the Histoplasma capsulatum ELISA was 86%, and the overall specificity was 94%. The antigen test successfully monitored the response to therapy. Copyright © 2014, American Society for Microbiology. All Rights Reserved."
Keyword
Amphotericin B deoxycholate ; Fungal ; Fungus antigen ; Histoplasma capsulatum antigen ; Itraconazole ; Unclassified drug ; Fungus antigen ; Acquired immune deficiency syndrome ; Antigen detection ; Article ; Colombia ; Enzyme linked immunosorbent assay ; Follow up ; Histoplasma capsulatum ; Histoplasmosis ; Human ; Major clinical study ; Nonhuman ; Priority journal ; Sensitivity and specificity ; Treatment response ; Urinalysis ; Validation process ; AIDS-Related Opportunistic Infections ; Cohort analysis ; Diagnostic procedure ; Drug monitoring ; Enzyme linked immunosorbent assay ; Histoplasma ; Histoplasmosis ; Immunology ; Procedures ; Prospective study ; Urine ; Validation study ; AIDS-Related Opportunistic Infections ; Antigens ; Clinical Laboratory Techniques ; Cohort Studies ; Colombia ; Drug Monitoring ; Enzyme-Linked Immunosorbent Assay ; Histoplasma ; Histoplasmosis ; Humans ; Prospective Studies ; Sensitivity and Specificity ;
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