Ítem
Acceso Abierto
A Mutation in DAOA Modifies the Age of Onset in PSEN1 E280A Alzheimer's Disease
Título de la revista
Autores
Vélez, Jorge I.
Rivera, Dora
Mastronardi, Claudio A.
Patel, Hardip R.
Tobón, Carlos
Villegas, Andrés
Cai, Yeping
Easteal, Simon
Lopera, Francisco
Arcos-Burgos, Mauricio
Archivos
Fecha
2016-01-05
Directores
ISSN de la revista
Título del volumen
Editor
Hindawi
Buscar en:
Métricas alternativas
Resumen
Abstract
We previously reported age of onset (AOO) modifier genes in the world’s largest pedigree segregating early-onset Alzheimer’s disease (AD), caused by the p.Glu280Ala (E280A) mutation in the PSEN1 gene. Here we report the results of a targeted analysis of functional exonic variants in those AOO modifier genes in sixty individuals with PSEN1 E280A AD who were whole-exome genotyped for ~250,000 variants. Standard quality control, filtering, and annotation for functional variants were applied, and common functional variants located in those previously reported as AOO modifier loci were selected. Multiloci linear mixed-effects models were used to test the association between these variants and AOO. An exonic missense mutation in the G72 (DAOA) gene (rs2391191, P = 1.94 × 10?4, PFDR = 9.34 × 10?3) was found to modify AOO in PSEN1 E280A AD. Nominal associations of missense mutations in the CLUAP1 (rs9790, P = 7.63 × 10?3, PFDR = 0.1832) and EXOC2 (rs17136239, P = 0.0325, PFDR = 0.391) genes were also found. Previous studies have linked polymorphisms in the DAOA gene with the occurrence of neuropsychiatric symptoms such as depression, apathy, aggression, delusions, hallucinations, and psychosis in AD. Our findings strongly suggest that this new conspicuous functional AOO modifier within the G72 (DAOA) gene could be pivotal for understanding the genetic basis of AD
Palabras clave
Keywords
A Mutation , DAOA Modifies , Age of Onset , PSEN1 E280A , Alzheimer’s Disease
