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Passive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected mice

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dc.creatorMartínez, Paola A.spa
dc.creatorYandar, Nubiaspa
dc.creatorLesmes, Liliana P.spa
dc.creatorForero, Marthaspa
dc.creatorPérez-Leal, Oscarspa
dc.creatorPatarroyo, Manuel Elkinspa
dc.creatorLozano, José Manuelspa
dc.date.accessioned2020-05-25T23:58:00Z
dc.date.available2020-05-25T23:58:00Z
dc.date.created2009spa
dc.description.abstractWe have developed monoclonal antibodies directed against the pseudopeptide ?-130, derived from the highly conserved malarial antigen Plasmodium falciparum merozoite surface protein 2 (MSP-2), for obtaining novel molecular tools with potential applications in the control of malaria. Following isotype switching, these antibodies were tested for their ability to suppress blood-stage parasitemia through passive immunization in malaria-infected mice. Some proved totally effective in suppressing a lethal blood-stage challenge infection and others reduced malarial parasitemia. Protection against P. berghei malaria following Ig passive immunization can be associated with specific immunoglobulins induced by a site-directed designed MSP-2 reduced amide pseudopeptide. © 2008 Elsevier Inc. All rights reserved.eng
dc.format.mimetypeapplication/pdf
dc.identifier.doihttps://doi.org/10.1016/j.peptides.2008.10.022
dc.identifier.issn1969781
dc.identifier.urihttps://repository.urosario.edu.co/handle/10336/22784
dc.language.isoengspa
dc.relation.citationEndPage342
dc.relation.citationIssueNo. 2
dc.relation.citationStartPage330
dc.relation.citationTitlePeptides
dc.relation.citationVolumeVol. 30
dc.relation.ispartofPeptides, ISSN:1969781, Vol.30, No.2 (2009); pp. 330-342spa
dc.relation.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-58149484910&doi=10.1016%2fj.peptides.2008.10.022&partnerID=40&md5=e5477e7d371aea7c48e5732ae309ed1bspa
dc.rights.accesRightsinfo:eu-repo/semantics/openAccess
dc.rights.accesoAbierto (Texto Completo)spa
dc.source.instnameinstname:Universidad del Rosariospa
dc.source.reponamereponame:Repositorio Institucional EdocURspa
dc.subject.keywordImmunoglobulinspa
dc.subject.keywordImmunoglobulin classspa
dc.subject.keywordMalaria vaccinespa
dc.subject.keywordMerozoite surface protein 2spa
dc.subject.keywordMonoclonal antibodyspa
dc.subject.keywordMonoclonal antibody anti pseudopeptide psi 130spa
dc.subject.keywordPseudopeptidespa
dc.subject.keywordUnclassified drugspa
dc.subject.keywordAnimal cellspa
dc.subject.keywordAnimal experimentspa
dc.subject.keywordAnimal modelspa
dc.subject.keywordAnimal tissuespa
dc.subject.keywordArticlespa
dc.subject.keywordControlled studyspa
dc.subject.keywordDrug designspa
dc.subject.keywordDrug mechanismspa
dc.subject.keywordDrug synthesisspa
dc.subject.keywordFemalespa
dc.subject.keywordMousespa
dc.subject.keywordNonhumanspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordPassive immunizationspa
dc.subject.keywordPlasmodium berghei infectionspa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordPriority journalspa
dc.subject.keywordAnimalsspa
dc.subject.keywordAntibodies, protozoanspa
dc.subject.keywordAntigens, protozoanspa
dc.subject.keywordDisease models, animalspa
dc.subject.keywordFemalespa
dc.subject.keywordImmunization, passivespa
dc.subject.keywordMalariaspa
dc.subject.keywordMicespa
dc.subject.keywordMice, inbred balb cspa
dc.subject.keywordParasitemiaspa
dc.subject.keywordPlasmodium bergheispa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordProtozoan proteinsspa
dc.subject.keywordRecombinant proteinsspa
dc.subject.keywordMurinaespa
dc.subject.keywordMusspa
dc.subject.keywordPlasmodium bergheispa
dc.subject.keywordPlasmodium falciparumspa
dc.subject.keywordAnti-malarial vaccinespa
dc.subject.keywordIg isotypespa
dc.subject.keywordIn vivo neutralizing activityspa
dc.subject.keywordMurine malarial infectionspa
dc.subject.keywordPseudopeptidespa
dc.titlePassive transfer of Plasmodium falciparum MSP-2 pseudopeptide-induced antibodies efficiently controlled parasitemia in Plasmodium berghei-infected micespa
dc.typearticleeng
dc.type.hasVersioninfo:eu-repo/semantics/publishedVersion
dc.type.spaArtículospa
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