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dc.creatorMunoz, Marina 
dc.creatorCamargo, Milena 
dc.creatorSoto De Leon, Sara C 
dc.creatorSánchez, Ricardo 
dc.creatorParra, Diana 
dc.creatorPineda, Andrea C. 
dc.creatorSussmann, Otto 
dc.creatorPerez-Prados, Antonio 
dc.creatorPatarroyo, Manuel E. 
dc.creatorPatarroyo, Manuel A. 
dc.description.abstractInfection, coinfection and type-specific human papillomavirus (HPV) distribution was evaluated in human immunodeficiency virus (HIV)-positive women from paired cervical and urine samples. Paired cervical and urine samples (n = 204) were taken from HIV-positive women for identifying HPV-DNA presence by using polymerase chain reaction (PCR) with three generic primer sets (GP5+/6+, MY09/11 and pU1M/2R). HPV-positive samples were typed for six high-risk HPV (HR-HPV) (HPV-16, -18, -31, -33, -45 and -58) and two low-risk (LR-HPV) (HPV-6/11) types. Agreement between paired sample results and diagnostic performance was evaluated. HPV infection prevalence was 70.6% in cervical and 63.2% in urine samples. HPV-16 was the most prevalent HPV type in both types of sample (66.7% in cervical samples and 62.0% in urine) followed by HPV-31(47.2%) in cervical samples and HPV-58 (35.7%) in urine samples. There was 55.4% coinfection (infection by more than one type of HPV) in cervical samples and 40.2% in urine samples. Abnormal Papanicolau smears were observed in 25.3% of the women, presenting significant association with HPV-DNA being identified in urine samples. There was poor agreement of cervical and urine sample results in generic and type-specific detection of HPV. Urine samples provided the best diagnosis when taking cytological findings as reference. In conclusion including urine samples could be a good strategy for ensuring adherence to screening programs aimed at reducing the impact of cervical cancer, since this sample is easy to obtain and showed good diagnostic performance.
dc.format.mediumRecurso electrónico
dc.relation.ispartofPLOS ONE ISSN: 1932-6203 V. 8 N. 2 Feb 13, 2013
dc.sourcereponame:Repositorio Institucional EdocUR
dc.sourceinstname:Universidad del Rosario
dc.subject.ddcGinecología & otras especialidades médicas 
dc.titleHuman papillomavirus detection from human immunodeficiency virus-infected colombian women's paired urine and cervical samples
dc.audienceComunidad Rosarista
dc.publisherUniversidad del Rosario
dc.subject.keywordPOSITIVE WOMEN
dc.subject.keywordHPV INFECTION
dc.subject.keywordDNA DETECTION
dc.subject.keywordPRIMER SETS
dc.subject.decsVirus del papiloma humano. VPH
dc.subject.decsSíndrome de Inmunodeficiencia Adquirida. SIDA
dc.subject.decsEnfermedades infecciosas
dc.rights.accesoAbierto (Texto completo)
dc.rights.licenciaEL AUTOR, manifiesta que la obra objeto de la presente autorización es original y la realizó sin violar o usurpar derechos de autor de terceros, por lo tanto la obra es de exclusiva autoría y tiene la titularidad sobre la misma.
dc.creator.googleMunoz, Marina
dc.creator.googleCamargo, Milena
dc.creator.googleSoto De Leon, Sara C
dc.creator.googleSanchez, Ricardo
dc.creator.googleParra, Diana
dc.creator.googlePineda, Andrea C.
dc.creator.googleSussmann, Otto
dc.creator.googlePerez-Prados, Antonio
dc.creator.googlePatarroyo, Manuel E.
dc.creator.googlePatarroyo, Manuel A.

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