Paracoccidioidomycosis: Latin America's own fungal disorder
"Paracoccidioidomycosis (PCM) is a systemic, endemic fungal disorder restricted to Latin America (Mexico to Argentina); Brazil accounts for the largest number of cases. Imported cases diagnosed in North America, Europe and Asia represent patients who had previously lived in recognized endemic areas. Paracoccidioides brasiliensis, the etiologic agent, is a thermally dimorphic fungus that in patients and cultures at 37 C adopts a yeast form while at lower temperatures it behaves as a mold that bears the infectious conidia. PCM has a peculiar gender distribution with preference for adult males at a ratio of ?11 to 1. PCM afflicts predominantly adult males engaged in agriculture. It is mostly a chronic disease with acute/subacute cases accounting for less than 15 % of all reports. Specific diagnosis is established late and although available therapy is usually successful in controlling the fungal infection, patients who survive usually develop residual fibrotic lesions that heavily impair their quality of life. © 2012 Springer Science+Business Media New York."
Amphotericin B ; Amphotericin B deoxycholate ; Amphotericin B lipid complex ; Antifungal agent ; Corticosteroid ; Cotrimoxazole ; Fluconazole ; Fungus antigen ; Itraconazole ; Ketoconazole ; Pyrrole derivative ; Ribosome RNA ; Sulfonamide ; Voriconazole ; Agriculture ; Alcoholism ; Antigen recognition ; Article ; Brazil ; Cause of death ; Clinical examination ; Clinical feature ; Complement fixation test ; Conidium ; Diagnostic test ; Differential diagnosis ; Disease course ; Dot hybridization ; Drug efficacy ; Drug safety ; Drug treatment failure ; Environmental temperature ; Enzyme linked immunosorbent assay ; Fungal gene ; Fungus culture ; Fungus identification ; Histopathology ; Human ; Immunodiffusion ; Incidence ; Loop mediated isothermal amplification ; Lower respiratory tract infection ; Lung fibrosis ; Molecular diagnosis ; Nonhuman ; Nutrition ; Occupational exposure ; Paracoccidioides brasiliensis ; Pneumonia ; Quality of life ; Race ; Real time polymerase chain reaction ; Recurrent infection ; RNA gene ; Sensitivity and specificity ; Serodiagnosis ; Sex difference ; Smoking ; South American blastomycosis ; Survival ; Unspecified side effect ; Western blotting ; Acute/subacute paracoccidioidomycosis ; Chronic ; Endemic areas ; Laboratory diagnosis ; Latency ; Management ; Paracoccidioides brasiliensis ; Paracoccidioidomycosis ; South American Blastomycosis ;
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