Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice

Martínez, Paola A.; Yandar, Nubia; Lesmes, Liliana P.; Forero, Martha; Pérez-Leal, Oscar; Patarroyo, Manuel Elkin; Lozano, José Manuel

Ítem

Acceso Abierto

Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice

https://repository.urosario.edu.co/handle/10336/22784
https://doi.org/10.1016/j.peptides.2008.10.022

Autores

Martínez, Paola A.

Yandar, Nubia

Lesmes, Liliana P.

Forero, Martha

Pérez-Leal, Oscar

Patarroyo, Manuel Elkin

Lozano, José Manuel

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Fecha

2009

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Abstract

We have developed monoclonal antibodies directed against the pseudopeptide ?-130, derived from the highly conserved malarial antigen Plasmodium falciparum merozoite surface protein 2 (MSP-2), for obtaining novel molecular tools with potential applications in the control of malaria. Following isotype switching, these antibodies were tested for their ability to suppress blood-stage parasitemia through passive immunization in malaria-infected mice. Some proved totally effective in suppressing a lethal blood-stage challenge infection and others reduced malarial parasitemia. Protection against P. berghei malaria following Ig passive immunization can be associated with specific immunoglobulins induced by a site-directed designed MSP-2 reduced amide pseudopeptide. © 2008 Elsevier Inc. All rights reserved.

Keywords

Immunoglobulin , Immunoglobulin class , Malaria vaccine , Merozoite surface protein 2 , Monoclonal antibody , Monoclonal antibody anti pseudopeptide psi 130 , Pseudopeptide , Unclassified drug , Animal cell , Animal experiment , Animal model , Animal tissue , Article , Controlled study , Drug design , Drug mechanism , Drug synthesis , Female , Mouse , Nonhuman , Parasitemia , Passive immunization , Plasmodium berghei infection , Plasmodium falciparum , Priority journal , Animals , Antibodies, protozoan , Antigens, protozoan , Disease models, animal , Female , Immunization, passive , Malaria , Mice , Mice, inbred balb c , Parasitemia , Plasmodium berghei , Plasmodium falciparum , Protozoan proteins , Recombinant proteins , Murinae , Mus , Plasmodium berghei , Plasmodium falciparum , Anti-malarial vaccine , Ig isotype , In vivo neutralizing activity , Murine malarial infection , Pseudopeptide