Ítem
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Temporal variation of trypanosoma cruzi discrete typing units in asymptomatic Chagas disease patients
Título de la revista
Autores
Sánchez, Laura V.
Bautista, Diana C.
Corredor, Andrés F.
Herrera, Victor M.
Martinez, Luz X.
Villar, Juan Carlos
Ramírez, Juan David
Fecha
2013-06-27
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Editor
Institut Pasteur
Elsevier
Elsevier
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Resumen
Abstract
Chagas disease caused by Trypanosoma cruzi is a public health problem in Latin America. This parasite displays a high genetic diversity evidenced in six Discrete Typing Units (DTUs) namely TcI–TcVI. The aim of this study was to observe the temporal variation of the DTUs in asymptomatic patients at three different times (10 days interval). The results showed that intermittence is the rule in the bloodstream of Chagas disease patients. The patients showed different detectable DTUs with short time intervals, which favors the clonal histiotropic model and the multiclonality structure of this parasite.
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Keywords
Discrete typing unit , Multiclonality , Chagas disease , Temporal distributionSL-IR
