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Therapy for ocular toxoplasmosis
Título de la revista
Autores
de-la-Torre, Alejandra
Stanford, Miles
Curi, Andre
Jaffe, Glenn J.
Gomez-Marin, Jorge E.
Fecha
2011-10-04
Directores
ISSN de la revista
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Editor
International Uveitis Study Group
Uveitis Society of India
Uveitis Society of India
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Resumen
Abstract
Purpose: To review current evidence for the treatment of ocular toxoplasmosis (OT). Design: Narrative review and expert recommendations. Methods: Meta-analysis and selected original articles from the medical literature were reviewed critically. Expert recommendations were analyzed. Results: Numerous observational studies suggest a benefit of short-term antimicrobial therapy for toxoplasmic retinochoroiditis in immunocompetent patients, although its efficacy has not been proven in randomized clinical trials. A randomized clinical trial revealed that intermittent trimethoprim/sulfamethoxazole treatment could decrease the rate of recurrence in high-risk patients. Intravitreal injection of clindamycin and dexamethasone was an acceptable alternative to the classic treatment for OT in a randomized clinical trial. Conclusions: Opinions about therapy differ and controversy remains about its type, efficacy, and length. Intravitreal therapy may be promising for OT. A recent description of the presence of parasitemia in patients with active and inactive ocular toxoplasmosis raises new questions that need to be explored.
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Keywords
Antibiotics , Ocular toxoplasmosis , Recurrences , Steroids , Therapy , Treatment , Uveitis
