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dc.creatorChavarro Portillo, Bibiana 
dc.creatorMoreno, Jaime Enrique 
dc.creatorYomayusa, Nancy 
dc.creatorAlvarez, Carlos Arturo 
dc.creatorCastro Cardozo, Betsy Esperanza 
dc.creatorEscobar Pérez, Javier Antonio 
dc.creatorDíaz, Paula Lucia 
dc.creatorIbañez, Milciades 
dc.creatorMendez-Alvarez, Sebastián 
dc.creatorLeal, Aura Lucia 
dc.creatorVanegas Gómez, Natasha 
dc.date.accessioned2020-08-06T16:20:29Z
dc.date.available2020-08-06T16:20:29Z
dc.date.created2013
dc.identifier.issnISSN: 1201-9712
dc.identifier.issnEISSN: 1878-3511
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/26027
dc.description.abstractObjective: To determine the molecular epidemiology and presence of virulence genes in communityacquired (CA) and hospital-acquired (HA) methicillin-resistant Staphylococcus aureus (MRSA) isolates and their relationship to clinical outcomes. Methods: An observational and prospective study of infections caused by MRSA was conducted between June 2006 and December 2007 across seven hospitals in three Colombian cities. MRSA isolates were analyzed for SCCmec. Also, pulsed-field gel electrophoresis and multilocus sequence typing were performed and 25 virulence genes were identified. Results: Two hundred and seventy isolates were collected from 262 adult hospital patients with MRSA infections. Overall, 68% of the isolates were classified as HA-MRSA and 32% as CA-MRSA. We identified differences in the patterns of virulence genes: 85% of HA-MRSA isolates possessed the enterotoxin gene cluster (egc), whereas 92% of CA-MRSA isolates possessed the lukF-PV/lukS-PV genes. Multivariate analysis showed an increased risk of mortality for seg (p = 0.001, odds ratio 4.73) and a protective effect for eta (p = 0.018, odds ratio 0.33). Conclusions: Our study confirms that three clones of MRSA predominantly circulate in Colombia: a Chilean clone, a pediatric clone that causes HA-MRSA infections, and a USA300-related clone (SCCmec IVc) in CA-MRSA infections, which differ in the content of clinically important virulence genes. This study confirms that PVL is not a determinant of severity or mortality in CA-MRSA infections. 2013 International Society for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
dc.format.mimetypeapplication/pdf
dc.language.isoeng
dc.relation.ispartofInternational Journal of Infectious Diseases, ISSN: 1201-9712;EISSN: 1878-3511, Vol.17, No.9 (September, 2013); pp.e744-e749
dc.relation.urihttps://www.ijidonline.com/action/showPdf?pii=S1201-9712%2813%2900122-7
dc.sourceInternational Journal of Infectious Diseases
dc.titleMolecular epidemiology and characterization of virulence genes of community-acquired and hospital-acquired methicillin-resistant staphylococcus aureus isolates in Colombia
dc.typearticle
dc.publisherInternational Society for Infectious Diseases
dc.publisherElsevier
dc.subject.keywordStaphylococcus aureus
dc.subject.keywordCA-MRSA
dc.subject.keywordAntibiotic resistance
dc.subject.keywordEnterotoxins
dc.subject.keywordUSA300
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.type.spaArtículo
dc.rights.accesoAbierto (Texto Completo)
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.identifier.doihttps://doi.org/10.1016/j.ijid.2013.02.029
dc.title.TranslatedTitleEpidemiología molecular y caracterización de genes de virulencia de aislados de estafilococo aureus resistentes a la meticilina adquiridos en la comunidad y adquiridos en el hospital en Colombia


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